Advancing Allogeneic NK Cell Immunotherapy through Microfluidic Gene Delivery.

Chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer treatment, yet challenges such as manufacturing complexity, high costs, and safety concerns have spurred the development of alternatives like CAR-natural killer (NK) cell immunotherapies. CAR-NK cell therapies provide innate cytotoxicity with antigen-independent targeting, reducing safety risks while improving therapeutic efficacy. However, efficient genomic engineering and large-scale production of allogeneic NK cells remain significant obstacles.

Subchronic toxicity evaluation of ethanol extract of Cassia tora L. seeds in rats.

Cassia tora Linn. is an annual or perennial plant of the Fabaceae/Leguminosae family. It is used in traditional medicine for various biological activities including anti-constipation, anti-inflammatory, visual acuity, and hepato-protective activities.

A 90-Day Repeated Oral Dose Toxicity Study of Aqueous Extract in Rats.

(AR), the dried rhizome of (Sam.) Juzep, is a well-known, traditional medicine that is used for the various biological activities including as a diuretic, to lower cholesterol and as an anti-inflammatory agent. The present study was carried out to investigate the potential toxicity of the aqueous extract (ARAE) following 90-day repeated oral administration to Sprague-Dawley rats.

Water Extract of Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA/1 Mice.

The dry rhizome of Solander, known as Rhizoma, is used to treat dementia, stroke, eczema, and indigestion in traditional Chinese medicine, traditional Korean medicine, and traditional Japanese Kampo medicine. Previous studies have reported that Rhizoma extract ameliorated cognitive impairment in A1-42 injected mice. However, the effect of Rhizoma on type II collagen induced arthritis (CIA) has not been elucidated.

Beneficial Effects of Cynaroside on Cisplatin-Induced Kidney Injury and .

Anti-cancer drugs such as cisplatin and doxorubicin are effectively used more than radiotherapy. Cisplatin is a chemotherapeutic drug, used for treatment of various forms of cancer. However, it has side effects such as ototoxicity and nephrotoxicity.

Acute toxicity and cytotoxicity evaluation of aqueous extract and .

(L.) Sw., an herb of the family, has long been used in traditional medicine to strengthen bones, nourish the stomach, and promote the production of bodily fluid.

Neuroprotection by valproic Acid in mouse models of permanent and transient focal cerebral ischemia.

Valproic acid (VPA) is a well-known anti-epileptic and mood stabilizing drug. A growing number of reports demonstrate that VPA is neuroprotective against various insults. Despite intensive efforts to develop new therapeutics for stroke over the past two decades, all treatments have thus far failed to show clinical effect because of treatment-limiting side effects of the drugs.