Sulfonamide-Based Azaheterocyclic Schiff Base Derivatives as Potential Carbonic Anhydrase Inhibitors: Synthesis, Cytotoxicity, and Enzyme Inhibitory Kinetics.

A series of sulfonamide-bearing azaheterocyclic Schiff base derivatives were synthesized as carbonic anhydrase inhibitors. The substituted benzene sulfonyl chlorides were reacted with NH to get aromatic sulfonyl hydrazides . The intermediate hydrazides were treated with substituted aldehydes to afford azaheterocyclic sulfonamide Schiff bases .