Publications by authors named "Muhtadi Alnababteh"
Background: A prior single-center, retrospective cohort study identified baseline lung allograft dysfunction (BLAD) as a risk factor for death in bilateral lung transplant recipients. In this multicenter prospective cohort study, we test the association of BLAD with death in bilateral lung transplant recipients, identify clinical risk factors for BLAD, and assess its association with allograft injury on the molecular level.
Methods: This multicenter, prospective cohort study included 173 bilateral lung transplant recipients that underwent serial pulmonary function testing and plasma collection for donor-derived cell-free DNA at prespecified time points.
Background: Lung transplant recipients are traditionally monitored with pulmonary function testing (PFT) and lung biopsy to detect post-transplant complications and guide treatment. Plasma donor-derived cell free DNA (dd-cfDNA) is a novel molecular approach of assessing allograft injury, including subclinical allograft dysfunction. The aim of this study was to determine if episodes of extreme molecular injury (EMI) in lung transplant recipients increases the risk of chronic lung allograft dysfunction (CLAD) or death.
View Article and Find Full Text PDFPlasma cell-free DNA levels correlate with disease severity in many conditions. Pretransplant cell-free DNA may risk stratify lung transplant candidates for post-transplant complications. To evaluate if pretransplant cell-free DNA levels and tissue sources identify patients at high risk of primary graft dysfunction and other pre- and post-transplant outcomes.
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- Racial and ethnic minority groups have faced greater challenges from COVID-19, prompting a study to analyze how these factors relate to critical clinical outcomes, like the need for ventilation and mortality rates.
- The study analyzed data from 2,931 patients hospitalized with severe COVID-19 from March to July 2020, separating them into non-Hispanic White, non-Hispanic Black, and Hispanic groups, finding significant differences in age and health outcomes among the groups.
- Black and Hispanic patients showed higher odds of requiring mechanical ventilation compared to White patients, but once age was considered, there were no significant differences in death rates between these racial groups.
Article Synopsis
- This study focused on the complications of bleeding and thrombosis in COVID-19 patients on venovenous ECMO support.
- Researchers found that nonsurvivors had significantly higher levels of lactate dehydrogenase (LDH), worse platelet/fibrinogen function, and elevated D-dimer compared to survivors.
- There was also a notable link between inflammatory markers and coagulation issues in nonsurvivors, who experienced higher rates of complications like bleeding, ischemia, acute renal failure, and bloodstream infections.
Background: Critically ill patients with COVID-19 infection on extracorporeal membrane oxygenation (ECMO) face high morbidity and mortality. Palliative care consultation may benefit these patients and their families. Prior to the pandemic, our institution implemented a policy of automatic palliative care consultation for all patients on ECMO due to the high mortality, medical complexity, and psychosocial distress associated with these cases.
View Article and Find Full Text PDFObjectives: To evaluate if a hospitalwide sepsis performance improvement initiative improves compliance with the Centers for Medicare and Medicaid Services-mandated sepsis bundle interventions and patient outcomes.
Study Design: Retrospective analysis comparing 6 months before and 14 months after intervention.
Setting: Tertiary teaching hospital in Washington, DC.
Background: Although many patients with coronavirus disease 2019 (Covid-19) require direct admission to the intensive care unit (ICU), some are sent after admission. Clinicians require an understanding of this phenomenon and various risk stratification approaches for recognizing these subjects.
Methods: We examined all Covid-19 patients sent initially to a ward who subsequently required care in the ICU.
Introduction: The pandemic of the coronavirus disease 2019 (COVID-19) and associated pneumonia represent a clinical and scientific challenge. The role of Extracorporeal Membrane Oxygenation (ECMO) in such a crisis remains unclear.
Methods: We examined COVID-19 patients who were supported for acute respiratory failure by both conventional mechanical ventilation (MV) and ECMO at a tertiary care institution in Washington DC.