Erythrocyte deformability is essential for tissue perfusion, and this study investigates how Thymoquinone affects this property in rats with lower extremity ischemia-reperfusion injury.
Researchers divided Wistar rats into five groups, including a control and various Thymoquinone treatment groups, to examine its effects on erythrocyte deformability and other markers post-injury.
Results showed that Thymoquinone significantly improved erythrocyte deformability and morphology while increasing the activity of endothelial nitric oxide synthase compared to the untreated ischemia-reperfusion group.*