Publications by authors named "Muhanna Kazempour"
Background: Obesity is a prevalent metabolic disorder that significantly contributes to insulin resistance (IR), type 2 diabetes (T2DM), and metabolic syndrome. Sleeve gastrectomy has emerged as an effective surgical intervention for obesity, with potential benefits on metabolic health. This study investigates the impact of sleeve gastrectomy on serum insulin levels, IR (HOMA-IR), inflammatory markers, C-peptide, kidney function, and various biochemical parameters in diabetic and non-diabetic patients.
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- - A 24-year-old Iranian woman with severe Takayasu's arteritis developed multiple sclerosis (MS) during her aggressive treatment, which involved IV methylprednisolone and monthly cyclophosphamide.
- - After two months of treatment, she experienced vision loss, leading to a diagnosis of optic neuritis (ON) linked to her newly diagnosed MS.
- - The case highlights the complexity of distinguishing between CNS vasculitis due to Takayasu's arteritis and coexisting MS, emphasizing the importance of avoiding TNF inhibitors in such cases.
Background: Diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE) is challenging due to nonspecific biomarkers. High serum levels of neurofilament protein light subunit (NFL), high mobility group box 1 (HMGB1), Matrix metalloproteinase-9 (MMP-9) and have been reported in several autoimmune diseases. The aim of this study was to examine whether their plasma levels could serve as a diagnostic or prognostic biomarker for NPSLE.
View Article and Find Full Text PDFIntroduction: Uncontrolled overproduction of inflammatory mediators is predominantly observed in patients with severe COVID-19. The excessive immune response gives rise to multiple organ dysfunction. Implementing extracorporeal therapies may be useful in omitting inflammatory mediators and supporting different organ systems.
View Article and Find Full Text PDFMetronidazole (MTZ) can decrease the levels of several cytokines. This research aimed at the investigation of the anti-inflammatory impact of MTZ in COVID-19. A randomized, single-blind clinical trial for comparing the anti-inflammatory effect of MTZ in two eligible groups of adult patients with lower respiratory tract involvement due to Covid-19 treated with a standard national method with or without MTZ was performed.
View Article and Find Full Text PDFAn investigation into the beneficial effects of high-dose interferon beta 1-a, compared to low-dose interferon beta 1-a in severe COVID-19: The COVIFERON II randomized controlled trial.
Int Immunopharmacol
October 2021
Article Synopsis
- A clinical trial investigated the effectiveness of high-dose versus low-dose interferon-beta 1a (IFN-β 1a) for treating severe COVID-19 in hospitalized patients.
- The trial involved 168 participants randomly assigned to receive either a high-dose or low-dose treatment regimen, combined with the antiviral medication lopinavir/ritonavir.
- Results showed that patients receiving low-dose IFN-β 1a experienced a quicker clinical improvement and similar mortality rates compared to those on high-dose treatment, indicating no benefit from the higher dosage.
The initial manifestation of emphysematous pyelonephritis (EPN) with hiccups is extremely rare. We report a 47-year-old diabetic man with complaint of persistent hiccups as the first manifestation. Class 3B EPN was confirmed based on findings of Contrast-enhanced abdominal multi-slice CT scan.
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