Publications by authors named "Muhammed Sani Sallau"
Article Synopsis
- * A structure-based drug design approach was utilized to create eighteen new inhibitors targeting SmDHODH, with successful binding characteristics and improved efficacy compared to existing treatments.
- * The study highlights the significance of molecular properties in developing effective drugs for schistosomiasis, demonstrating the new compounds' strong inhibition of SmDHODH and promising pharmacokinetic profiles.
Schistosomiasis, also known as bilharzia or snail fever, is a tropical parasitic disease resulting from flatworms of the Schistosoma genus. This often overlooked disease has significant impacts in affected regions, causing enduring morbidity, hindering child development, reducing productivity, and creating economic burdens. Praziquantel (PZQ) is currently the only treatment option for schistosomiasis.
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- Schistosomiasis is a significant neglected tropical disease that causes long-term health issues, particularly affecting child development and economic productivity in affected areas.
- Researchers are focusing on discovering new effective treatments due to challenges like drug resistance, using advanced techniques like quantitative structure-activity relationship (QSAR) studies and molecular simulations on 39 compounds targeting a specific enzyme (SmTGR).
- A leading candidate was identified (compound 40) from this study, leading to the design of 12 new compounds with improved efficacy and stability, indicating their potential as innovative treatments for schistosomiasis.