Publications by authors named "Muhammed Mirac Kelestemur"
Neuropathic pain is associated with diverse etiologies, including sciatica, diabetes, and the use of chemotherapeutic agents. Despite the varied origins, mitochondrial dysfunction, oxidative stress, and inflammatory cytokines are recognized as key contributing factors in both the initiation and maintenance of neuropathic pain. The effects of the mitochondrial-derived peptide humanin on neuropathic pain, however, remain unclear, despite its demonstrated influence on these mechanisms in numerous disease models.
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- The study looks at how chronic treatment with humanin (HN) affects pain-related markers in the dorsal root ganglia (DRG) of diabetic mice.
- HN treatment significantly lowered levels of NMDA, IL-1β, TRPV1, and substance P, which are associated with pain and inflammation.
- It also enhanced the survival of DRG neurons by activating the JAK2/STAT3 pathway, indicating potential therapeutic benefits for diabetes-related pain management.
Article Synopsis
- - Asprosin, a hormone from fat tissue, may help protect nerve cells from damage caused by high glucose levels, which is particularly relevant for people with obesity-related diabetes.
- - The study found that high glucose conditions decrease cell survival and increase cell death in nerve cells, but asprosin treatment improved cell health by activating a specific protein pathway (PKA).
- - Lastly, asprosin also influenced the expression of miRNA-181a, a molecule linked to essential cellular processes, suggesting its potential as a therapeutic target for treating neurological issues associated with diabetes.
Kisspeptin and gonadotropin-inhibitory hormone (GnIH) are among suggested neuroendocrine modulators of reproductive function. Intracellular calcium signaling is a critical component in the regulation of a variety of physiological and pathological processes including neurotransmitter release, and, therefore, can be used as signaling indicator for investigating the involvement of kisspeptin, GnIH, and gonadotropin-releasing hormone (GnRH) release. Hence, this study investigated the effects of kisspeptin and GnIH on calcium signaling using immortalized hypothalamic cells (rHypoE-8) as a model.
View Article and Find Full Text PDFAsprosin, a novel therapeutic candidate for painful neuropathy: an experimental study in mice.
Naunyn Schmiedebergs Arch Pharmacol
March 2022
Recent studies indicate presence of a strong link between adipokines and neuropathic pain. However, the effects of asprosin, a novel adipokine, on neuropathic pain have not been studied in animal models.Mouse models were employed to investigate the antinociceptive effectiveness of asprosin in the treatment of three types of neuropathic pain, with metabolic (streptozocin/STZ), toxic (oxaliplatin/OXA), and traumatic (sciatic nerve ligation/CCI [chronic constriction nerve injury]) etiologies, respectively.
View Article and Find Full Text PDFObjectives: We aimed to investigate the effects of asprosin on diabetes with a focus on serum glucose, irisin, ghrelin, leptin levels and hepatic levels of triglycerides (TG), cholesterol, low-density lipoprotein (LDL).
Methods: Asprosin (10 µg/kg) was administered intraperitoneally four times at 3-day intervals and then blood and hepatic parameters above mentioned were investigated in control and diabetic mice.
Results: The administration of asprosin increased blood glucose level in healthy animals ( = .