Publications by authors named "Muhammed L Sambou"
Objective: To summarise available evidence on time to nursing home admission and death among people with dementia, and to explore prognostic indicators.
Design: Systematic review and meta-analysis.
Data Sources: Medline, Embase, Web of Science, Cochrane, and Google Scholar from inception to 4 July 2024.
What Is Already Known About This Topic?: China is rapidly encountering population aging, yet studies on aging are limited by the traditional aging measure: chronological age, particularly in the field of genomics. Several promising aging measures have been proposed, but they lack comparative evaluation.
What Is Added By This Report?: PhenoAge was identified as a measure of aging that demonstrated greater applicability in contemporary populations.
Background: We examined the factors associated with knowledge of hypertension risk factors and symptoms among Gambian women.
Methods: This cross-section study was based on 11, 865 female participants (aged 15-49 years) of The Gambia Demographic and Health Survey 2019-2020. We performed descriptive statistics, and multivariate-adjusted logistic regression models.
To elucidate the epigenetic consequences of DNA methylation in healthspan termination (HST), considering the current limited understanding. Genetically predicted DNA methylation models were established (n = 2478). These models were applied to genome-wide association study data on HST.
View Article and Find Full Text PDFBackground: Although the association between sleep behavior and morbidity and mortality risk has been reported before, there is still uncertainty whether the observed associations are causal or confounding. Therefore, we investigated the causal relationships between sleep-behavioral traits and terminated healthspan risk using Mendelian randomization (MR).
Methods: We conducted a one-sample MR analysis to evaluate causality between six sleep-behavioral traits (sleep duration, chronotype/morningness, napping, sleeplessness/insomnia, and getting up from bed) and risk of healthspan termination among 388, 909 UK Biobank (UKB) participants.
Study Objectives: To investigate whether sleep traits are associated with the risk of biological aging using a case-control design with Mendelian randomization (MR) analyses.
Methods: We studied 336 559 participants in the UK Biobank cohort, including 157 227 cases of accelerated biological aging and 179 332 controls. PhenoAge, derived from clinical traits, estimated biological ages, and the discrepancies from chronological age were defined as age accelerations (PhenoAgeAccel).
: Job burnout is prevalent among primary care providers (PCPs) in different countries, and the factors that can alleviate burnout in these countries have been explored. However, no study has addressed the prevalence and the correlates of job burnout among Togolese PCPs. Therefore, we aimed to examine the prevalence of burnout and its association with social support and psychological capital among PCPs in Togo.
View Article and Find Full Text PDFTo examine the major determinants of VCT service uptake among adults in SSA. Electronic databases were searched to identify eligible English language publications. Reporting of the study selection procedure was done according to PRISMA and the selected articles were also critically appraised.
View Article and Find Full Text PDFSex-Specific Associations of Testosterone and Genetic Factors With Health Span.
Front Endocrinol (Lausanne)
February 2022
Background: Previous studies have suggested associations between testosterone, genetic factors, and a series of complex diseases, but the associations with the lifespan phenotype, such as health span, remain unclear.
Methods: In this prospective cohort study, we analyzed 145,481 men and 147,733 women aged 38-73 years old from UK Biobank (UKB) to investigate the sex-specific associations of total testosterone (TT), free testosterone (FT), or polygenic risk score (PRS) with health span termination (HST) risk. At baseline, serum testosterone levels were measured.
Objectives: Several dietary patterns are associated with cardiovascular diseases. Traditional, Western, Mediterranean, and vegetarian are common dietary patterns, derived from principal component analysis (PCA) of dietary food intakes associated with cardiovascular diseases; however, these patterns were derived mostly from the diet habits of people in Western and European countries. Therefore, the present study aimed to determine dietary patterns linked with coronary artery disease (CAD) in the Nepalese population.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore the relationship between sleep quality and health span using data from the UK Biobank, involving nearly 329,000 participants aged 37 to 73.
- Participants' health span was assessed based on several serious health conditions, and a sleep quality score was calculated from factors like sleep duration and daytime sleepiness.
- Results indicated that those with good sleep quality had a significantly lower risk (15%) of experiencing health span termination events, suggesting that improving sleep habits could enhance overall health span, with almost 15% of health issues potentially preventable through better sleep.
Objectives: To examine the associations between four sleep behaviors and the risk of healthspan termination.
Methods: This study included 323,373 participants, free of terminated healthspan at baseline, from the UK-Biobank (UKB). We applied multivariable-adjusted Cox regression models to estimate the risk of terminated healthspan based on four sleep behaviors (insomnia/sleeplessness, napping, daytime sleepiness, and difficulty getting up from bed), which were self-reported and measured on Likert scales from "usually" to "never/rarely" experiences.