Does the use of antibiotic spacer disrupt induced membrane function?

Treatment of large segmental bone defects has been a challenging and long process for both physicians and patients. At present, the induced membrane technique is one of the reconstruction techniques commonly utilized in treating large segmental bone defects. It consists of a two-step procedure.

Perioperative alendronate, risedronate, calcitonin and indomethacin treatment alters femoral stem fixation and periprosthetic bone mineral density in ovariectomized rats.

Background: Many factors affect implant stability and periprosthetic bone mineral density (BMD) following total joint arthroplasty. We asked whether perioperative alendronate, risedronate, calcitonin and indomethacine administration altered (1) femoral stem shear strength and periprosthetic bone mineral density BMD in ovariectomized rats and (2) whether there were differences in the effect of these drugs.

Methods: Thirty overiectomized rats were divided into five groups and implanted with intramedullary mini-cortical screws in the femur.

[Effects of short- and long-segment posterior instrumentation on spinal canal remodeling in thoracolumbar vertebra burst fractures].

Background: Spinal canal remodeling results according to Magerl classification and fracture localization after short- and long-segment posterior instrumentation treatment were evaluated in patients with thoracolumbar junction burst fracture.

Methods: Eighty patients were divided into two groups: Group 1: short-segment posterior instrumentation was applied in 36 patients [9F, 27M; Median age: 42.1 (range: 19-65)] and Group 2: long-segment posterior instrumentation was applied in 44 patients [18F, 26M; Median age: 46.