Publications by authors named "Muhammed Cınar"
Objective: To evaluate the development of anti-drug antibodies (ADAb) against tumor necrosis factor inhibitors (TNFi) therapy during a 2-year period and search the factors linked to patients with axial spondyloarthritis (axSpA).
Methods: Biologic-naive patients with axSpA were included in this observational study. Serum drug levels and ADAb were measured at weeks 12, 24, 52, and 104 of treatment by enzyme-linked immunosorbent assay (ELISA).
Article Synopsis
- The study evaluated the mortality rates of patients with Psoriatic Arthritis (PsA) before and during the COVID-19 pandemic by analyzing data from a Turkish registry linked to the Cause of Death Registry.
- Findings revealed that the crude mortality rate in PsA patients doubled during the pandemic, with noticeable increases in both genders but more significant in females.
- The research concluded that pre-pandemic mortality rates for PsA were similar to the general population, but the pandemic has raised concerns about a potential increased mortality risk for PsA patients due to COVID-19, warranting further investigation.
Background/aim: The distribution of Mediterranean fever (MEFV) gene mutations in Turkish familial Mediterranean fever (FMF) patients varies according to geographic area of Turkey. There is a need for highly representative data for Turkish FMF patients. The aim of our study was to investigate the distribution of the common MEFV mutations in Turkish FMF patients in a nationwide, multicenter study.
View Article and Find Full Text PDFArticle Synopsis
- The study looked at Familial Mediterranean fever (FMF), which is a disease where the body has improper inflammation, and focused on mutations in a specific part of the gene called exons.
- Researchers checked data from over 2,200 FMF patients to see how different mutations affected their health.
- They found that patients with mutations in exon 10 had worse symptoms than those with mutations in exon 2, meaning exon 10 mutations are associated with more severe cases of FMF.
Article Synopsis
- The study investigates differences between early onset (≤20 years) and late onset (>20 years) Familial Mediterranean fever (FMF), focusing on patient demographics, clinical features, and genetic variations.
- Out of 2,246 FMF patients in Turkey, 72.7% were in the early onset group, which experienced more severe symptoms and longer diagnosis delays, such as fever and arthritis.
- Genetic analysis revealed that early onset patients had a higher prevalence of M694V mutations, suggesting this mutation may lead to more severe early disease manifestations.
Objective: Approximately 30-45% of patients with familial Mediterranean fever (FMF) have been reported to have attacks despite colchicine treatment. Currently, data on the treatment of colchicine-unresponsive or colchicine-intolerant FMF patients are limited; the most promising alternatives seem to be anti-interleukin-1 (anti-IL-1) agents. Here we report our experience with the off-label use of anti-IL-1 agents in a large group of FMF patients.
View Article and Find Full Text PDF