Publications by authors named "Muhammed A Kizmaz"
The aim of this study is to investigate the diagnostic value of cerebrospinal fluid (CSF) and serum levels of the soluble form of triggering receptor-1 expressed on myeloid cells (sTREM-1) in neonatal meningitis. Serum sTREM-1 levels were measured in all neonatal sepsis patients at the start of antibiotic therapy and the 48th hour of treatment. At the beginning of antibiotic therapy, CSF samples were collected for sTREM-1 measurements.
View Article and Find Full Text PDFObjectives: Juvenile scleroderma is a heterogeneous group of diseases associated with sclerotic skin lesions, grouped as juvenile systemic sclerosis and juvenile localized scleroderma. This study aims to measure the cytokine and chemokine levels involved in interferon (IFN) signalling in patients with juvenile scleroderma and determine their correlation with disease severity.
Methods: Twenty-nine juvenile localized scleroderma, five juvenile systemic sclerosis, and nine healthy controls were included in the study.
Objectives: The aim of our study is to reveal the prevalence of HLA-B*57 in the Turkish population and to provide new perspectives to physicians starting abacavir therapy in HIV patients.
Background: Abacavir, one of the drugs used to treat HIV infection, can cause hypersensitivity reactions in some patients. These hypersensitivity reactions have been shown to be associated with the HLA-B*57:01 allele.
Background: An impaired epithelial barrier integrity in the gastrointestinal tract is important to the pathogenesis of many inflammatory diseases. Accordingly, we assessed the potential of biomarkers of epithelial barrier dysfunction as predictive of severe COVID-19.
Methods: Levels of bacterial DNA and zonulin family peptides (ZFP) as markers of bacterial translocation and intestinal permeability and a total of 180 immune and inflammatory proteins were analyzed from the sera of 328 COVID-19 patients and 49 healthy controls.
Article Synopsis
- Brucellosis is impacted by the interaction between bacteria and the body's immune response, particularly involving new cytokines like IL-35 and IL-39.
- A study measured the levels of these cytokines in patients with acute and chronic brucellosis, as well as healthy controls, finding that both cytokines were lower in brucellosis patients compared to controls, especially in acute cases.
- The research suggests that decreased levels of IL-35 and IL-39 may be linked to a weaker immune response in brucellosis and could contribute to the disease's progression from acute to chronic stages.
Background: Blood components should be gamma-irradiated (γ-IR) in order to prevent transfusion-associated graft-versus-host disease. The aim of this study is to determine the effect of γ-IR and storage time on the exosomes released from apheresis platelet concentrates (aPC) and to investigate their impact on the maximum platelet aggregation (MPA) and hemostasis.
Materials And Methods: Eight units of aPC were included in this study.
Coronavirus disease 2019 (COVID-19) has clinical manifestations ranging from mild symptoms to respiratory failure, septic shock, and multi-organ failure. Lymphocytes are divided into different subtypes based on their cytokine production pattern. In this study, we investigated the role of cytokine expressions of CD4 T (T helper [Th]1, Th2, Th17, Th22) and CD8 T cell subtypes (T cytotoxic [Tc]1, Tc2, Tc17, Tc22) in the pathogenesis of COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of CD39 expression in regulatory T cells (Tregs) and its connection to the severity of COVID-19 in both adults and juveniles.
- Researchers analyzed blood samples from 190 COVID-19 patients and 43 healthy controls using flow cytometry.
- Findings show that CD39 Tregs increase with disease severity in adults but decrease in juveniles, highlighting differences in immune response between age groups.