In vitro evaluation of the toxicity and underlying molecular mechanisms of Janus Fe O -TiO nanoparticles in human liver cells.

Recent studies show that Janus Fe O -TiO nanoparticles (NPs) have potential applications as a multifunctional agent of magnetic resonance imaging (MRI) and photodynamic therapy (PDT) for the diagnosis and therapy of cancer. However, little work has been done on their biological effects. To evaluate the toxicity and underlying molecular mechanisms of Janus Fe O -TiO nanoparticles, an in vitro study using a human liver cell line HL-7702 cells was conducted.

Y receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy.

Due to the molecular and cellular heterogeneity of glioma, discovery of novel targeted sites and ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y1 receptors (Y1Rs) are highly over expressed in various brain tumors including glioma, and can serve as potential targeting sites for glioma imaging and therapy. Here, we show by in vivo fluorescent imaging that a highly selective Y1R ligand, [Asn6, Pro34] NPY (AP-NPY), facilitated circumvention of the blood brain barrier (BBB) by nanomicelles specifically targeting glioma.