Publications by authors named "Muhammad Zain Altaf"
Diabetes mellitus is a multi-systematic chronic metabolic disorder and life-threatening disease resulting from impaired glucose homeostasis. The inhibition of glucosidase, particularly -glucosidase, could serve as an effective methodology in treating diabetes. Attributed to the catalytic function of glucosidase, the present research focuses on the synthesis of sulfonamide-based acyl pyrazoles followed by their and screening against -glucosidase.
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- The World Health Organization has flagged SARS-CoV-2, especially the omicron variant, as a major concern due to its ability to evade vaccines through mutations in the spike protein.
- This study focuses on developing a vaccine that targets specific B- and T-cell epitopes of the virus, utilizing bioinformatics to identify potential candidates based on their immunogenicity and toxicity.
- The researchers constructed a Multi-Epitope Vaccine (MEV) and tested it in E. coli, showing promising immune responses which could offer a new strategy in the fight against SARS-CoV-2 infections.