Publications by authors named "Muhammad Z Awan"
Article Synopsis
- Chemotherapy is the primary treatment for triple-negative breast cancer (TNBC), and there's growing interest in targeting CD73 to enhance immunotherapy effectiveness, as it suppresses anti-cancer immunity.
- CD73 carries a dual role in promoting tumor survival by both inhibiting immune response and enabling the growth of cancer stem cells (CSCs), which may lead to tumor relapse after treatment.
- Researchers conducted in silico screening of compounds and found that quercetin and luteolin, when combined with the chemotherapy drug paclitaxel, effectively downregulated pathways associated with CD73 and CSCs, indicating a potential strategy for improved TNBC treatment outcomes.*
