Binary and ternary complex formation and characterization of artemisinin with sulfobutyl ether β-cyclodextrin and oleic acid.

Drug-resistant malaria is a global risk to the modern world. Artremisinin (ART) is one of the drugs of choice against drug-resistant (malaria) which is practically insoluble in water. The objective of our study was to improve the solubility of artemisinin (ART) via development of binary complexes of ART with sulfobutylether β-cyclodextrins (SBE7 β-CD), sulfobutylether β-cyclodextrins (SBE7 β-CD) and oleic acid (ternary complexes).