Anti-Pyretic, Analgesic, and Anti-Inflammatory Activities of Meloxicam and Curcumin Co-Encapsulated PLGA Nanoparticles in Acute Experimental Models.

Herein, we evaluated the in vivo effects of meloxicam and curcumin co-encapsulated PLGA nanoparticles in experimental acute models of pyrexia, nociception, and inflammation. Seven groups ( = 6) were designed for each investigation and pretreated intraperitoneally (i.p.

Anti-arthritic activity of L. and L. extracts in adjuvant-induced arthritic rats modulating inflammatory mediators and subsiding oxidative stress.

Objectives: This study aimed to evaluate the anti-arthritic activity of leaves' and roots' hydroalcoholic extracts in Complete Freund's adjuvant-induced arthritis in Wistar rats.

Materials And Methods: HPLC and FT-IR analysis detected pharmacologically important phytocompounds in both plant extracts. Oral treatments including methotrexate (MTX; 3 mg/kg twice a week) and extracts at 250 and 500 mg/kg/day were initiated after arthritis induction.