Publications by authors named "Muhammad T Khan"

Background And Aim: Carnitine deficiency contributes to various comorbidities in maintenance hemodialysis (MHD) patients. This study aims to assess the impact of levocarnitine supplementation on hematological and serum iron profile parameters, comparing the efficacy of oral versus intravenous (IV) administration in these patients.

Materials And Methods: This was a multicenter, randomized controlled trial was conducted on patients undergoing MHD at the hemodialysis unit of our study center in Karachi, Pakistan.

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Background: The simultaneous amplification/testing for tuberculosis (SAT-TB) targets specific 16s rRNA for detecting Mycobacterium tuberculosis in real-time.

Objective: To evaluate SAT-TB's performance in detecting intestinal and urinary TB using stool and urine samples.

Methods: Stool (94) and urine samples (69) (From 2021 to 2022), were collected from pulmonary combined with suspected intestinal or urinary tuberculosis.

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The habitat suitability of Salvadora oleoides and Tamarix aphylla can be one of the most significant steps towards conserving these tree species. Habitat loss presents a critical threat to the existence of S. oleoides and T.

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Lipofibromatosis is a rare benign soft tissue tumor that primarily affects children. There is limited cytological description and management of this rare condition in the literature which leads to misdiagnosis. The two years old patient first presented with a big, non-tender swelling on the scalp's right temporoparietal area.

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Background And Objective: Chiari I Malformation-associated syringomyelia (CM) and idiopathic syringomyelia (IS) are often confused together. They require different diagnostic approach and treatment modalities; it is important to distinguish between the two. We aimed to evaluate the radiological and morphologic characteristics of CM and IS in adult and pediatric patients in Pakistani population.

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Gliomas are tumors arising in the central nervous system, frequently associated with Class I mutations and BRAF fusions. These mutations are adverse prognostic factors in juvenile gliomas, leading to high rates of recurrence and poor response to current treatments. The blood-brain barrier and the heterogeneity of gliomas complicate the development of a single treatment strategy for all cases.

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Background: Newcastle disease virus (NDV) is a highly contagious and economically devastating pathogen affecting poultry worldwide, leading to significant losses in the poultry industry. Despite existing vaccines, outbreaks continue to occur, highlighting the need for more effective vaccination strategies. Developing a multi-epitopic peptide vaccine offers a promising approach to enhance protection against NDV.

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Article Synopsis
  • Temporal lobe epilepsy (TLE) is difficult to diagnose due to its varied presentations and reliance on MRIs and EEGs, which may lead to underdiagnosis.
  • Symptoms can include unusual behaviors and psychiatric issues, and treatment with antiepileptic medications should be considered even if tests appear normal.
  • A case study is presented where a patient with behavioral issues and recurrent loss of consciousness, despite normal test results, significantly improved after starting divalproex sodium, demonstrating the need for awareness of TLE indicators.
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Objective: Our meta-analysis aimed to evaluate the safety of procedural sedation and analgesia in pediatric emergency department (ED) settings by investigating the incidence of cardiac, respiratory, gastrointestinal, and neurological adverse events associated with different sedation medications.

Methods: In accordance with PRISMA guidelines, a comprehensive database search for randomized controlled trials was performed across ten databases from January 2005 to June 2024. Our inclusion criteria included randomized controlled trials involving children under 18 years old undergoing pediatric sedation and analgesia in the ED.

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Article Synopsis
  • * CKD is particularly critical for patients with end-stage renal disease (ESRD) who are undergoing maintenance hemodialysis (MHD).
  • * ESRD patients face high rates of health issues and death largely due to the complications from CKD and its impact on heart health.
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The sternal cleft (SC) is a rare congenital anomaly characterized by a complete or partial separation of the sternum, leading to significant clinical concerns, including respiratory and cardiac instability. Due to its rarity, the SC often poses surgical challenges. This case report highlights the management of two neonates with SCs, emphasizing the critical role of early multidisciplinary intervention.

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The hydrogels got hot attention from the researchers due to their excellent flexibility, mechanical properties, conductivity, and response to external stimuli, however, their applications are hampered due to a lack of water retention properties and anti-freezing ability. In this study, the organohydrogel was designed from the two solvents system (DMSO and water) in which acrylamide (Amm) and acrylic acid (AA) work as monomers and Arabic gum (AG) works as biopolymers. The functional groups, surface morphology, mechanical properties, rheological properties, anti-freezing properties, and strain-sensing properties of the fabricated organohydrogel were studied.

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The objective of this study was to determine the optimal timing, sperm concentration, and body condition score (BCS) for laparoscopic artificial insemination (LAI) in the subtropical Lohi sheep breed. In Experiment 1, Lohi ewes (n = 80) were synchronised through progestin-sponges (day 0-day 11), administering PGF2 (d-cloprostenol 75 μg/mL; i.m.

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Non-tuberculous mycobacteria (NTM) are one of major public health concern. The current study aimed to find the prevalence trends of NTM in Guangzhou, China from January 2018 to December 2023. A total of 26,716 positive mycobacterial cultures were collected.

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Environmental pollution due to plastic waste is a global challenge causing adverse impacts on the ecosystem and public health. Microplastic (MP) originates at the upstream processes such as industrial and household activities; however, their existence is affecting the downstream environment. Even though many governments and non-government organizations have taken technological and regulatory steps, these current efforts and strategies are insufficient to prevent the MP release in the environment.

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The discordance between phenotypic and molecular methods of rifampicin (RIF) drug susceptibility testing (DST) in poses a significant challenge, potentially resulting in misdiagnosis and inappropriate treatment. A comparison of RIF phenotypic and molecular methods for DST, including whole genome sequencing (WGS), may provide a better understanding of resistance mechanisms. This study aims to compare RIF DST in using two phenotypic and molecular methods including the GeneXpert RIF Assay (GX) and WGS for better understanding.

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Article Synopsis
  • Olmsted syndrome is a rare genetic disorder that causes severe thickening of the palms and soles, often resistant to traditional treatments.
  • A case study discusses a patient with the condition, showing extensive treatment and surgeries that ultimately led to successful management after 16 years.
  • The case highlights the challenges of Olmsted syndrome and presents a novel surgical strategy that allowed the patient, now a college student, to return to normal daily activities.
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spp. are plant pathogens known for significantly impacting crop yields. Among them, () is notable for colonizing the xylem and causing sugarcane leaf scald disease.

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Glanzmann thrombasthenia and clotting factor VII deficiency are rare autosomal recessive bleeding disorders. But the occurrence of both in the same person is an extremely rare phenomenon. Here, we present the case of a young female from Sindh, Pakistan that got diagnosed with Glanzmann thrombasthenia and concomitant moderate factor VII deficiency, a combination not previously reported in the country.

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Procedural sedation and analgesia (PSA) are a common practice in emergency departments (EDs), aiming to alleviate pain, anxiety, and discomfort during various medical procedures. We have undertaken a systematic review and meta-analysis with the aim of assessing the incidence of adverse events associated with PSA, including those related to individual drugs and various drug combinations. The study adhered to PRISMA guidelines for a systematic review and meta-analysis of adverse events in ED sedation.

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Nontuberculous mycobacteria (NTM) are widespread environmental organisms found in both natural and man-made settings, such as building plumbing, water distribution networks and hospital water systems. Their ubiquitous presence increases the risk of transmission, leading to a wide range of human infections, particularly in immunocompromised individuals. NTM primarily spreads through environmental exposures, such as inhaling aerosolized particles, ingesting contaminated food and introducing it into wounds.

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Background: Extrapulmonary tuberculosis (EPTB) without symptomatic pulmonary involvement has been thought to be non-transmissible, but EPTB with asymptomatic pulmonary tuberculosis (PTB) could transmit tuberculosis (TB). Genomic investigation of Mycobacterium tuberculosis (Mtb) isolates from EPTB may provide insight into its epidemiological role in TB transmission.

Methods: Between January 2017 and May 2020, 107 Mtb isolates were obtained from surgical drainage of bone TB patients at the Beijing Chest Hospital, and 218 Mtb strains were isolated from PTB cases.

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