Publications by authors named "Muhammad Saqib Saif"

Article Synopsis
  • The study developed a drug delivery system using plant extract-coated zeolitic imidazole frameworks (CME@ZIF-8) to enhance silymarin's solubility and bioavailability, demonstrating its protective effects against nephrotoxicity and cardiac toxicity in rats exposed to carbon tetrachloride (CCl).
  • Analysis showed that the new PEG-Sily@CME@ZIF-8 formulation improved antioxidant defenses and reduced damage in the rats, with mechanisms identified through interactions with various proteins related to cellular health.
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Article Synopsis
  • Silymarin, known for its liver-protective and antioxidant benefits, suffers from low oral bioavailability and poor water solubility, impacting its effectiveness as a treatment.
  • The study aimed to enhance silymarin's bioavailability using a novel zeolitic imidazole metal-organic framework (CME@ZIF-8), which was synthesized and optimized to load a significant percentage of silymarin (33.5%).
  • In vivo tests on rats showed that the PEG-Sily@CME@ZIF-8 formulation improved the hepatoprotective effects of silymarin compared to the free compound, helping restore normal antioxidant enzyme levels and cellular function after toxin exposure.
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  • Bacterial infections are increasingly threatening public health, prompting research into effective treatments.
  • A new nanocomposite, CME@ZIF-8, shows improved antibacterial properties compared to its precursor, ZIF-8, and traditional antibiotics like ciprofloxacin.
  • Characterization techniques validate its efficiency, demonstrating that CME@ZIF-8 can significantly reduce bacterial growth, highlighting its potential for treating infectious diseases.
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Herein, silver and zinc oxide Nanoparticles (NPs) were synthesized by using W. coagulant fruit extract as reducing agent and capping agent. The green synthesized NP with distinct properties were used for novel application against fungal and bacterial pathogen of honey bee (A.

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  • The study presents an eco-friendly method for synthesizing nickel oxide nanoparticles (NiONPs) using bioactive compounds from a plant stem extract (BBS), known for its high content of phenolics, flavonoids, and berberine.
  • Various analytical techniques confirmed the formation and characteristics of the nanoparticles, demonstrating their size and elemental composition.
  • BBS-NiONPs displayed significant antioxidant properties, cytotoxic effects against brine shrimp, and the ability to inhibit bacterial and fungal growth, along with enhancing seed germination and growth, indicating their potential for biomedical and agricultural applications.
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In current report, nickel oxide nanoparticles (NiONPs) were synthesized using leaf extract of Berberis balochistanica (BB) an endemic medicinal plant. The BB leaves extract act as a strong reducing, stabilizing, and capping agent in the synthesis of BB@NiONPs. Further, BB@NiONPs were characterized using Uv-visible spectroscopy (UV-vis), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), and average size was calculated ~21.

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Despite of broad range application, the cost effective, highly stable and reproduceable synthesis of ZnO is needed, especially which can make it biosafe as well. Here, a unique bioinspired synthesis of ZnO nanoflowers (NFs) has been introduced using Withania coagulans extract as reducing agent. Different molar concentrations were assessed to counter the effect of structural, morphological, antibacterial activity and high efficiency of algae harvesting.

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Present work compares the green synthesis of iron oxide nanorodes (NRs) using Withania coagulans and reduction precipitation based chemical method. UV/Vis confirmed the sharp peak of Iron oxide NRs synthesized by biologically and chemically on 294 and 278 nm respectively. XRD and SEM showed highly crystalline nature of NRs with average size 16 ± 2 nm using Withania extract and less crystalline with amorphous Nanostructure of 18 ± 2 nm by chemical method.

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