Corrigendum: Apoptotic effect of novel Schiff Based CdCl(CHNO) complex is mediated via activation of the mitochondrial pathway in colon cancer cells.

This corrects the article DOI: 10.1038/srep09097.

Apoptotic effect of novel Schiff based CdCl₂(C₁₄H₂₁N₃O₂) complex is mediated via activation of the mitochondrial pathway in colon cancer cells.

The development of metal-based agents has had a tremendous role in the present progress in cancer chemotherapy. One well-known example of metal-based agents is Schiff based metal complexes, which hold great promise for cancer therapy. Based on the potential of Schiff based complexes for the induction of apoptosis, this study aimed to examine the cytotoxic and apoptotic activity of a CdCl2(C14H21N3O2) complex on HT-29 cells.

Acute oral toxicity evaluations of some zinc(II) complexes derived from 1-(2-salicylaldiminoethyl)piperazine Schiff bases in rats.

The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, (1)H NMR, (13)C NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compounds was performed orally to the rats at the single doses of 2000 mg/kg and they were then monitored for possible side effects, mortality or behavioral changes up to 14 days.

Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin.

Ethnopharmacological Relevance: Turnera diffusa Willd. ex Schult. has been used for the treatment of several human disorders including peptic ulcer.

Gastroprotective activity and mechanism of novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl)piperazin-1-iumphenolate complex on ethanol-induced gastric ulceration.

Zinc complexes were reported to have anti-ulcer activity and used as drug for the treatment of gastrointestinal disorders. A novel compound dichlorido-zinc(II)-4-(2-(5-methoxybenzylidene amino)ethyl)piperazin-1-iumphenolate (ZnHMS) was synthesized, characterized and evaluated for its gastroprotective activity against ethanol-induced ulcer in rats. Gross and microscopic lesions, histochemical staining of glycogen storage, biochemical and immunological parameters were taken into consideration.

4-(2-Azaniumyl-eth-yl)piperazin-1-ium bis(perchlorate).

In the title compound, C(6)H(17)N(3) (2+)·2ClO(4) (-), the piperazine ring adopts a chair conformation with the ethyl-ammonium fragment occupying an equatorial position. In the crystal, the dications and perchlorate anions are linked through N-H⋯O hydrogen bonding and weak C-H⋯O hydrogen bonding into a three-dimensional supra-molecular network.

Dichlorido(4-meth-oxy-2-{[2-(piperazin-4-ium-1-yl)eth-yl]imino-meth-yl}phenol-ate)cadmium.

In the title compound, [CdCl(2)(C(14)H(21)N(3)O(2))], the Schiff base ligand chelates the Cd(II) ion in an N,N,O-tridentate fashion. Two Cl atoms complete a distorted square-pyramidal coordination environment around the metal atom. In the crystal, adjacent mol-ecules are linked through C-H⋯π inter-actions into infinite chains along the a axis.

Dichlorido(2-{[2-(piperazin-4-ium-1-yl)eth-yl]imino-meth-yl}phenolate)cadmium(II).

In the title compound, [CdCl(2)(C(13)H(19)N(3)O)], the Cd(II) ion is penta-coordinated with the N,N,O-tridentate Schiff base 2-{[2-(piperazin-4-ium-1-yl)eth-yl]imino-meth-yl}phenolate ligand and two Cl atoms in a highly distorted square-pyramidal geometry; the piperazine ring adopts a chair conformation. In the crystal structure, adjacent mol-ecules are linked together via N-H⋯O and N-H⋯Cl hydrogen bonds, forming infinite layers parallel to the ab plane. The layers are further connected through C-H⋯Cl inter-actions into a three-dimensional network.

(1R,2R)-N,N'-Bis[1-(2-pyrid-yl)ethyl-idene]cyclo-hexane-1,2-diamine.

In the title compound, C(20)H(24)N(4), the cyclo-hexane ring adopts a chair conformation with the two imine groups linked at equatorial positions. The two halves of the mol-ecule are related by a crystallographic twofold rotation axis. The dihedral angle between the pyridine rings is 75.

Dichlorido{N,N-dimethyl-N'-[1-(2-pyrid-yl)ethyl-idene]ethane-1,2-diamine-κN,N',N''}copper(II).

In the title compound, [CuCl(2)(C(11)H(17)N(3))], the Cu(II) ion is five-coordinated with a distorted square-pyramidal configuration. The three N atoms of the Schiff base ligand and one Cl atom are located in the basal plane, whereas the other Cl atom is apically positioned.