Human In Vitro Models of Epilepsy Using Embryonic and Induced Pluripotent Stem Cells.

The challenges in making animal models of complex human epilepsy phenotypes with varied aetiology highlights the need to develop alternative disease models that can address the limitations of animal models by effectively recapitulating human pathophysiology. The advances in stem cell technology provide an opportunity to use human iPSCs to make disease-in-a-dish models. The focus of this review is to report the current information and progress in the generation of epileptic patient-specific iPSCs lines, isogenic control cell lines, and neuronal models.

Alpha-lipoic acid analogues in the regulation of redox balance in epilepsy: A molecular docking and simulation study.

Objective: Oxidative stress is one of the pathophysiological mechanisms implicated in drug-resistant epilepsy. Recurrent seizures and prolonged treatment with anti-seizure medicines (ASMs) can produce reactive oxygen species (ROS) resulting in neuronal cell damage, cell toxicity, and cell death. This damage may contribute to the loss of efficacy of anti-seizure medicines.

Motion-Encoded Electric Charged Particles Optimization for Moving Target Search Using Unmanned Aerial Vehicles.

In this paper, a new optimization algorithm called motion-encoded electric charged particles optimization (ECPO-ME) is developed to find moving targets using unmanned aerial vehicles (UAV). The algorithm is based on the combination of the ECPO (i.e.

Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis.

Background: Cutaneous adverse drug reactions (cADRs) are one of the most common, severe, and life-threatening types of adverse reactions following treatment with antiseizure medications (ASMs). Some studies have reported a higher incidence of ASM-induced cADRs in females than in males.

Objective: This study sought to perform a systematic review, meta-analysis, and meta-regression to compare the ASM cADR risks between females and males.

Optimizing Router Placement of Indoor Wireless Sensor Networks in Smart Buildings for IoT Applications.

Internet of Things (IoT) is characterized by a system of interconnected devices capable of communicating with each other to carry out specific useful tasks. The connection between these devices is ensured by routers distributed in a network. Optimizing the placement of these routers in a distributed wireless sensor network (WSN) in a smart building is a tedious task.

The effects of cell therapy on seizures in animal models of epilepsy: protocol for systematic review and meta-analysis of preclinical studies.

Background: Epilepsy is one of the most common and serious brain conditions, characterised by recurrent unprovoked seizures. It affects about 1% of the population worldwide. Despite a range of antiepileptic drugs being available, one third of the patients do not achieve adequate seizure control.

Epigallocatechin Gallate as an anti-obesity therapeutic compound: an in silico approach for structure-based drug designing.

Epigallocatechin gallate is a polyphenol of tea plants. Other than tea its trace amounts are found in apple skin, onions and plums. It has anti-adipogenic and anti-oxidant potential.

Potential of Stem Cells as Regenerative Medicine: From Preface to Advancements.

Regenerative medicine is an emerging field to find solutions to some of the most challenging medical problems of humans. Regenerative medicine has the potential to revolutionize the whole health care system, in dealing with conditions such as heart disease, emphysema, liver fibrosis, kidney disease, diabetes, and neurological disorders. Among the many challenges to bringing regenerative medicine to the clinic is the selection of the best cell types and reliable ways to expand the number of cells.