Anti-metastasis Effects and Mechanism of Action of Curcumin Analog (2E,6E)-2,6-bis(2,3-dimethoxybenzylidene) Cyclohexanone (DMCH) on the SW620 Colorectal Cancer Cell Line.

Background: Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths. Curcumin has been reported to have suppressive effects in CRC and to address the physiological limitations of curcumin, a chemically synthesized curcuminoid analog, known as (2E,6E)-2,6-Bis (2,3-Dimethoxy benzylidine) cyclohexanone (DMCH), was developed and the anti-metastatic and anti-angiogenic properties of DMCH in colorectal cell line, SW620 were examined.

Methods: The anti-metastatic effects of DMCH were examined in the SW620 cell line by scratch assay, migration, and invasion assay, while for anti-angiogenesis properties of the cells, the mouse aortic ring assay and Human Umbilical Vein Endothelial Cells (HUVEC) assay were conducted.

Optimization of ultrasonically extracted β-sitosterol from using response surface methodology.

genus is recognized as a significant source of β-sitosterol and polyphenols. The inclusion of β-sitosterol into various health-related formulations has widened its potential in the pharmaceutical and nutraceutical industries. Process optimization ensures the maximum efficiency, consistency, and yield.

Remarkable enhancement of the nonlinear optical behavior towards asymmetric substituted D-π-A dithiophene-based compounds.

Context: Nonlinear optics (NLO) is an interesting field that discloses the interaction between intense light and matter, leading to a deeper understanding of NLO phenomena. Organic chromophores are considered as promising materials for NLO due to their exceptional structural versatility, ease of processing, and rapid response to NLO effects. Functional materials based on thiophene have been indispensable in advancing organic optoelectronics.

2D MXene-Based Nanoscale Materials for Electrochemical Sensing Toward the Detection of Hazardous Pollutants: A Perspective.

MXenes (MXT), a subgroup of 2-dimensional (2D) materials, specifically comprise transition metal carbides, nitrides, and carbonitrides. They exhibit exceptional electrocatalytic and photocatalytic properties, making them well-suited for the detection and removal of pollutants from aqueous environments. Because of their high surface area and remarkable properties, they are being utilized in various applications, including catalysis, sensing, and adsorption, to combat pollution and mitigate its adverse effects.

An Oxalato-Bridged Cu(II)-Based 1D Polymer Chain: Synthesis, Structure, and Adsorption of Organic Dyes.

In the current research, we prepared a polymeric framework, {[Cu(CO)(CHN)]·HO·0.67(CHOH)]} () (where CO = oxalic acid; CHN = 2,2-bipyridine), and explored this compound for adsorption of methylene blue (MB) and methyl orange (MO). The crystal structure of the compound consists of a Cu(ox)(bpy) unit connected via oxalate to form a 1D polymeric chain.

Formulation of biodegradable alginate-based nano-carriers for in-vitro drug delivery and antibacterial activity.

Evaluation of the controlled release of ciprofloxacin (CIP.HCl) and the antibacterial efficacy of alginate (ALG)-based nanocarriers constitute the primary objectives of the current work. Herein, ALG-based nano-structures were prepared by the co-precipitation method and thoroughly analyzed using different characterization techniques, i.

Remediation of organic pollutant from the aqueous environment using in-house fabricated polyaniline-based hybrid composite (PANI-MnPBA/NiCoMnS) materials.

Polyaniline-based hybrid material (PANI-MnPBA/NiCoMnS) was prepared by hydrothermal-solvothermal approach. Synthesized hybrid material was characterized through FTIR-spectroscopy, p-XRD, SEM, EDX, BET, and Zetasizer techniques. Hybrid material as adsorbent for removal of Congo red (CR) from water system showed excellent results such as 98 % removal efficiency and 254 mg/g adsorption capacity.

A review of current evidence on food allergies during pregnancy.

Food allergy is the reaction of the immune system of the body that occurs after consuming specific foods. During specific physiological ages of pregnancy, women are more prone to different allergic reactions and mostly these reactions may prolong and have long-term effects. The hypersensitivity of different types of allergens is mainly linked with the adversity of reactions.

Unveiling -Alkyloxy/-Silyloxy-Substituted -Aryl PNP Ligands for Efficient Cr-Catalyzed Ethylene Tetramerization.

Novel -aryl-functionalized PNP ligands () bearing -alkyloxy/-silyloxy substituents were prepared and evaluated for chromium-catalyzed ethylene oligomerization using MMAO-3A as an activator. The selected Cr/PNP system under optimized condition exhibited high 1-octene-selective (up to 70 wt %) ethylene tetramerization at a remarkable rate (over 3000 kg gCr h). More importantly, the undesirable polyethylene selectivity was restricted to a minimum level of ∼1-2 wt % for pre-catalysts derived with ligands and .

Functional profile and encapsulating properties of Colocasia esculenta (Taro).

Especially in tropical and subtropical countries, tuber and root crops have developed into important food crops. Due to its use in food preparation, aesthetics, and medicine, taro () is ranked as the fifth most important root crop. In comparison, it stores a considerable quantity of starch - even more than potatoes, sweet potatoes, cassava, and other similar crops.

Oleuropein: Chemistry, extraction techniques and nutraceutical perspectives-An update.

Olive family (Oleaceae) contains several species among which L. is mostly used for production of olive oils. Various parts of olive tree are rich source of diverse bioactive compounds such as Apigenin, elenolic acid, Hydroxytyrosol, Ligstroside, Oleoside, Oleuropein, Oleuropein aglycone, Tyrosol, etc.

Gut microbiota and synbiotic foods: Unveiling the relationship in COVID-19 perspective.

The Coronavirus disease 2019 (COVID-19) has spread across the globe and is causing widespread disaster. The impact of gut microbiota on lung disease has been widely documented. Diet, environment, and genetics all play a role in shaping the gut microbiota, which can influence the immune system.

Probiotics encapsulated gastroprotective cross-linked microgels: Enhanced viability under stressed conditions with dried apple carrier.

In the current study, was encapsulated in sodium alginate and whey protein isolate, with the addition of antacids CaCO or Mg(OH). The obtained microgels were observed by scanning electron microscopy. Encapsulated and free probiotics were subjected to vitality assay under stressed conditions.

Bad apples spoiling the metaphor? How and why self-serving leaders stir up counterproductive behaviors at work.

Self-serving leaders satisfy their self-interests at the cost of both employees and organizations, leading to declining organizational competitive advantage and performance. Drawing upon the affective events theory (AET), we constructed and examined a theoretical model of self-serving leadership influencing counterproductive work behavior (CWB), where traditionality plays a significant moderating role through the lens of anger as a mediator. Data were collected in three waves using a survey questionnaire distributed in three industries located in the Southwest district of China.

Characterization of ultrasonically extracted flaxseed polysaccharide gum and assessing its lipid-lowering potential in a rat model.

Flaxseed polysaccharide gum (FPG) was extracted through the ultrasound-assisted process using water as a solvent with a yield ranging from 8.05 ± 0.32% to 12.

Authoritarian leadership and cyberloafing: A moderated mediation model of emotional exhaustion and power distance orientation.

Drawing upon the conservation of resource theory (COR), this study proposes a moderated mediation model of authoritarian leadership on subordinates' cyberloafing. Paired samples of 360 employees working in 103 teams from Chinese companies were collected at 2 points in time. The results show that authoritarian leadership positively affects subordinates' cyberloafing and this relationship is mediated by emotional exhaustion.

A rational approach towards selective ethylene oligomerization PNP-ligand design with an -triptycene functionality.

Novel PNP ligands bearing an -triptycene backbone were developed and evaluated for selective ethylene oligomerization. Upon activation with MMAO-3A, the pre-catalyst mixture containing Cr(acac)/ligand efficiently promotes ethylene tetramerization with remarkably high productivities (up to 1733 kg g h) and C olefin selectivities (up to 74.1 wt%).

Humor at work that works: A multi-level examination of when and why leader humor promotes employee creativity.

Although the role of leadership in fostering employee creativity has been extensively studied, it is still unclear whether and how leader humor affects employee creativity. Drawing upon cultural representation theory (CRT), we examined creative self-efficacy as a mediator and traditionality as a situational factor in the relationship between leader humor and employee creativity by analyzing a sample of 306 employees and 88 leaders (paired data) collected through survey questionnaire from firms based in Hubei Province, China, covering the industries of automobile, IT, and medicine. Following the multi-level examination, leader humor was positively related to employee creativity, and creative self-efficacy was found to mediate the impact of leader humor on employee creativity.

A new hexanuclear Fe(III) nanocluster: synthesis, structure, magnetic properties, and efficient activity as a precatalyst in water oxidation.

The oxo-bridged hexanuclear iron cluster formulated [FeIII6(μ-O)(edteH)(piv)(SCN)]·2MeCN·2HO (1) (where edteH = ,,','-tetrakis(2-hydroxyethyl)ethylenediamine; piv = pivalic acid) has been synthesized by the reaction of FeCl·4HO with edteH and piv in the presence of KSCN in CHCl/MeCN. The single crystal X-ray measurements indicated that the cluster is centrosymmetric in structure. The magnetic study demonstrated the presence of very strong antiferromagnetic coupling between the iron centers and the Brillouin fitting showed the best fit with = 5/2 and = 1.

An Overview of Synthetic Routes of Pharmaceutically Important Pyranopyrazoles.

Pyranopyrazoles are bicyclic nitrogen-containing heterocycles having broadspectrum bioactivities, which may act as anti-cancer, anti-inflammatory, antibacterial, antifungal, insecticidal and molluscicidal agents. Pyranopyrazoles have become an attractive scaffold for the discovery of new drugs due to the diverse range of bioactivities associated with this nucleus. In this review, we have focused on the medicinal importance of pyranopyrazole derivatives and highlighted different routes for the synthesis of pyranopyrazole derivatives using inexpensive and commonly available starting materials.

Highly Efficient Ethylene Tetramerization Using Cr Catalysts Constructed with Trifluoromethyl-Substituted -Aryl PNP Ligands.

Tetramerization of ethylene by chromium catalysts stabilized with functionalized -aryl phosphineamine ligands CH(-CF)N(PPh) (), CH(-CF)N(PPh) (), CH(-CF)N=PPh-PPh (), and CH(3,5-bis(CF))N(PPh) () was evaluated. The parameter optimization includes temperature, co-catalyst, and solvent. Upon activation with MMAO-3A, the new catalyst system especially with -functional PNP ligand () exhibited high 1-octene selectivity and productivity while giving minimum undesirable polyethylene and C olefin by-products.

Negative Influences of Differentiated Empowering Leadership on Team Members' Helping Behaviors: The Mediating Effects of Envy and Contempt.

Purpose: Given the popularity of empowerment practices among scholars and practitioners, this research examines whether a manager's differentiated empowering leadership negatively affects team members' helping behaviors and, if so, how.

Methods: The authors conducted one multi-source and time-lagged survey (with 44 managers and 212 team members) and two scenario-based experiments (with 120 participants in Study 2 and 121 participants in Study 3) to test the research model.

Results: Team managers' differentiated empowering leadership decreases team members' helping behaviors.