A population study has been performed for Pakistani ballpoint pen inks of blue, black, red, and green colors (a total of four colors) commercially used in Pakistan. Ballpoint pen inks have been investigated and discriminated by using UV/Vis spectroscopy and FTIR spectroscopy. We have calculated and compared the results in terms of discriminating power (DP).
View Article and Find Full Text PDFIn developing countries, the chances of fraud in written documents are comparatively high. Therefore, comparison of fountain pen inks is especially imperative in examination of forensic questioned documents. We have investigated the use of the gas chromatography-mass spectrometry technique in profiling and discrimination of fountain pen ink used in Pakistan for forensic purpose.
View Article and Find Full Text PDFIn this article, a synthesis of '-(benzylidene)-2-(6-methyl-1-pyrazolo[3,4-]quinolin-1-yl)acetohydrazides and their structural interpretation by NMR experiments is described in an attempt to explain the duplication of some peaks in their H- and C-NMR spectra. Twenty new 6-methyl-1-pyrazolo[3,4-]quinoline substituted -acylhydrazones (-) were synthesized from 2-chloro-6-methylquinoline-3-carbaldehyde () in four steps. 2-Chloro-6-methylquinoline-3-carbaldehyde (1) afforded 6-methyl-1-pyrazolo[3,4-]quinoline (), which upon -alkylation yielded 2-(6-methyl-1-pyrazolo[3,4-]quinolin-1-yl)acetate ().
View Article and Find Full Text PDFAlzheimer's disease (AD), a progressive neurodegenerative disorder, characterized by central cognitive dysfunction, memory loss, and intellectual decline poses a major public health problem affecting millions of people around the globe. Despite several clinically approved drugs and development of anti-Alzheimer's heterocyclic structural leads, the treatment of AD requires safer hybrid therapeutics with characteristic structural and biochemical properties. In this endeavor, we herein report a microwave-assisted synthesis of a library of quinoline thiosemicarbazones endowed with a piperidine moiety, achieved via the condensation of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes and (un)substituted thiosemicarbazides.
View Article and Find Full Text PDFWith the increased number of multi-drug formulations, there is a need to develop new methods for simultaneous determinations of drugs. A precise, accurate and reliable liquid chromatographic method was developed for simultaneous determination of paracetamol, thiamine, and pyridoxal phosphate in pharmaceutical formulations. Separation of analytes was carried out with an Agilent Poroshell C18 column.
View Article and Find Full Text PDFNew Findings: What is the central question of this study? What is the mechanism of wheat-induced pulmonary inflammation and how does a hydrazide derivative modulate it? What is the main finding and its importance? A hydrazide derivative significantly reduced wheat-induced pulmonary inflammation in a rat model mainly by down-regulating inflammatory cell infiltration, pathological lesions in the lungs and the level of pro-inflammatory cytokines, COX-1, COX-2 and T-cell proliferation.
Abstract: We investigated the ameliorative anti-inflammatory effect of a previously synthesized hydrazide derivative (N'-(4-methoxybenzylidene)-6-(4-chlorophenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide; MD) as an immunomodulator in a newly developed allergen-induced pulmonary inflammation (AIPI) rat model. Wheat and thresher dust were used as allergens to induce pulmonary inflammation while MD was used to reverse the inflammatory response.
Gasoline-ethanol (gasohol) fuel blends have gained considerable attention in the petroleum and energy sectors as relatively cheaper and greener high-octane alternative fuels with gasoline-comparable efficiency in modern transportation vehicles. However, due to different combustion rates the relative concentration of ethanol in gasohol fuel blends may vary over time. Furthermore, there is a need to monitor ethanol concentration in fuel blends for quality control applications.
View Article and Find Full Text PDFIn the present study, a newly developed method based on ultrahigh performance liquid chromatography (UHPLC) was optimized for the simultaneous determination of antazoline hydrochloride (ANZ) and naphazoline hydrochloride (NFZ) in ophthalmic formulations. Isocratic separation of ANZ and NFZ was performed at 40 °C with an ACE Excel 2 C18-PFP column (2 μm, 2.1 × 100 mm) at a flow rate of 0.
View Article and Find Full Text PDFMedchemcomm
February 2017
Two new series of pyrazolobenzothiazine-based carbothioamides ( and ) were synthesized using saccharin as the starting material. The synthesized derivatives were investigated for their ability to inhibit monoamine oxidases (MAO). Compound was found to be a very potent MAO-A inhibitor with an IC value of 0.
View Article and Find Full Text PDFBreast cancer (BC) is the most common malignancy of women worldwide. In the past it was considered as disease of older middle aged women, but the incidence of BC in young females is growing in recent years concordant with studies in Pakistan. In this paper, we reviewed the mutant functions of tumor suppressor genes (BRCA1, BRCA2, p53, ATM and PTEN), epigenetic transformation and involvement of estrogen receptors in development of breast cancer.
View Article and Find Full Text PDFBiosens Bioelectron
December 2015
Inorganic mercury and arsenic encompasses a term which includes As(III), As(V) and Hg(II) species. These metal ions have been extensively studied due to their toxicity related issues. Different analytical methods are used to monitor inorganic mercury and arsenic in a variety of samples at trace level.
View Article and Find Full Text PDFInt J Biol Macromol
September 2015
Biopolymer based pH-sensitive hydrogels were prepared using chitosan (CS) with polyethylene glycol (PEG) of different molecular weights in the presence of silane crosslinker. The incorporated components remain undissolved in different swelling media as they are connected by siloxane linkage which was confirmed by Fourier transform infrared spectroscopy. The swelling in water was enhanced by the addition of higher molecular weight PEG.
View Article and Find Full Text PDFIn the present study a novel biomass, derived from the pulp of Saccharum bengalense, was used as an adsorbent material for the removal of Pb (II) ions from aqueous solution. After 50 minutes contact time, almost 92% lead removal was possible at pH 6.0 under batch test conditions.
View Article and Find Full Text PDFMolecular imprinting is a well-established technology to mimic antibody-antigen interaction in a synthetic platform. Molecularly imprinted polymers and nanomaterials usually possess outstanding recognition capabilities. Imprinted nanostructured materials are characterized by their small sizes, large reactive surface area and, most importantly, with rapid and specific analysis of analytes due to the formation of template driven recognition cavities within the matrix.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
February 2012
The asymmetric unit of the title compound, C(11)H(10)ClN(3)O, contains two geometrically different mol-ecules, A and B, in both of which the pyridazine rings are essentially planar with r.m.s.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
April 2011
The asymmetric unit of the title compound, C(9)H(11)ClN(4), contains two virtually planar mol-ecules that differ in conformation about the bond connecting the hydrazine and pyridazine units. The 3-chloro-6-hydrazinylpyridazine and cyclo-pentane groups are oriented at dihedral angles of 4.5 (3) and 8.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
August 2010
In the title compound, C(10)H(10)ClN(5)O(2), the dihedral angle between the aromatic rings is 0.16 (9)°. Two S(6) ring motifs are formed due to intra-molecular N-H⋯N and N-H⋯O hydrogen bonds.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
August 2010
In the title compound, C(7)H(9)ClN(4), the 3-chloro-6-hydrazinylpyridazine unit is planar (r.m.s.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
July 2010
Two independent mol-ecules are present in the asymmetric unit of the title compound, C(12)H(11)ClN(4), (Z' = 2): the dihedral angles between the phenyl and pyridizine rings are 8.35 (10) and 37.64 (6)°.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
July 2010
The title compound, C(7)H(5)ClN(4), is almost planar (r.m.s.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
July 2010
In the title compound, C(14)H(13)N(5), the pyrazole ring is disordered over two orientations in a 0.571 (10):0.429 (10) ratio and the dihedral angle between the pyridazine ring and the benzene ring is 28.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
September 2010
The asymmetric unit of the title compound, C(8)H(11)ClN(4), contains two independent mol-ecules (A and B) with slightly different conformations: the dihedral angles between the 3-chloro-6-hydrazinylpyridazine units and butyl side chains are 4.5 (2) and 11.98 (16)°.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
September 2010
In the title compound, C(9)H(9)ClN(4), the dihedral angle between the aromatic rings is 6.25 (9)°. The whole mol-ecule is approximately planar (r.
View Article and Find Full Text PDFThe mol-ecule of title compound, C(13)H(11)N(5), is essentially planar (r.m.s.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
June 2009
The title compound, C(14)H(13)N(5), crystallizes with two crystallographically independent mol-ecules in the unit cell. The two mol-ecules form dimers through inter-molecular N-H⋯N and C-H⋯N hydrogen bonds. The hydrogen-bonding motifs are R(2) (2)(8) for both the N-H⋯N and C-H⋯N inter-actions.
View Article and Find Full Text PDF