Deciphering molecular basis of pesticide-induced recurrent pregnancy loss: insights from transcriptomics analysis.

Recent studies have revealed a notable connection between pesticide exposure and Recurrent Pregnancy Loss (RPL), yet the precise molecular underpinning of this toxicity remains elusive. Through the alignment of Differentially Expressed Genes (DEGs) of healthy and RPL patients with the target genes of 9 pesticide components, we identified a set of 12 genes responsible for RPL etiology. Interestingly, biological process showed that besides RPL, those 12 genes also associated with preeclampsia and cardiovascular disease.

Phytochemical, antioxidant, and antibacterial activity of nanosuspension against peri-implantitis bacteria: An in vitro study.

Objective: the leaf (MO) has active compounds that may be beneficial for peri-implantitis therapy. This research aims to analyze the phytochemical, antioxidant, and antibacterial properties of L. nanosuspension (MON) extract in peri-implantitis-related bacteria.

Anti-Peri-implantitis Bacteria's Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study.

Objective:  This study was aimed to investigate RGCBE extract as antioxidant and anti-peri-implantitis bacteria through study and its potential as antioxidant, antibacterial, anti-inflammatory, antibone resorption, and proosteogenic through study.

Materials: AND METHODS:  Absorption, distribution, metabolism, excretion and toxicity prediction, molecular docking simulation, and visualization of chlorogenic acid (CGA) and coumaric acid (CA) as anti-inflammatory, antioxidant, and antibacterial were investigated . Inhibition zone by diffusion method, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) of RGCBE extract against (Aa), (Pg), (Fn), and (Pi) were done.

The Effect of Centella asiatica Methanolic Extract on Expression of IL-1β Proinflammatory Cytokines in Severe Early Childhood Caries.

Objective:  This article analyzes the role of extract in reducing the proinflammatory cytokine interleukin (IL)-1β produced by salivary neutrophils.

Material And Methods:  Selected kindergartens in the Surabaya area provided samples. The sample was initially checked for dental caries by measuring its def-t index, and then the participants who satisfied the requirements for severe caries with a def-t of greater than 6 were chosen.

The efficacy of okra fruit extract on the expression of transforming growth factor beta 1 in the tooth socket of diabetic Wistar rats.

Background: Patients with diabetes mellitus suffer from an additional macrophage dysfunction in the secretion of growth factor, which later decreases transforming growth factor beta 1 (TGF-β1). This condition disrupts proliferation and angiogenesis. Extract of okra fruit () contains flavonoid, an active substance which acts as antioxidant, anti-inflammation, and antidiabetes.

Sleep Time Duration Does Not Affect Oral Inflammation and Periodontal Health Status in Night-Shift Workers: A Cross-Sectional Study.

Background: Night-shift workers experience circadian rhythm disruption, changes in sleep time duration, and effects on their eating habits. All these factors may be related to the release of inflammatory mediators and may affect oral inflammation and periodontal health status. The objective of this study was to analyze the effects of sleep time duration on oral inflammation and periodontal health status in night-shift workers and non-night-shift workers.

Analysis of lymphocyte T(CD4) cells expression on severe early childhood caries and free caries.

Early childhood caries (ECC) is still one of the many diseases found in children throughout the world. Cariogenic bacteria are a significant risk factor for ECC associated with early colonization and high levels of cariogenic microbes (, ). Lymphocyte T (CD4) cells known as helper T cells, are effector cells for mediated host immunity.

Expression of fibroblast cells after extraction of wistar rat teeth after topical application of okra fruit () gel.

Background: Tooth extraction is a dental procedure for removing a teeth from the alveolar bone socket. The tooth extraction process causes damage to hard tissue and soft tissue, so the body will respond physiologically to heal the wound. The wound healing process is divided into several phases, one of which is the proliferation phase of fibroblasts, which is one of the most important phases in the process of wound healing.

Complement Receptor 1 (CR1)/ CD35+ Expression Analysis of Salivary Neutrophils on Phagocytosis.

Background: Severe early childhood caries (S-ECC) is a form of dental caries which is very destructive in early childhood since involving several teeth, include the maxillary anterior teeth. Streptococcus mutans (S. mutans) play an etiological integral role of ECC so that S.

CD89/CD35 Expression Ratio in Salivary Neutrophil as an Early Detection Marker for Severe Early Childhood Caries.

Objectives:  To analyze CD35/CD89 expression ratio on the surface of neutrophils as an early detection marker for S-ECC.

Materials And Methods:  Saliva was collected from 4- to 6-year-old kindergarten students. Salivary neutrophils were obtained by instructing the subjects to rinse their mouth with 1 mL of sterile 1.

Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice.

Background: The prevalence of cardiovascular disease (CVD) and its mortality continues to increase. Various studies have shown aspirin can reduce CVD mortality but has adverse side effects. Research on a comparison between aspirin and honey has not been done, but both have antiplatelet effects.

Correlation between human neutrophil peptide 1-3 secretion and azurophilic granule (CD63) expression in early childhood caries.

Background: In saliva, neutrophil constitutes the most prominent first-line defense of immune cells against pathogenic microbes. The importance of neutrophils to the host immune systems of neutropenic or patients disabled with regard to their neutrophil function results in a tendency toward serious infections, such as early childhood caries (ECC). The cytoplasmic granules present in neutrophils play a major role in neutrophil-mediated inflammation.