Publications by authors named "Muhammad Khurshid"

Article Synopsis
  • This study reviews predictors of intra-abdominal injury in pediatric patients with blunt abdominal trauma using data from a Level II trauma center from 2018 to 2022.
  • It found that while various clinical signs and laboratory results were present, a significant number of patients with intra-abdominal injuries (IAI) did not show abnormal lab results, highlighting the complexity in diagnosis.
  • Key independent predictors for IAI included abdominal tenderness, abnormal plain x-rays, and positive ultrasound, suggesting that physical exams and imaging are critical in decision-making for CT scans, rather than relying solely on lab results.
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Background: Failure to rescue (FTR) is an indicator of the quality of care provided by trauma centers. The aim of this study was to examine the trends of FTR incidence in geriatric trauma patients over the years and to determine whether race, ethnicity, and sex impact the FTR incidence.

Methods: This is a retrospective analysis of the American College of Surgeons Trauma Quality Improvement Program database over 4 years (2017-2020).

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Objectives: Ultrasonographic assessment of giant cell arteritis (GCA) relies on the demonstration of a non-compressible halo. Several ultrasonographic methods have been developed to quantify arterial wall thickness, however arterial compressibility has not been quantified. This study presents a possible solution for quantifying compressibility to assist in diagnosing GCA.

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Introduction: Gallstone ileus is an infrequent complication of cholelithiasis with no specific guidelines for its management. This study aims to compare the outcomes of patients with gallstone ileus managed with both enterolithotomy with cholecystectomy (EL-CCY) versus those managed with enterolithotomy (EL) only.

Methods: In this retrospective analysis of 2011-2017 Nationwide Readmissions Database, all patients with an index admission diagnosis of gallstone ileus were included.

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Article Synopsis
  • Tartary buckwheat has strong adaptive capabilities but struggles with drought stress, which impacts crop yields.
  • A study identified a gene, FtPMEI13, that enhances drought tolerance by influencing antioxidant enzyme activities and interacting with pectin methylesterase to manage cell wall composition and stomatal closure.
  • Higher expression levels of FtPMEI13 and its transcription factor, FtbZIP46, are linked to increased drought tolerance in certain Tartary buckwheat genotypes, highlighting their potential for improved breeding strategies.
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  • The study compares outcomes of hemodynamically stable trauma patients who underwent diagnostic laparoscopy (DL) versus nontherapeutic laparotomy (NL) over four years (2017-2020).
  • Data from 3801 patients were analyzed, revealing that those who had DL experienced significantly lower odds of mortality and major complications, alongside shorter hospital stays.
  • The findings suggest that DL is a more effective and safer option for stable trauma patients, reducing the need for unnecessary exploratory surgeries.
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  • The study investigates how frailty impacts the incidence of failure to rescue (FTR) among geriatric trauma patients who experienced ground-level falls (GLFs), providing insights into care quality in trauma centers.
  • Data was analyzed from a large database (2017-2020), including 34,100 geriatric GLF patients, with frailty identified based on the 11-Factor Modified Frailty Index; FTR was measured by mortality after major complications.
  • Results showed frail patients had higher rates of major complications (3.6% vs. 2%) and FTR (1.8% vs. 0.6%), and even among those with complications, frail patients had a significantly higher mortality
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Article Synopsis
  • Most traumatic lung injuries are typically treated non-operatively, but this study focuses on understanding survival rates for patients needing surgery for lung injuries on a nationwide scale.
  • The study analyzed data from 170,377 trauma patients, revealing that only 2,159 (about 1.3%) required surgical intervention, with various types of surgery performed, including wedge resections, lobectomies, and pneumonectomies.
  • The overall mortality rate for these surgical patients was 30%, with higher rates for more extensive surgeries like pneumonectomy; predictors of mortality included hilar injuries, age, and existing head and abdominal injuries.
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Introduction: The management of injuries to the iliac artery presents a challenging clinical scenario due to the impeded anatomical access. Obesity is a common comorbid condition known to affect the outcomes of trauma patients; however, there is a paucity of data on the association of obesity with the treatment and outcomes of iliac artery injuries. The aim of this study was to assess the association between body mass index (BMI) on the management and outcomes of patients with iliac artery injuries.

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Introduction: Trauma and cancer are the leading causes of death in the US. There is a paucity of data describing the impact of cancer on trauma patients. We aimed to determine the influence of cancer on outcomes of trauma patients.

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Introduction: Management of subclavian artery injuries (SAI) and iliac artery injuries (IAI) in adolescent trauma patients poses a considerable challenge due to their complex anatomical locations. The aim of our study was to determine the association between the injury mechanism and type of repair with the outcomes of patients with traumatic SAI and IAI.

Methods: In this retrospective analysis of the American College of Surgeons Trauma Quality Improvement Program database2017-2020, adolescent (<18 y) patients with SAI and IAI undergoing either endovascular or open repair were included.

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Introduction: This study aimed to develop and validate Futility of Resuscitation Measure (FoRM) for predicting the futility of resuscitation among older adult trauma patients.

Methods: This is a retrospective analysis of the American College of Surgeons-Trauma Quality Improvement Program database (2017-2018) (derivation cohort) and American College of Surgeons level I trauma center database (2017-2022) (validation cohort). We included all severely injured (injury severity score >15) older adult (aged ≥60 y) trauma patients.

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Background: Optimal utilization of vasopressors during early post-injury resuscitation remains unclear. Our study aims to describe the relationship between the timing of vasopressor administration and outcomes among hypotensive trauma patients.

Methods: This was a retrospective analysis of the 2017-2018 ACS-TQIP database.

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Background: Malnutrition is shown to be associated with worse outcomes among surgical patients, yet its postdischarge outcomes in trauma patients are not clear. This study aimed to evaluate both index admission and postdischarge outcomes of geriatric trauma patients who are at risk of poor nutritional status.

Methods: This is a secondary analysis of the prospective observational American Association of Surgery for Trauma Frailty Multi-institutional Trial.

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Despite the critical role of balanced nutrition in crop productivity, the use of potash (K) and zinc (Zn) is not much practiced by Pakistani farmers. The reduced nutrient uptake and crop productivity together increase the costs associated with fertilization and revisit farmers' confidence in the efficacy and profitability of fertilizers. To address this problem, a field study was conducted in the research area of the MNS-University of Agriculture, Multan, in collaboration with Engro Fertilizers Limited.

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Introduction: There is a lack of data on the outcomes of thoracic damage control surgery (TDCS). This study aimed to describe the characteristics and outcomes of patients undergoing TDCS.

Methods: This is a retrospective analysis of the American College of Surgeons-Trauma Quality Improvement Program database (2017-2021).

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Background: Medicinal plant-mediated combinational therapies have gained importance globally due to minimal side effects and enhanced treatment outcomes compared to single-drug modalities. We aimed to analyze the cytotoxic potential of each conventional treatment i.e.

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Introduction: There is a paucity of data on the effect of preinjury substance (alcohol, drugs) abuse on the risk of delirium in patients with traumatic brain injury (TBI). This study aimed to assess the incidence of delirium among patients with blunt TBI in association with different substances.

Methods: We analyzed the 2020 American College of Surgeons-Trauma Quality Improvement Program.

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Purpose: To evaluate the dose-dependent effect of whole blood (WB) on the outcomes of civilian trauma patients with hemorrhagic shock. Methods: We performed a 2-year (2020-2021) retrospective analysis of the ACS-TQIP dataset. Adult (≥18) trauma patients with a shock index (SI) >1 who received at least 5 units of PRBC and one unit of WB within the first 4 h of admission were included.

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Introduction: This study aims to evaluate the temporal trends of mortality among frail versus non-frail older adult trauma patients during index hospitalization.

Methods: We performed a 3-year (2017-2019) analysis of ACS-TQIP. We included all older adult (age ≥65 years) trauma patients.

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Background: Giant cell arteritis is a critically ischaemic disease with protean manifestations that require urgent diagnosis and treatment. European Alliance of Associations for Rheumatology (EULAR) recommendations advocate ultrasonography as the first investigation for suspected giant cell arteritis. We developed a prediction tool that sequentially combines clinical assessment, as determined by the Southend Giant Cell Arteritis Probability Score (SGCAPS), with results of quantitative ultrasonography.

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Cobalt is an essential metal to maintain several functions in the human body and is present in functional materials for numerous applications. Thus, to monitor these functions, it is necessary to develop suitable probes for the detection of cobalt. Presently, researchers are focused on designing different chemosensors for the qualitative and quantitative detection of the metal ions.

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Peanuts play a pivotal role as an economic crop on a global scale, serving as a primary source of both edible oil and protein. Peanut rust ( Speg.) disease constitutes a significant global biotic stress, representing a substantial economic threat to the peanut industry by inducing noteworthy reductions in seed yields and compromising oil quality.

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