Ca3 T-Type Voltage-Gated Ca Channels and the Amyloidogenic Environment: Pathophysiology and Implications on Pharmacotherapy and Pharmacovigilance.

Voltage-gated Ca channels (VGCCs) were reported to play a crucial role in neurotransmitter release, dendritic resonance phenomena and integration, and the regulation of gene expression. In the septohippocampal system, high- and low-voltage-activated (HVA, LVA) Ca channels were shown to be involved in theta genesis, learning, and memory processes. In particular, HVA Ca2.

Spontaneous long-term and urethane induced hippocampal EEG power, activity and temperature data from mice lacking the Ca3.2 voltage-gated Ca channel.

This article provides raw relative electroencephalographic (EEG) power, temperature and activity data from controls and Ca3.2 deficient mice. Radiotransmitter implantation was carried out in male experimental mice under ketamine/xylazine narcosis.

Pharmacological Neuroenhancement: Current Aspects of Categorization, Epidemiology, Pharmacology, Drug Development, Ethics, and Future Perspectives.

Recent pharmacoepidemiologic studies suggest that pharmacological neuroenhancement (pNE) and mood enhancement are globally expanding phenomena with distinctly different regional characteristics. Sociocultural and regulatory aspects, as well as health policies, play a central role in addition to medical care and prescription practices. The users mainly display self-involved motivations related to cognitive enhancement, emotional stability, and adaptivity.

Enhanced hippocampal type II theta activity AND altered theta architecture in mice lacking the Ca3.2 T-type voltage-gated calcium channel.

T-type Ca channels are assumed to contribute to hippocampal theta oscillations. We used implantable video-EEG radiotelemetry and qPCR to unravel the role of Ca3.2 Ca channels in hippocampal theta genesis.

Functional implications of Ca 2.3 R-type voltage-gated calcium channels in the murine auditory system - novel vistas from brainstem-evoked response audiometry.

Voltage-gated Ca channels (VGCCs) are considered to play a key role in auditory perception and information processing within the murine inner ear and brainstem. In the past, Ca 1.3 L-type VGCCs gathered most attention as their ablation causes congenital deafness.

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice.

Brainstem evoked response audiometry (BERA) is of central relevance in the clinical neurophysiology. As other evoked potential (EP) techniques, such as visually evoked potentials (VEPs) or somatosensory evoked potentials (SEPs), the auditory evoked potentials (AEPs) are triggered by the repetitive presentation of identical stimuli, the electroencephalographic (EEG) response of which is subsequently averaged resulting in distinct positive (p) and negative (n) deflections. In humans, both the amplitude and the latency of individual peaks can be used to characterize alterations in synchronization and conduction velocity in the underlying neuronal circuitries.

Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca3.2 T-type voltage-gated calcium channel.

Objectives: Voltage-gated Ca channels (VGCCs) are of central relevance in regulating Ca influx into living cells. The low-voltage activated (LVA) Ca3 T-type Ca channels are widely distributed throughout the brain including the peripheral auditory system and ascending auditory tract. Their exact role in auditory information processing is still not fully understood.

Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca2.3 R-type voltage-gated calcium channel.

This data article provides raw auditory evoked brainstem responses (ABRs) from controls and Ca2.3 transgenics, i.e.