An Insight Into the Phytochemical Composition, Cardioprotective, and Antioxidant Characteristics of Small Knotweed ( R. Br.) Extract and Its Derived Fractions.

, a member of the Polygonaceae family, is commonly known as small knotweed and has been traditionally used to treat various ailments, including cough, gastrointestinal disorders, respiratory infections, liver disease, inflammation, dysentery, eczema and ringworms, and other skin conditions. Many studies have suggested that plants belonging to this genus possess strong cardio-protective potentials. Rats were pre-treated with crude methanolic extract and other fractions at a dose of 500 mg/kg followed by administration of Isoproterenol hydrochloride after 24 h for 2 days.

Evaluation of the anti-cholelithiasis activity of vinegar-soaked Ficus carica fruit in adults: A randomized controlled trial.

This study aimed to evaluate the efficacy of vinegar-soaked Ficus carica fruits (VSFCF) for managing cholelithiasis in adults. A parallel-group, single-blinded, randomized controlled trial at Noreen Nishat Welfare Hospital, Khanewal, Pakistan, was conducted from December 2023 to February 2024. Fifty adults with ultrasound-confirmed cholelithiasis were randomly assigned to receive either VSFCF (1 g/kg/day) or ursodiol (600 mg/day).

Pharmacological evaluation and binding behavior of 4,4'-diamino-2,2'-stilbene disulfonic acid with metal ions using spectroscopic techniques.

Industrial and human activities contribute significantly to the environmental contamination of heavy metal ions (HMIs), which have detrimental effects on aquatic life, plants, and animals, causing major toxicological problems. The commercially available has been playing a vital role in the detection of heavy metal ions and has significantly inhibited a variety of cancer cells in numerous field of modern science. The current investigation aimed to ensure the detection of heavy metals ions from the environment and fluorescence imaging of DSD in the treatment of cancer cells.

Phenolic phytochemistry, , , , and mechanistic anti-inflammatory and antioxidant evaluations of .

Excessive and imbalance of free radicals within the body lead to inflammation. The objective of the current research work was to explore the anti-inflammatory and antioxidant potential of the isolated compounds from In this study, the isolated phenolic compounds were investigated for and anti-inflammatory potential along with the antioxidant enzyme. The anti-inflammatory and antioxidant potential of the phenolic compounds was assayed via various enzymes like COX-1/2, 5-LOX and ABTS, DPPH, and HO free radical enzyme inhibitory assay.

The influence of environment and Earnings on Prolonged existence and human fertility: A Deeper Dive into Asia's environmentally vulnerable nations.

This study inspects the impact of environmental deterioration and income on longevity and fertility in Asian countries, specifically the nations that are highly vulnerable to extreme weather. The study examines the data, covering two decades from 2000 to 2019. The empirical conclusions of the panel ARDL-PMG and the CS-ARDL econometric models indicate that environmental degradation leads to a decline in birth rate and life expectancy, while a rising income has a significant influence over longevity.

Evaluation of phase change material-graphene nanocomposite for thermal regulation enhancement in buildings.

The growth of high-efficiency phase change material (PCM) nanocomposites with good heat conduction and substantial thermal capacity was of vital significance for practical matters in the sustainable utilization of energy. A novel leakage-proof n-heptadecane-graphene nanocomposite was prepared by a direct impregnation procedure from n-heptadacne as a PCM and nanographene as a skeleton. The creation of shape-stabilized nanocomposite was checked with X-ray diffraction (XRD), Raman, and Fourier transform infrared (FTIR) spectroscopy.

Biochar supported metallo-inorganic nanocomposite: A green approach for decontamination of heavy metals from water.

Heavy metal contamination of water has become a global environmental burden, which has stirred up agitation worldwide. Fabrication of adsorbents utilizing either low cost, environment friendly materials or waste products can be helpful in remediating environmental pollution. The current study evolved around the synthesis of nanocomposites derived from such raw precursors like spent tea waste biochar, hydroxyapatite, and clays.

sp. Extracted Lipids Prevent Alopecia by Enhancing Antioxidation and Inhibiting Ferroptosis of Dermal Papilla Cells.

Alopecia has gradually become a problem that puzzles an increasing number of people. Dermal papilla cells (DPCs) play an important role in hair follicle (HF) growth; thus, exploring the effective chemicals or natural extracts that can remediate the growth of DPCs is vital. Our results showed that sp.

Design of high gain base station antenna array for mm-wave cellular communication systems.

Millimeter wave (mm-Wave) wireless communication systems require high gain antennas to overcome path loss effects and thereby enhance system coverage. This paper presents the design and analysis of an antenna array for high gain performance of future mm-wave 5G communication systems. The proposed antenna is based on planar microstrip technology and fabricated on 0.

Garlic and ginger essential oil-based neomycin nano-emulsions as effective and accelerated treatment for skin wounds' healing and inflammation: and studies.

Skin, largest organ of human, is directly exposed to environment and hence is prone to high rates of injuries and microbial infections. Over the passage of time these microbes have developed resistance to antibiotics making them ineffective especially in lower doses and hence, higher dosages or new drugs are required. The current study deals with designing of nano-emulsion (NE) formulations composed of garlic and ginger oils (0.

End-to-End Deep Convolutional Recurrent Models for Noise Robust Waveform Speech Enhancement.

Because of their simple design structure, end-to-end deep learning (E2E-DL) models have gained a lot of attention for speech enhancement. A number of DL models have achieved excellent results in eliminating the background noise and enhancing the quality as well as the intelligibility of noisy speech. Designing resource-efficient and compact models during real-time processing is still a key challenge.

Biosurfactants and chemotaxis interplay in microbial consortium-based hydrocarbons degradation.

Hydrocarbons are routinely detected at low concentrations, despite the degrading metabolic potential of ubiquitous microorganisms. The potential drivers of hydrocarbons persistence are lower bioavailability and mass transfer limitation. Recently, bioremediation strategies have developed rapidly, but still, the solution is not resilient.

Antioxidant, antinociceptive, anti-inflammatory, and hepatoprotective activities of pentacyclic triterpenes isolated from Edgew.

Edgew is in folk use in Pakistan as an analgesic, anti-inflammatory, and liver ailments. Therefore, we have investigated antioxidant, antinociceptive, anti-inflammatory, and hepatoprotective activities of the isolated compounds (ceanothic acid and zizybrenalic acid) from the chloroform fraction of . Ceanothic acid and zizybrenalic acid showed significant DPPH and HO scavenging activity as compared to control.

Site-Specific Biofunctionalization of Cellulose and Poly(dimethylsiloxane): A Chemoenzymatic Approach for Surface Engineering.

Site-specific, covalent immobilization of protein is of great importance in the design of bioanalytical devices. User-defined covalent coupling of protein onto the surface has been primarily limited to a noncanonical amino acid or cysteine residues. It is desirable to develop a new approach for site-specific biofunctionalization.

Fungi from the extremes of life: an untapped treasure for bioactive compounds.

More than 80% of the Earth surface is consisted of hostile and harsh environments, classified as extreme from an anthropogenic perspective. Microorganisms with acclimatized nature dominate these extreme ecosystems of the biosphere. Survivals in such environments initiate an inductive force leading to the production of noteworthy metabolites having peculiar biochemistry.

Construction of a hydrocarbon-degrading consortium and characterization of two new lipopeptides biosurfactants.

Apparent solubility and bioavailability of hydrophobic compounds are the major problems in the bioremediation process, which could be overcome by the bacteria capable of biosurfactant production and concurrent hydrocarbon degradation. In this work, we constructed an artificial bacterial consortium containing Lysinibacillus, Paenibacillus, Gordonia and Cupriavidus spp. from glyceryl tributyrate enriched bacteria collected from the non-contaminated site.

Microscopic investigations and pharmacognostic techniques used for the standardization of leaf of Rhus succedanea var. Himalaica J. D. Hook.

Rhus succedanea is generally traded, distributed, and sold in the markets in its crude and raw form. This may have been mixed with adulterants, mismanaged by malpractices, and substituted with other closely related drugs having different effect. This study is therefore carried out to authenticate the plant through pharmacognostic evaluations including morphological microscopic and physio-chemical features.

Evaluation of Paeonia emodi for its cardioprotective potentials: An investigative study towards possible mechanism.

Ethnopharmacological Relevance: Paeonia emodi Wall. ex Royle (peony) is an important member of family Paeoniaceae. Different parts of the plant have been folklorically used for treatment of different diseases.

Evaluation of Paeonia emodi and its gold nanoparticles for cardioprotective and antihyperlipidemic potentials.

Paeonia emodi Wall. ex Royle is an important member of family Paeoniaceae and folklorically used for constipation, hysteria, respiratory diseases, epilepsy and cardiac diseases like hypertension, palpitations, congestive heart failure and atherosclerosis. In the present study, ethyl acetate fraction of P.

Pharmacognostic and phytochemical studies of Zanthoxylum armatum DC.

The pharmacognostic and phytochemical investigations on the leaf, stem bark, and fruit of Zanthoxylum armatum were carried out. Macroscopic study of leaf, stem bark, and fruit of Z. armatum revealed some of the characteristic features like size, shape, color, odor and taste of the crude drug.

PHARMACOGNOSTIC EVALUATION OF THE LEAF OF VAR. HIMALAICA. J. D HOOKER.

Background: is generally traded, distributed and sold in the markets in its crude and raw form. This may have been mixed with adulterants, mismanaged by malpractices and substituted with other closely related drugs having different effect. This study is therefore carried out to authenticate the plant through pharmacogonostic evaluations.

Short Communication: Pharmacognostic and Pharmacological evaluation of Ruellia tuberosa L.

Ruellia tuberosa Linn. of family Acanthaceae was studied to investigate the microscopical, vein islet and vein termination numbers, palisade ratio, stomatal index and different chemical parameters. The antibacterial, antifungal and phytotoxic activities of the crude extract of the plant were also determined.

In vivo antinociceptive and muscle relaxant activity of leaf and bark of Buddleja asiatica L.

The current study was designed to assess the antinociceptive and skeleton muscle relaxant effect of leaves and barks of Buddleja asiatica in animal models. In acetic acid induced writhing test, pretreatment of ethanolic extract of leaves and barks evoked marked dose dependent antinociceptive effect with maximum of 70% and 67% pain relief at 300mg/kg i.p.