and studies on clinically important enzymes inhibitory activities of flavonoids isolated from .

The genus is known to contain diterpenoids, and several isolated compounds which exhibited biological activities including significant multidrug resistance reversal effects. This work is focused on the isolation, and studies of two natural bio-active flavonoids ( & ) isolated from bark for the very first time. The phytochemical investigation resulted in the identification of two flavonoids: 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-chromen-4-one and 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4H-chromen-4-one , which were isolated for the first time from .

Potent leishmanicidal and antibacterial metabolites from .

Inspired from the leishmanicidal and antibacterial potential of the fractions obtained from the crude extract of stem, the anti-leishmanial ethyl acetate fraction was subjected to chromatographic separation, leading to the isolation of a new compound ferruginan () and a known compound (+)- cycloolivil (). The structures of and were determined by various spectroscopic techniques and were assayed for their antibacterial and leishmanicidal potential. Compound showed 75% inhibition after 24 h of incubation and 98% inhibition after 48 h of incubation against KWH23 promastigotes at 100 μg/mL concentration, while compound exhibited 73% and 96% inhibition at the same concentration and incubation time.