Publications by authors named "Muhammad Haris Raza Farhan"
Advances in Artificially Designed Antibacterial Active Antimicrobial Peptides.
Biotechnol Bioeng
February 2025
Article Synopsis
- * Despite their potential, AMPs face challenges like low effectiveness, instability, and toxicity that make clinical use difficult.
- * Researchers are focusing on artificially designing and optimizing AMPs to overcome these challenges, with the review discussing advancements and strategies for creating new, effective antibacterial peptides.
Article Synopsis
- - Bacterial vaccines are essential for preventing infectious diseases and lowering death rates in affected groups, showcasing their critical role in public health.
- - Innovations like reverse vaccinology and bioinformatics are transforming vaccine design, particularly with the advancement of multi-epitope vaccines (MEVs) that target specific pathogens.
- - The review highlights the methods used in epitope vaccine development, recent advancements, and the challenges faced in creating genetically engineered multi-epitope vaccines for future applications.
Transfer dynamics of antimicrobial resistance among gram-negative bacteria.
Sci Total Environ
December 2024
Antimicrobial resistance (AMR) in gram-negative bacteria (GNBs) is a significant global health concern, exacerbated by mobile genetic elements (MGEs). This review examines the transfer of antibiotic resistance genes (ARGs) within and between different species of GNB facilitated by MGEs, focusing on the roles of plasmids and phages. The impact of non-antibiotic chemicals, environmental factors affecting ARG transfer frequency, and underlying molecular mechanisms of bacterial resistance evolution are also discussed.
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