Neurokinin B Administration Induces Dose Dependent Proliferation of Seminal Vesicles in Adult Rats.

Background: Neurokinin B; an endogenous decapeptide, mediates its reproductive physiological actions through gonadotropin releasing hormone. Despite the potential role of Neurokinin B on seminal vesicles, its effects on seminal vesicles in adult male mammals remain elusive. We aimed to investigate the potentials of variable doses of Neurokinin B, its agonist and antagonist on histomorphology and expression of NK3R on seminal vesicles, and secretory activity of seminal vesicles in adult male rats.

Dose-Dependent Degeneration of Leydig Cells Following Kisspeptin-10 Administration: An Ultrastructural Study.

Background: The discovery of kisspeptin signaling as a key regulator of gonadotropin- releasing hormone (GnRH) secretion from the hypothalamus enhanced our understanding of the neuroendocrine regulation of mammalian reproduction. Effects of central and peripheral administration of kisspeptin on plasma gonadotropins, testosterone, and spermatogenesis are studied in detail.

Objective: The present study was conducted to check the ultrastructure of Leydig cells in prepubertal male rats in response to the administration of a range of kisspeptin doses.

To Evaluate and Compare Changes in Baseline Strength of Hairs after Treating them with Deionized Water and Hard Water and its Role in Hair Breakage.

Background And Aim: Interaction of hair with water is common. This study was conducted to compare changes in baseline strength of hair after treating it with hard water and deionized water.

Material And Methods: Hardness level of water samples collected from 10 districts of KP, Pakistan was determined, and that with maximum hardness was considered our sample hard water.

Effect of topical application of hard water in weakening of hair in men.

Background: Hard water is thought to play a key role in weakening of hair (not Hair Loss) and breakage especially when travelling is involved. In our community, commonly men do the travelling and complain more about hair problem which is why only young male individuals were included in this study.

Materials And Methods: Water samples from different districts of KPK, Pakistan, were collected and their hardness values were estimated to find the water sample of maximum and minimum water hardness in order to know the maximum hardness hair would encounter in KPK, Pakistan.

Human semen quality and sperm DNA damage assessed by comet assay in clinical groups.

Background/aim: About 10%-15% of couples around the world suffer from infertility. Male infertility is responsible directly or indirectly in approximately 60% of cases. A deficiency in semen is the most common cause of male infertility.

Insight into the serum kisspeptin levels in infertile males.

Background: Regulation of reproduction is now considered to be carried out by the kisspeptin and its receptor, GPR54 or Kiss1r. Mutations of either Kiss1 or Kiss1r in humans and mice result in profound hypogonadotropic hypogonadism. The present study was aimed to determine whether the levels of kisspeptin are associated with male infertility.

The effect of chronic kisspeptin administration on seminal fructose levels in male mice.

The discovery that kisspeptin was critical for normal fertility in all mammalian species including humans, ushered in a new chapter in our understanding of the control of GnRH secretion. Kisspeptin, the product of the KISS1 gene, plays an essential role in the regulation of spermatogenesis acting primarily at the hypothalamic level of the gonadotropic axis. Among the many identified substances in human semen, fructose is becoming increasingly significant.

Kisspeptin-10 induces dose dependent degeneration in prepubertal rat prostate gland.

Background: Kisspeptin peptides mediate their actions through the GnRH loop system. How kisspeptins affect prostate gland in prepubertal male mammals remains elusive.

Methods: To address this kisspeptin was administered as subchronic (12 days) twice daily i.

Immature rat seminal vesicles show histomorphological and ultrastructural alterations following treatment with kisspeptin-10.

Background: Degenerative effects of critical regulators of reproduction, the kisspeptin peptides, on cellular aspects of sexually immature male gonads are known but similar information on accessory sex glands remain elusive.

Methods: Prepubertal laboratory rats were injected kisspeptin-10 at three different dosage concentrations (10 pg, 1 ng and 1 microgram) for a period of continuous 12 days at the rate of two doses per day. Control rats were maintained in parallel.

Metabolic syndrome in school children of Dera Ismail Khan, Pakistan.

Background: Childhood obesity has increased considerably in many regions of the world including Pakistan. The recent phenomenon of 'nutritional transition' with a westernisation of food so prevalent in developing countries, has caused a significant rise in obesity among population that were unaware of this problem in the recent past. The aim of this study was to find out the frequency of metabolic syndrome and cardiovascular risk factors in obese school children (6-11 years) in Dera Ismail Khan.