Publications by authors named "Muhammad Fareed Khalid"
Vacuoles, E1 syndrome, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a chronic inflammatory disorder that affects various organ systems. It is associated with hematologic malignancies and is generally refractory to therapies. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be considered for selected patients.
View Article and Find Full Text PDFThis systematic review aimed to evaluate the proportion of primary and secondary endpoints in hematopoietic stem cell transplant (HSCT) phase III randomized clinical trials (RCTs) and analyze their trends in time and study sponsorship status. The Chi-square test and logistic regression analyses were performed using SPSS version 28. A total of 147 HSCT phase III RCTs from 2006 to 2021 reported 197 primary and 600 secondary endpoints.
View Article and Find Full Text PDFArticle Synopsis
- - The study examines geographical and racial disparities in access to CAR-T and bispecific antibodies clinical trials for DLBCL, focusing on data from ClinicalTrials.gov and the 2020 US Census.
- - Out of 75 trials identified, 85% were US-based, primarily funded by pharmaceutical companies, with a concentration of trials in southern and midwestern states, and many states having no trials at all.
- - Significant racial disparities were found, as only 33% of African Americans lived in counties with trial access, with a majority of trial locations situated in predominantly White areas, emphasizing the need for strategies to improve equity in clinical trial access.