Radiosynthesis and Preclinical Evaluation of [Tc]Tc-Tigecycline Radiopharmaceutical to Diagnose Bacterial Infections.

Background/objectives: As a primary source of mortality and disability, bacterial infections continue to develop a severe threat to humanity. Nuclear medicine imaging (NMI) is known for its promising potential to diagnose deep-seated bacterial infections. This work aims to develop a new technetium-99m (Tc) labeled tigecycline radiopharmaceutical as an infection imaging agent.

Ectopic Intrathoracic Kidney due to Diaphragmatic Eventration Detected on Bone Scan.

The technetium-99m methylene diphosphonate (Tc-MDP) whole-body bone scan along with single-photon emission computed tomography (SPECT/CT) can detect challenging soft tissue uptake patterns. We present a case of a 67-year-old female in whom the Tc-MDP scan, performed 3 hours after injection, revealed abnormal soft tissue uptake in the right thoracic region. No functioning right kidney was seen in the right lumbar region.

Antimicrobial peptides as infection imaging agents: better than radiolabeled antibiotics.

Nuclear medicine imaging techniques offer whole body imaging for localization of number and site of infective foci inspite of limitation of spatial resolution. The innate human immune system contains a large member of important elements including antimicrobial peptides to combat any form of infection. However, development of antibiotics against bacteria progressed rapidly and gained popularity over antimicrobial peptides but even powerful antimicrobials failed to reduce morbidity and mortality due to emergence of mutant strains of bacteria resulting in antimicrobial resistance.

Hypospermatogenesis and spermatozoa maturation arrest in rats induced by mobile phone radiation.

Objective: To determine the morphological changes induced by mobile phone radiation in the testis of Wistar albino rats.

Study Design: Cohort study.

Place And Duration Of Study: Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, from April 2007 to June 2008.

Multifocal adamantinoma simulating traumatic pathology on bone scanning.

This is a case report of a young physically active patient who presented with pain in the right leg. Plain radiograph and bone scan showed lesions mimicking stress fracture. Follow-up investigations (repeated plain radiography and three phase bone scan) and histopathological examination proved it as a case of multifocal adamantinoma.

Bilateral condensing osteitis of clavicles: differential diagnosis of an unusual case.

Condensing osteitis of the clavicle (COC) is a rare disease characterized by sclerosis of the medial end of the clavicle. Brower was the first to coin this term in 1974. Since then many cases have been published in medical journals.

Medical image registration: basic science and clinical implications.

Image Registration is a process of aligning two or more images so that corresponding feature can be related objectively. Integration of corresponding and complementary information from various images has become an important area of computation in medical imaging. Merging different images of the same patient taken by different modalities or acquired at different times is quite useful in interpreting lower resolution functional images, such as those provided by nuclear medicine, in determining spatial relationships of structures seen in different modalities.

An imaging analysis of (99m)Tc-UBI (29-41) uptake in S. aureus infected thighs of rabbits on ciprofloxacin treatment.

Purpose: The uptake of (99m)Tc-UBI (29-41) was evaluated at sites of bacterial infections in rabbits before and after treatment with ciprofloxacin.

Methods: Staphylococcus aureus susceptible to ciprofloxacin was used to induce a focal infection in each rabbit of group 1 (G1), group 2 (G2), and group 3 (G3) with 2 x 10(4), 2 x 10(6), and 2 x 10(8) colony forming units (CFU), respectively. After 24 h, images of infected thighs (target: T) and contralateral thighs (nontarget: NT) were acquired.

Detection of bilateral, multifocal breast cancer and assessment of tumour response to neoadjuvant chemotherapy by Tc-99m sestamibi imaging - a case report.

In breast cancer, neoadjuvant chemotherapy needs early indication for responsiveness. Tc-99m sestamibi scintimammography provides comprehensive information about the extent of disease including multiple foci in one or both breasts and possible involvement of nodes. In the present case, X-mammography was positive for a suspicious mass in the upper quadrant of the left breast only.

Gated spect myocardial perfusion scintigraphy for identifying septal perfusion artifacts in left bundle branch block.

Objective: To determine the role of gated Single Photon Emission Computed Tomography (SPECT) for accurate assessment of myocardial perfusion scintigraphy (MPS) of patients with left bundle branch block (LBBB).

Design: Analytical study.

Place And Duration Of Study: Punjab Institute of Nuclear Medicine (PINUM), Faisalabad, Pakistan, from June 2002 to April 2003.

Antimicrobial peptide 99mTc-ubiquicidin 29-41 as human infection-imaging agent: clinical trial.

Unlabelled: Ubiquicidin (UBI) 29-41 is a cationic, synthetic antimicrobial peptide fragment that binds preferentially with the anionic microbial cell membrane at the site of infection. The current study was conducted to evaluate its potential as an infection-imaging agent in humans.

Methods: Eighteen patients, 9 female and 9 male (mean age, 31.

99mTc-labeled antimicrobial peptide ubiquicidin (29-41) accumulates less in Escherichia coli infection than in Staphlococcus aureus infection.

Unlabelled: 99mTc-Labeled antimicrobial peptide ubiquicidin, (99m)Tc-UBI (29-41) in a freeze-dried kit, was evaluated as a bacterial infection-seeking agent in Staphlococcus aureus- and Escherichia coli-induced infections.

Methods: Thirty-three rabbits were classified in 3 groups. Biodistribution of (99m)Tc-UBI (29-41) was studied in 3 animals (group I).

Diagnosis of coronary artery disease by stress echocardiography and perfusion scintigraphy.

This meta-analysis was performed to compare the diagnostic efficacy of stress echocardiography (SE) and Stress perfusion studies (SPS) in detecting coronary artery disease (CAD). A meta-analysis of peer reviewed articles, published in English language, reporting head-to-head comparison of vasodilator stress echocardiography (VSE) and SPS for the diagnosis of CAD, was performed. Data of 13 studies comprising of 860 patients from 13 different institutions were analyzed.

Standardization of the techniques evaluating endothelial functions.

Assessment of endothelial functions is an important area of medical research. Endothelial functions provide vital information for the management of coronary artery disease (CAD). As a measurable parameter, endothelial functions give a prognostic index that integrates the overall stress imposed by coronary risk factors.

Clinical value of left atrial appendage flow for prediction of long-term sinus rhythm maintenance in patients with nonvalvular atrial fibrillation.

Objectives: This study evaluated the role of various clinical and echocardiographic parameters, including the left atrial appendage (LAA) anterograde flow velocity, for prediction of the long-term preservation of sinus rhythm (SR) in patients with successful cardioversion (CV) of nonvalvular atrial fibrillation (AF).

Background: Echocardiographic parameters for assessing long-term SR maintenance after successful CV of nonvalvular AF are not accurately defined.

Methods: Clinical, transthoracic echocardiographic and transesophageal echocardiographic (TEE) data--measured in AF lasting >48 h--of 186 consecutive patients (116 men, mean age: 65 +/- 9 years) with successful CV (electrical or pharmacologic) were analyzed for assessment of one-year maintenance of SR.