Pomegranate Peel Extract as 6-Phosphogluconate Dehydrogenase (6PGD) Inhibitor for Treatment of Breast Cancer.

Targeting the enzymes of Pentose Phosphate Pathway (PPP) has been emerged as a novel strategy for treatment of cancer. 6-phosphogluconate dehydrogenase (6PGD) is third enzyme of PPP and converts 6-phosphogluconate (6-PG) into ribulose 5-phosphate (R-5-P) and produces NADPH. The overexpression of 6PGD has been reported in many human cancers especially in breast cancer and is emerged as the potential anti-cancer drug target.

Efficacy and toxicity of different plant extracts over the period of time in (Say) (Hymenoptera: Braconidae).

(Say) is an important parasitoid and played a suitable model role for bio control programs. Pest management through biocontrol approaches such as plant extracts is an ecologically responsive and enthusiastic means of reducing insect pests. The main objective of the present research was to discover the efficiency and susceptibility periods of plant extracts for the assessment of parasitoids.

Evaluating the Compatibility of Spinosad and Alpha-Cypermethrin for Controlling Six Insect Pests Infesting Stored Wheat.

The deterioration of stored wheat due to pest infestations is a significant concern, with pests like , , , , , and being major contributors. This study examined the efficacy of spinosad and alpha-cypermethrin, individually and in combination, against these pests under laboratory conditions. Spinosad was tested at two concentrations (0.

Two are better than one: the combinations of Beauveria bassiana, diatomaceous earth, and indoxacarb as effective wheat protectants.

The current study evaluates the efficacy of the entomopathogenic fungus Beauveria bassiana (Balsamo-Crivelli) Vuillemin (Hypocreales: Cordycipitaceae), diatomaceous earth (DE) (Protect-It), and the oxadiazine indoxacarb, at single or combined applications on wheat kernels, for the management of the rusty grain beetle, Cryptolestes ferrugineus (Stephens) (Coleoptera: Laemophloeidae), the red flour beetle, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae), the khapra beetle, Trogoderma granarium Everts (Coleoptera: Dermestidae), and the lesser grain borer, Rhyzopertha dominica (F.) (Coleoptera: Bostrychidae). The study was conducted between November 2020 and August 2021 in Faisalabad under a complete randomized block design.

Exploration of polyacrylamide microplastics and evaluation of their toxicity on multiple parameters of .

Due to the increased production of polyacrylamide microplastics in the environment impacting the adverse effects on aquatic organisms have become a global concern. The present study aimed to evaluate the toxicity of different concentrations (0.018, 0.

extract ameliorates carbon tetrachloride induced hepatotoxicity in rat model.

Major objective of this study was to explore the protective effect of the methanolic extract of  against carbon tetrachloride induced hepatotoxicity in rats. has locally been used for multiple medicinal proposes. Methanolic extract of (whole plant) was prepared with Soxhlet extractor and rotatory evaporator.

A Review on Phyto-pharmacology of Oxalis corniculata.

Oxalis corniculata (Oxalidaceae) is a small decumbent and delicate appearing medicinal herb flourishing in warm temperate and tropical domains such as Pakistan and India. Main bioactive chemical constituents of Oxalis plant include several alkaloids, flavonoids, terpenoids, cardiac glycosides, saponins, and phlobatannins, along with steroids. Due to its polyphenolic, glycosides and flavonoid profile, it is proved to be protective in numerous ailments and exhibit various biological activities such as anti-fungal, anti-cancer, anti-oxidant, antibacterial, anti-diabetic, and cardioprotective.

Effect of gibberellic acid and titanium dioxide nanoparticles on growth, antioxidant defense system and mineral nutrient uptake in wheat.

Nanoparticles (NPs), as a novel source of industrial materials, have been extensively used in recent years which ultimately ends up in soils and may cause toxic effects on plants. Gibberellic acid (GA), phytohormone, has ability to minimize abiotic stresses in plants. The role of GA in minimizing titanium dioxide (TiO) NPs stress in plants is still unknown.

Extracts as Novel PKM2 Inhibitors for Treatment of Triple Negative Breast Cancer.

Pyruvate kinase (PK), a key enzyme that determines glycolytic activity, has been known to support the metabolic phenotype of tumor cells, and specific pyruvate kinase isoform M2 (PKM2) has been reported to fulfill divergent biosynthetic and energetic requirements of cancerous cells. PKM2 is overexpressed in several cancer types and is an emerging drug target for cancer during recent years. Therefore, this study was carried out to identify PKM2 inhibitors from natural products for cancer treatment.

Radioprotective Role of Natural Polyphenols: From Sources to Mechanisms.

The identification and development of radioprotective agents have emerged as a subject matter of research during recent years due to the growing usage of ionizing radiation in different areas of human life. Previous work on synthetic radioprotectors has achieved limited progress because of the numerous issues associated with toxicity. Compounds extracted from plants have the potential to serve as lead candidates for developing ideal radioprotectors due to their low cost, safety, and selectivity.

Combined use of different nanoparticles effectively decreased cadmium (Cd) concentration in grains of wheat grown in a field contaminated with Cd.

Cadmium (Cd) accumulation in arable lands has become a serious matter for food security. Among various approaches, the application of nanoparticles (NPs) for remediation of contaminated water and soils is attaining more popularity worldwide. The current field experiment was executed to explore the impacts of single and combined use of ZnO NPs, Fe NPs and Si NPs on wheat growth and Cd intake by plants in a Cd-contaminated field.

Synthesis and characterization of hydroxyethyl cellulose copolymer modified polyurethane bionanocomposites.

Bio based polyurethane nanocomposites (renewable thermosets) show a diverse range in properties, processing components and production of smart materials for health, food, and energy sectors. In this work, polyurethane nanocomposites based on isophorone diisocyanate (IPDI), and hydroxyl terminated-polybutadiene (HTPB) incorporating clay were modified using hydroxyethyl cellulose (HLAC) to be further assessed for thermal and mechanical properties. Elastomers samples were prepared by blending clay suspension and PU prepolymer to attain clay contents of 0.

Foliar exposure of zinc oxide nanoparticles improved the growth of wheat (Triticum aestivum L.) and decreased cadmium concentration in grains under simultaneous Cd and water deficient stress.

A pot study was conducted to explore the effectiveness of zinc oxide nanoparticles (ZnO NPs) foliar exposure on growth and development of wheat, zinc (Zn) and cadmium (Cd) uptake in Cd-contaminated soil under various moisture conditions. Four different levels (0, 25, 50, 100 mg/L) of these NPs were foliar-applied at different time periods during the growth of wheat. Two soil moisture regimes (70% and 35% of water holding capacity) were maintained from 6 weeks of germination till plant harvesting.

Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities.

Nature has provided prodigious reservoirs of pharmacologically active compounds for drug development since times. Physcion and physcion 8-O-β-D-glucopyranoside (PG) are bioactive natural anthraquinones which exert anti-inflammatory and anticancer properties with minimum or no adverse effects. Moreover, physcion also exhibits anti-microbial and hepatoprotective properties, while PG is known to have anti-sepsis as well as ameliorative activities against dementia.

6-Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells: From cancer initiation to metastasis and chemoresistance.

Reprogrammed metabolism is key biochemical characteristic of malignant cells, which represents one of the emerging hallmarks of cancer. Currently, there is rising contemplation on oxidative pentose phosphate pathway (PPP) enzymes as potential therapeutic hits due to their affiliation with tumor metabolism. 6-Phosphogluconate dehydrogenase (6PGD), third oxidative decarboxylase of PPP, has received a great deal of attention during recent years due to its critical role in tumorigenesis and redox homeostasis.

Skin sebum and skin elasticity: Major influencing factors for facial pores.

Objective: The current research work was initiated to develop anti-aging phytocosmetic formulation of phytoantioxidant, to evaluate their effect on human skin, and to link R parameters of skin with skin sebum and aging.

Methods: According to COLIPA, 10 healthy male volunteers, aged between 20 and 30 years, having no skin infection or other hypersensitivity disorders, were included in the study. The effect of formulation was evaluated on skin pores and skin elasticity on cheeks for 90 days at regular interval.

Plant derived anticancer agents: A green approach towards skin cancers.

Plants have been used as medicinal agents since the origin of mankind. High cost and severe side effects associated with conventional chemotherapy has limited their general acceptability and fuel up the search for alternate options. The alternative treatment options like phytochemicals have come up with ease of availability and cost effectiveness.