Anti-tumour activity and toxicological studies of combination treatment of and gemcitabine on pancreatic xenograft model.

Background: Pancreatic cancer is the most aggressive cancer type. Gemcitabine is the first line chemo-drug used for pancreatic cancer but exerts a broad spectrum of organ toxicities and adverse effects in patients.

Aim: To evaluate the anti-tumour activity and toxicological effects of extract formulation (ID: C5EOSEW5050ESA trademarked as Nuva-static), and gemcitabine combination on pancreatic xenograft model.

2D Nanoarchitectures for Sensing/Biosensing Applications.

Schematic illustration of 2D materials based sensors for the detection of various analytes.

Spontaneous intra-electron transfer within rGO@FeO-MnO catalyst promotes long-term NO reduction at ambient conditions.

Iron (Fe)-based catalysts are widely used for taming nitrogen oxides (NO) containing flue gas, but the regeneration and long-term reusability remains a concern. The reusability can be acquired by external additives, and resultantly can not only increase the cost but can also add to process complexity as well as secondary pollutants. Herein, a self-sustainable material is designed to regenerate the catalyst for long-term reusability without adding to process complexity.

Deciphering SARS CoV-2-associated pathways from RNA sequencing data of COVID-19-infected A549 cells and potential therapeutics using in silico methods.

Background: Coronavirus (CoV) disease (COVID-19) identified in Wuhan, China, in 2019, is mainly characterized by atypical pneumonia and severe acute respiratory syndrome (SARS) and is caused by SARS CoV-2, which belongs to the Coronaviridae family. Determining the underlying disease mechanisms is central to the identification and development of COVID-19-specific drugs for effective treatment and prevention of human-to-human transmission, disease complications, and deaths.

Methods: Here, next-generation RNA sequencing (RNA Seq) data were obtained using Illumina Next Seq 500 from SARS CoV-infected A549 cells and mock-treated A549 cells from the Gene Expression Omnibus (GEO) (GSE147507), and quality control (QC) was assessed before RNA Seq analysis using CLC Genomics Workbench 20.

Dose Dependent Effects of Against the Paraquat Induced Parkinsonism like Symptoms in Animals' Model: , and Mechanistic Studies.

The aims and objectives of the study were to evaluate the antiParkinson's (PD) potential of (BCE). (Poir.) Müll.

Automatic computer science domain multiple-choice questions generation based on informative sentences.

Students require continuous feedback for effective learning. Multiple choice questions (MCQs) are extensively used among various assessment methods to provide such feedback. However, manual MCQ generation is a tedious task that requires significant effort, time, and domain knowledge.

Anti-Inflammatory and Anti-Angiogenic Aattributes of Lam. and its Nanoclay-Based Pectin-Sericin films.

Inflammation is a strong reaction of the non-specific natural immune system that helps to start protective responses against encroaching pathogens and develop typical immunity against intruding factors. However, prolonged inflammation may lead to chronic autoimmune diseases. For thousands of years, medicinal plants have served as an excellent source of treatment for chronic pathologies such as metabolic diseases.

Global impact and contributing factors in varicose vein disease development.

Varicose veins are convoluted, expanded, and stretched subcutaneous veins of the lower leg and are the most frequently reported medical condition. This condition has a higher prevalence in Western and developed countries. Inadequacy of the valves results in reflux of blood in the veins of the lower leg.

Research Trends in the Use of Polyaniline Membrane for Water Treatment Applications: A Scientometric Analysis.

Polyaniline (PANI), which is a member of the family of electrically conducting polymers, has been widely discussed as a potential membrane for wastewater treatment. Although a steady growth in PANI literature was observed, analyzing PANI literature quantitatively is still a novelty. The main aim of this study is to unearth the current research status, global trends, and evolution of PANI membranes literature and their use in water treatment applications over time.

Dental age estimation of Malaysian Indian children and adolescents: applicability of Chaillet and Demirjian's modified method using artificial neural network.

Background: Recognising the importance of dental age (DA) estimation in forensic investigations, a variety of methods abound in the literature due to population-specific attributes. A reference eight-tooth method developed by Chaillet and Demirjian estimated the DA of children and adolescents.

Aim: This study aims to investigate the applicability of Chaillet and Demirjian's method among Malaysian Indians aged 5.

COVID Academic Pandemic: Techno Stress Faced by Teaching Staff for Online Academic Activities.

This paper analyzes the impact of the COVID-19 pandemic on the mental health of the teachers, specifically the techno stress arising in them as a result of issues faced by them in the use of technology when they conduct the online academic activities. It aims to assess the major factors related to the online teaching that specifically adds to techno stress on the teachers during the COVID-19 outbreak. Finally, the study aims to provide suggestions to the policymakers and the management of the universities so that the effect of the COVID-19's on teachers' mental health and the related techno stress can be reduced.

Controlling air pollution by lowering methane emissions, conserving natural resources, and slowing urbanization in a panel of selected Asian economies.

The destruction of the earth's ecosystems is the most pressing issue globally. Carbon emissions account for nearly half of global air pollution. Methane is the primary source of ground-level ozone and a significant source of greenhouse gases (GHGs), with greater warming potential than carbon dioxide emissions.

Polycystic Ovary Syndrome: A Disorder of Reproductive Age, Its Pathogenesis, and a Discussion on the Emerging Role of Herbal Remedies.

Polycystic ovary syndrome (PCOS) is a very common, complex, and heterogeneous endocrine disorder of women that involves a combination of environmental and genetic factors. PCOS affects women of growing age particularly at the early to late reproductive stage (15-35 years). Currently, PCOS affects 1 in every 10 women worldwide.

Therapeutic Potential of Standardized Extract of (L.) All. and Its Phytochemicals against Skin Cancer in Animal Model: , , and Studies.

(L.) All. is known to have anti-inflammatory and anticancer properties.

Nanostructured Lipid Carrier-Based Delivery of Pioglitazone for Treatment of Type 2 Diabetes.

Pioglitazone (PGZ) is utilized as a therapeutic agent in the management of (type 2) diabetes to control blood glucose levels. The existing research work was intended to make and optimize PGZ-containing NLCs (nanostructured lipid carriers). The fabricated nanostructured lipid carrier preparation was optimized by using different concentrations of the surfactants (Tween 80 and Span 80) and solid lipid (Compritol 888 ATO) and liquid lipid (Labrasol) while keeping the concentration of drug (PGZ), and co-surfactants (poloxamer 188) the same.

Low-Stress and Optimum Design of Boost Converter for Renewable Energy Systems.

This paper examines the design and analysis of DC-DC converters for high-power and low-voltage applications such as renewable energy sources (RESs) and comparisons between converters based on switch stresses and efficiency. The RESs including photovoltaic arrays and fuel cell stacks must have enhanced output voltages, such as 380 V DC in the case of a full bridge inverter or 760 V DC in the case of a half bridge inverter, in order to interface with the 220 V AC grid-connected power system. One of the primary difficulties in developing renewable energy systems is enhancing DC-DC converters' efficiency to enable high step-up voltage conversion with high efficiency and low voltage stress.

Frequency of Hepatitis B, C, and Human Immunodeficiency Virus in Blood Donors.

Introduction: Blood donation is considered an important source of infection transmitted through transfusion, especially in developing countries like Pakistan.

Objective: To find out the frequency of seroprevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) among blood donors in the blood bank.

Methods: A prospective cohort study was carried out on blood donors at the National Institute of Blood Disease and Bone Marrow Transplant, Karachi, during the period of January 1, 2019 to December 31, 2020.

Engineering MOFs derived metal oxide nanohybrids: Towards electrochemical sensing of catechol in tea samples.

In this work, we have successfully developed Cu-MOF/CuO/NiO nanocomposites (NCs) and employed as a novel electrochemical sensing platform in catechol (CC) detection. The Scanning electron microscopy (SEM) along Energy dispersive X-ray Analysis (EDX), Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) are carried out to characterize the as-fabricated Cu-MOF/CuO/NiO NCs. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques have used to obtain oxidation peak currents of CC.

Characterization of Corn Oil Using Fluorescence Spectroscopy.

In these studies, Fluorescence spectroscopy has been utilized for the characterization of pure and commercially available corn oil. The best excitation wavelength of 380 nm has been investigated, where maximum spectral information can be assessed. The emission spectra from pure and commercial corn oil samples disclosed that pure corn oil contained oleic acid, beta-carotenes, chlorophylls, isomers of vitamin E and traces of oxidized products which exhibit fluorescence at 406, 525, 675, 440 and 435/475 nm respectively.