Detection of small-sized DNA fragments in a glassy nanopore by utilization of CRISPR-Cas12a as a converter system.

The fabrication of nanopores with a matched pore size, and the existence of multiple interferents make the reproducible detection of small-sized molecules by means of solid-state nanopores still challenging. A useful method to solve these problems is based on the detection of large DNA nanostructures related to the existence of small-sized targets. In particular, a DNA tetrahedron with a well-defined 3D nanostructure is the ideal candidate for use as a signal transducer.

Experimental and theoretical study for CO activation and chemical fixation with epoxides.

The synthesis of five-membered cyclic carbonates catalytic cycloaddition reaction of CO with epoxides is considered to be an effective technology for alleviation of the energy crisis and global warming. Various commercial organic bases and ionic salts were used as catalysts, while the relationship of catalytic activity and compound structure has been seldom explored. Herein, a facilely obtained binary catalytic system based on triethylamine/NBuBr was developed for CO activation and chemical fixation.

Nanohybrid of Carbon Quantum Dots/Molybdenum Phosphide Nanoparticle for Efficient Electrochemical Hydrogen Evolution in Alkaline Medium.

The exploration of highly efficient non-noble metal electrocatalysts for hydrogen evolution reaction (HER) under alkaline conditions is highly imperative but still remains a great challenge. In this work, the nanohybrid of carbon quantum dots and molybdenum phosphide nanoparticle (CQDs/MoP) has been firstly demonstrated as an efficient alkaline HER electrocatalyst. The CQDs/MoP nanohybrid is readily prepared through a charge-directed self-assembly of CQDs with phosphomolybdic acid (HPMoO) at the molecular level, followed by facile phosphatizing at 700 °C.

Total synthesis, structural, and biological evaluation of stylissatin A and related analogs.

The natural product cyclic peptide stylissatin A (1a) was reported to inhibit nitric oxide production in LPS-stimulated murine macrophage RAW 264.7 cells. In the current study, solid-phase total synthesis of stylissatin A was performed by using a safety-catch linker and yielded the peptide with a trans-Phe(7) -Pro(6) linkage, whereas the natural product is the cis rotamer at this position as evidenced by a marked difference in NMR chemical shifts.