Antimicrobial resistance modulation of MDR E. coli by antibiotic coated ZnO nanoparticles.

We evaluated three types of total six preparations against multidrug resistant E. coli i) three antibiotic coated ZnO nanoparticles (gentamicin coated nanoparticle-GNp; chloramphenicol coated nanoparticles-CNp; and both gentamicin & chloramphenicol coated nanoparticle-GCNp), ii) ZnO nanoparticle alone-Np, and iii) two antibiotics used in single (Gentamicin-G; and Chloramphenicol-C). A total of n = 200 sub-clinically positive mastitic milk samples of bovine origin were processed for isolation of MDR E.

Acute Management of Iatrogenic Injury to Vertebral Artery With Central Venous Catheter in a Critically Ill Patient.

Vertebral artery (VA) injury during catheterization is quite rare given its anatomical position, but can be catastrophic when it is not discovered early on and managed accordingly. A multidisciplinary approach to the management of such injury has to weigh-in the benefits and risks of open surgery versus endovascular intervention. This can be done after thorough assessment of the patient's condition and accessibility of the injured vessel.

Efficacy and safety of recently approved drugs for sickle cell disease: a review of clinical trials.

Sickle cell disease is prevalent in several parts of the world. Most hospitalizations of these patients are related to pain crisis episodes. Moreover, levels of hemoglobin are lower in sickle cell disease patients as compared with the general population.

Inhibition of glucose assimilation in by light.

Background: The yield of microalgae biomass is the key to affect the accumulation of fatty acids. A few microalgae can assimilate organic carbon to improve biomass yield. In mixotrophic cultivation, microalgae can use organic carbon source and light energy simultaneously.

Gastroenteritis and Miliary Lung Opacities: An Interesting Combination of Findings.

A 19-year-old man with a one-year history of vaping with multiple emergency room visits for acute gastroenteritis like symptoms was noted to have asymptomatic hypoxia with a PaO2 of 65 mmHg. Computed tomography revealed bilateral nodular lung infiltrates. History was negative for travel, allergies, or animal exposure.

Skin Disease Classification using Neural Network.

Background: In this study, a novel and fully automatic skin disease classification approach is proposed using statistical feature extraction and Artificial Neural Network (ANN) based classification using first and second order statistical moments, the entropy of different color channels and texture-based features.

Aims: The basic aim of our study is to develop an automated system for skin disease classification that can help a general physician to automatically detect the lesion and classify it to disease types.

Method: The performance of the proposed approach is corroborated by extensive experiments performed on a dataset of 588 images containing 6907 lesion regions.

CAR T Cell Therapy in Pancreaticobiliary Cancers: a Focused Review of Clinical Data.

Objective: CAR T cell therapy is an innovative approach to treat cancers in the modern era. It utilizes the application of chimeric antigen receptors targeted against specific antigens expressed by the tumor cells. Although its efficacy is established in hematological malignancies, the safety and efficacy of this therapy in solid tumors, especially pancreaticobiliary cancers, is a highly investigated aspect.

Heterogeneous Pd/C-catalyzed, ligand free Suzuki-Miyaura coupling reaction furnishes new -terphenyl derivatives.

A series of new -terphenyls derivatives have been efficiently synthesized by a ligand-free heterogeneous Pd/C-catalyzed two-fold Suzuki-Miyaura coupling reaction. Methyl 5-bromo-2-iodobenzoate was selected to react with a variety of different aryl boronic acids (). Nine new -terphenyl derivatives (-) were prepared and the structures were confirmed by several analytical techniques including infrared, spectroscopy, H and C NMR spectroscopy, mass spectrometry, and in the case of compound by X-ray diffraction method.

Isolation of Oxyberberine and -Sitosterol from Royle Root Bark Extract and Cytotoxicity against Liver and Lung Cancer Cell Lines.

Royle has been traditionally used to cure rheumatism, eye and ear diseases, malarial fever, diabetes, stomach disorders, and skin diseases. There is a least amount of data available on cytotoxic capacity of from Pakistani origin, so on this basis, the present study was aimed to screen root bark extracts for cytotoxicity against cancer cell lines and isolation of chemical constituents from the most cytotoxic extract. Initial screening of extracts was performed on HepG2 cells at 100 g/mL for 72 hours of treatment by using an MTT assay.

Intellectual capital and the efficiency of SMEs in the transition economy China; Do financial resources strengthen the routes?

Intellectual capital has been grabbed the attention of researchers due to its momentous role in sustainable competitive advantage and organizational success. There is a growing catalog of related assessments, publications and reviews that display the direct and indirect role of intellectual capital in business success and profitability. Despite the bourgeoning literature, studies have not yet unleashed the influence of each dimension of intellectual capital; human capital, structural capital and customer capital on SMEs' efficiency with financial resources as a moderator.

A highly green approach towards aromatic nitro group substitutions: catalyst free reactions of nitroimidazoles with carbon nucleophiles in water.

We have successfully developed a flexible green aqueous approach for the formation of a carbon-carbon bond by the reaction of highly-enolizable carbanions (mostly derived from 1,3-dicarbonyl compounds) with an aromatic carbon bearing a nitro group. The key step involves a nucleophilic displacement reaction. All newly synthesized compounds were unambiguously characterized various spectroscopic techniques including NMR, mass spectrometry and single-crystal X-ray diffraction as applicable.

Cobalt Single-Atom Catalysts with High Stability for Selective Dehydrogenation of Formic Acid.

Metal-organic framework (MOF)-derived Co-N-C catalysts with isolated single cobalt atoms have been synthesized and compared with cobalt nanoparticles for formic acid dehydrogenation. The atomically dispersed Co-N-C catalyst achieves superior activity, better acid resistance, and improved long-term stability compared with nanoparticles synthesized by a similar route. High-angle annular dark-field-scanning transmission electron microscopy, X-ray photoelectron spectroscopy, electron paramagnetic resonance, and X-ray absorption fine structure characterizations reveal the formation of Co N centers as active sites.

Phenotypic and Genotypic Comparison of a Live-Attenuated Genotype I Japanese Encephalitis Virus SD12-F120 Strain with Its Virulent Parental SD12 Strain.

The phenotypic and genotypic characteristics of a live-attenuated genotype I (GI) strain (SD12-F120) of Japanese encephalitis virus (JEV) were compared with its virulent parental SD12 strain to gain an insight into the genetic changes acquired during the attenuation process. SD12-F120 formed smaller plaque on BHK-21 cells and showed reduced replication in mouse brains compared with SD12. Mice inoculated with SD12-F120 via either intraperitoneal or intracerebral route showed no clinical symptoms, indicating a highly attenuated phenotype in terms of both neuroinvasiveness and neurovirulence.

Complexes of N- and O-Donor Ligands as Potential Urease Inhibitors.

We report five new transition-metal complexes that inhibit the urease enzyme. Barbituric acid (), thiobarbituric acid (), isoniazid (), and nicotinamide () ligands were employed in complexation reactions. The resulting complexes were characterized using a variety of analytical techniques including infra-red and UV-vis spectroscopy, H NMR spectroscopy, elemental analysis, and single-crystal X-ray diffraction analysis.

UHPLC-MS phytochemical profiling, biological propensities and studies of roots: a medicinal herb with multifunctional properties.

The biological, chemical, and properties of methanol and dichloromethane (DCM) extracts of roots with respect to the antioxidant, enzyme inhibition, and phytochemical composition were evaluated. Total bioactive contents were determined spectrophotometrically, and the individual secondary metabolites composition was assessed ultra-high-performance liquid chromatography mass spectrometry (UHPLC-MS) analysis. Antioxidant capacities were evaluated using a panoply of assays (2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging, ferric reducing antioxidant power (FRAP), cupric reducing antioxidant power (CUPRAC), phosphomolybdenum total antioxidant capacity (TAC), and metal chelating activity (MCA)).

A State-of-the-Art Heterogeneous Catalyst for Efficient and General Nitrile Hydrogenation.

Cobalt-doped hybrid materials consisting of metal oxides and carbon derived from chitin were prepared, characterized and tested for industrially relevant nitrile hydrogenations. The optimal catalyst supported onto MgO showed, after pyrolysis at 700 °C, magnesium oxide nanocubes decorated with carbon-enveloped Co nanoparticles. This special structure allows for the selective hydrogenation of diverse and demanding nitriles to the corresponding primary amines under mild conditions (e.

Modalities for conversion of waste to energy - Challenges and perspectives.

The United Nation is achieving its sustainable development objectives by focusing on the greener technologies for waste to energy (WTE) conversion. This necessitates the exploration of every conceivable sustainable route in different sectors. Among these, sustainable bio-economy, electricity, and waste management are the most dynamic areas.

Dilute magnetic ions mediated magneto-dielectric, optical and ferroelectric response of MgAlOspinels.

Magnesium aluminate (MgAlO) commonly termed as spinel has been a subject of intense research due to its excellent thermal, optical and dielectric characteristics. These properties in such compounds can efficiently be tuned by introducing small contents of different transition metals. In this work, dilute contents of transition metals (Mn, Fe, Co, and Ni) are incorporated in MgAlOto produce the dilute magnetic compositions of these aluminates.

Root cause analysis of pre-microscopic errors in anatomical pathology using Eindhoven classification.

Objective: To evaluate pre-microscopic errors in anatomical pathology.

Methods: The cross-sectional descriptive study was conducted at the Department of Pathology of a tertiary care hospital in Lahore, Pakistan, from September, 2016, to January, 2017, and comprised surgical pathology specimens. Errors were noted across the pre-microscopic process.

Cranial CT scan evaluation of morphological variations and location of pterion in Pakistani male population for lateral neurosurgical approach.

Objective: To determine the morphological variations and location of pterion in Pakistani male population.

Methods: This retrospective observational study was carried out in the Department of Radiology, Shifa International Hospital from December 2018 to June 2019. The sample size was calculated by Open Epi web-based calculator.

β2 Integrin Gene (ITGB2) mutation spectra in Pakistani families with leukocyte adhesion deficiency type 1 (LAD1).

Leukocyte adhesion deficiency I (LADI) is an autosomal recessive type of primary immunodeficiency characterized by occurrence of repeated bacterial infections, impaired pus formation and wound healing. Genetic variations in the β-2 integrin subunit encoding gene ITGB2 have been implicated in causing the disorder. In the present study, we have investigated twelve patients presenting LAD1 features.

Environmental concerns and switching toward electric vehicles: geographic and institutional perspectives.

Smog pollution deteriorates environmental quality and has severe health risks. This affects the daily lives of people in China, particularly in urban areas. Along with other factors, a large portion for smog comes from transportations, making it dense and more hazardous in urban areas.