Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex.

Higher mammals are able to simultaneously learn and perform a wide array of complex behaviors, which raises questions about how the neural representations of multiple tasks coexist within the same neural network. Do neurons play invariant roles across different tasks? Alternatively, do the same neurons play different roles in different tasks? To address these questions, we examined neuronal activity in the posterior medial prefrontal cortex of primates while they were performing two versions of arm-reaching tasks that required the selection of multiple behavioral tactics (i.e.

Neuronal Representations of Tactic-Based Sensorimotor Transformations in the Primate Medial Prefrontal, Presupplementary, and Supplementary Motor Areas: A Comparative Study.

Adaptive context-dependent behaviors necessitate the flexible selection of multiple behavioral tactics, i.e., internal protocols for selecting an action.