Risk factors for corneal graft rejection after penetrating keratoplasty for keratoconus.

Purpose: To evaluate the association between donor-related factors and the risk of rejection in patients undergoing penetrating keratoplasty (PKP) for keratoconus.

Methods: A retrospective review was performed of keratoconus patients with no corneal neovascularization who underwent PKP from November 2014 to December 2016 and completed at least two years of follow-up. Preoperative, donor, operative, and postoperative data were collected and analyzed to identify factors leading to corneal graft rejection.

Successful Collagen Crosslinking in a Patient With Keratoconus and Systemic Scleroderma.

Scleroderma is an autoimmune disease that affects connective tissue. Keratoconus (KC) is a rare ocular condition that may appear alongside scleroderma. Contact lenses are an essential visual aid for KC patients, especially in advanced cases.

Gentian violet (GV) ink associated reaction in a case of preloaded Descemet membrane endothelial keratoplasty: Case report.

Purpose: This report describes a case of Descemet membrane endothelial keratoplasty (DMEK) graft failure after non-clearing bullae over the area of the orientation mark on the graft.

Methods: Case report.

Results: The summary of the clinical presentation and workup is described, followed by a brief overview of the DMEK procedure and the gentian violet (GV) ink used to ensure the correct orientation of the DMEK graft.

Dry Eye Disease in the Middle East and Northern Africa: A Position Paper on the Current State and Unmet Needs.

In the Middle East and Northern Africa (MENA), dry eye disease (DED) is often misdiagnosed or overlooked. This review summarizes a series of conversations with ophthalmologists in the region around a variety of climatic, lifestyle, and iatrogenic factors that contribute to specific features of DED in the MENA region. These considerations are further classified by patient lifestyle and surgical choices.

Quantile-based assessment of energy-CO2 emission nexus in Pakistan.

Nonrenewable energy sources maintain a substantial majority of Pakistan's energy composition, exceeding 70%, posing challenges to achieving sustainability goals for a low-carbon economy. Recognizing this, the study determines the critical thresholds where renewable and nonrenewable energies affect more significantly on CO2 emission over the period from 1972Q1 to 2020Q4. The analysis begins by confirming the stationarity of the data through quantile unit root analysis, followed by an examination of long-term associations using quantile cointegration.

Clinical use of cryopreserved ultra-thick human amniotic membrane for anophthalmic socket contracture.

Purpose: To study the use of ultra-thick human amniotic membrane for management anophthalmic socket contracture.

Methods: A prospective study done at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Thirty-six patients (45 eyelids) were involved.

Splinter Cataract in Patients with Keratoconus and Frequent Eye Rubbing: A Novel Finding.

BACKGROUND Patients with keratoconus are at increased risk of developing cataract at a younger age compared to the normal population. Predisposing factors include atopy and topical steroid use. In this case series we report the novel observation of splinter-shaped cortical cataract in 16 eyes of 14 patients with keratoconus in the absence of other risk factors of cataract development from a single center in Riyadh, Saudi Arabia.

Penetrating Keratoplasty Versus Descemet Stripping Automated Endothelial Keratoplasty in Children With Congenital Hereditary Endothelial Dystrophy: Long-Term Results.

Purpose: The purpose of this study was to compare the outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PKP) in patients with congenital hereditary endothelial dystrophy (CHED).

Methods: This was a retrospective, comparative study of all the patients with a histopathological diagnosis of CHED who underwent PKP or DSAEK between January 1, 1990, and December 31, 2016. All the cases were included except those patients who had clear grafts but did not complete 2 years of postoperative follow-up.

Impact of shadow economy on renewable and nonrenewable energy consumption in Pakistan: evidence from quantile cointegration and causality analysis.

The objective of this study is to identify the impact of the shadow economy on renewable and nonrenewable energy consumption at aggregated and disaggregated levels over the period of 1972Q1-2018Q4 in Pakistan. This study carries nonlinear/asymmetric time series analysis such as quantile unit root test for stationary of data series, newly developed quantile cointegration (Xiao, J. Econom.

Outcomes and complications of implantable collamer lens for mild to advance keratoconus.

Purpose: To evaluate the outcome and safety of implantable collamer lens (ICL; (Visian, STAAR Surgical, Monrovia, CA, USA) in mild to advance keratoconus patients with myopia and myopic astigmatism.

Methods: This retrospective study evaluated all patients who underwent ICL implantation for the management of keratoconus at a tertiary care eye hospital from January 2012 to January 2018. The mean duration of follow-up was 15.

The Iris Thickness in a Healthy Saudi Population.

Purpose Iris thickness (IT), a known risk factor for angle closure glaucoma, has not been evaluated in the normal Saudi population. Methods Quantitative information on IT was evaluated in healthy Saudi eyes using anterior segment optical coherence tomography (ASOCT). IT and iris volume was measured with the room 'light on' (LON) and 'light off' (LOFF) using Image J software.

Effect of Bandage Contact Lens Exchange on Pain and Healing After Photorefractive Keratectomy-A Randomized Control Trial.

Objective: To evaluate the corneal re-epithelialization and patient-perceived pain after bandage contact lens (BCL) exchange on day one, after photorefractive keratectomy (PRK).

Methods: A randomized controlled trial, of all patients who underwent bilateral transepithelial-PRK (trans-PRK) or bilateral alcohol debridement and PRK (A-PRK), between March and October 2019. One eye of each patient was randomly assigned to BCL exchange on the first postoperative day (exchange group) and the BCL was not exchanged in the fellow eye (control group).

Long term keratits treatment with topical cyclosporin a in autoimmune polyglandular syndrome type 1.

Purpose: To report long term results of two cases treated with topical cyclosporin A 1% for keratitis associated with autoimmune polyglandular syndrome (APS1).

Observations: A 25-year-old male and a 17-year-old female were referred from endocrinology as APS1-related autoimmune keratitis. Extended-duration treatment with topical cyclosporin A (CsA) 1% was used for 24 and 18 months, respectively.

Incidence and outcome of transplantation of fungal-culture-positive donor corneoscleral tissue in optical keratoplasty.

Purpose: This study aims to determine the incidence of fungal-culture-positive corneoscleral donor rim in patients undergoing keratoplasty and evaluate clinical outcomes of eyes that received these contaminated donor tissues.

Methods: Patients who had optical keratoplasty between 2006 and 2016 and were found to have fungal-culture-positive donor rim were included. Microbiological and eye bank records were reviewed to determine the incidence of positive fungal rim cultures.

Thermal, Physico-Chemical, and Mechanical Behaviour of Mass Concrete with Hybrid Blends of Bentonite and Fly Ash.

Mass concrete has been commonly known for its thermal stresses which arise due to the entrapment of hydration temperature susceptible to thermal cracking. The utilization of mineral additives is a promising and widely adopted technique to mitigate such effects. This paper presents the thermal, physico-chemical, mechanical, and morphological behaviour of mass concrete with blends of bentonite (BT) and fly ash (FA).

Intraocular lens opacification after descemet stripping automated endothelial keratoplasty.

Purpose: Intraocular lens (IOL) opacification is a rare but serious complication that may necessitate its exchange. The use of intraocular gases is a known precipitant. Descemet stripping endothelial keratoplasty (DSAEK) involves injecting air into the anterior chamber.

Randomized Controlled Study of Ocular Lubrication Versus Bandage Contact Lens in the Primary Treatment of Recurrent Corneal Erosion Syndrome.

Purpose: To investigate the efficacy of bandage contact lenses (BCLs) in comparison with that of ocular lubricants (OLs) in the initial management of recurrent corneal erosion syndrome.

Methods: A randomized controlled trial of 29 patients with recurrent corneal erosion syndrome presenting to the ophthalmology departments of the Oxford Eye Hospital and the Royal Berkshire Hospital, United Kingdom. The patients were randomized to wear either BCLs (for a 3-month duration, replaced every 30 days) or use OLs (4 times a day, with Lacri-Lube ointment at night for 3 months).

Association between heat shock protein 70/Hom genetic polymorphisms and uveitis in patients with sarcoidosis.

Purpose: The predisposition to sarcoidosis, a systemic granulomatous disorder of unknown etiology, is genetically determined, and genetics appears also to drive the disease down distinct phenotypic pathways. This study was undertaken to test the hypothesis that sarcoidosis-related uveitis represents a genetically distinct disease subset, by investigating single nucleotide polymorphisms (SNPs) in the HSP-70/1 and HSP-70/Hom genes. HSP70 molecules play a key role in the immune response by functioning both as chaperones and as inducers of proinflammatory cytokine secretion.

Polymorphisms of chemokine and chemokine receptor genes in idiopathic immune-mediated posterior segment uveitis.

Purpose: Chemokines are important inflammatory mediators that play a crucial role in uveitis. Polymorphisms in chemokine genes can alter the expression of these genes in the inflammatory cells, which, in turn, can affect the clinical phenotype of the disease. The purpose of this study was to identify polymorphisms in chemokine genes that can predict visual outcome in patients with immune-mediated posterior segment uveitis.

Chemokine gene polymorphisms in idiopathic anterior uveitis.

Objectives: The aim of this study was to determine whether there are any associations between single nucleotide polymorphisms of the chemokine genes IL-8, MCP-1, their corresponding receptors CXCR1 and CCR2 and disease outcome in patients with acute idiopathic anterior uveitis.

Methods: 60 Caucasian patients with idiopathic acute recurrent anterior uveitis together with 120 healthy Caucasian control subjects were tested for the presence of 16 bi-allelic polymorphisms and HLA-B27 using polymerase chain reaction in association with sequence-specific primers with mismatches at the 3' end. The genetic data was then compared between patients and controls, and within the patient group itself for association with clinical disease outcome.

The prevalence of pseudoexfoliation syndrome in Pakistan. Hospital based study.

Background: Pseudoexfoliation syndrome (PXS) is the most common identifiable cause of secondary glaucoma, the prevalence of which varies considerably among different ethnicities. The aim of this study was to assess the prevalence of pseudoexfoliation syndrome in Pakistan.

Methods: A prospective study conducted in the period from January 2003 to June 2004 in a teaching hospital serving a population of about 7.