This study examines the association between serum Sestrin2 (SESN2) levels and cardiovascular disease (CVD) risk factors in healthy and diabetic adults, using data from the Qatar Biobank (QBB). A total of 844 participants were included, with 518 in the diabetic cohort and 326 in the healthy cohort. Clinical characteristics, cardiometabolic markers, and SESN2 levels were measured, and binomial logistic regression analyses were conducted to assess the associations between SESN2 and various health indices.
View Article and Find Full Text PDFThe RAF1-RAP1A interaction activates the MAPK/ERK pathway which is very crucial in the carcinogenesis process. This protein complex influences tumor formation, proliferation, and metastasis. Understanding aberrant interactions driven by clinical mutations is vital for targeted therapies.
View Article and Find Full Text PDFOcular myasthenia gravis (OMG) is a neuromuscular disease characterized by the production of autoantibodies against post-synaptic proteins at the neuromuscular junction (NMJ). An 18-year-old male who had symptoms of drooping eyelids and double vision was diagnosed with ocular myasthenia gravis on investigations and examinations. Treatment was initiated with a tablet of pyridostigmine 60 mg twice daily per oral for two weeks, followed by three times daily for four weeks.
View Article and Find Full Text PDFBackground: MicroRNAs (miRNAs) participate in diverse cellular changes following acute ischemic stroke (AIS). Circulating miRNAs, stabilized and delivered to target cells via extracellular vesicles (EVs), are potential biomarkers to facilitate diagnosis, prognosis, and therapeutic modulation. We aimed to identify distinctive expression patterns of circulating EV-miRNAs in AIS patients.
View Article and Find Full Text PDFBackground Since bilateral nasal packing entails nasal and airway obstruction, this practice consequently leads to oral breathing. The resulting hypoxemia may then negatively impact vital signs, including blood pressure (BP), blood oxygen saturation (SpO2), and heart rate (HR). These systemic effects have a detrimental effect on patients.
View Article and Find Full Text PDFObjective The objective of this study was to compare K1, K2, Kmax, and pachymetry values from Pentacam and Galilei scans of corneal topography in order to assess their correlation and interchangeability in clinical practice. Methodology A total of 34 patients (68 eyes) were enrolled in the study. Corneal topography was performed using Pentacam and Galilei devices on the same day.
View Article and Find Full Text PDFPotato is the third most important food crop, but cultivation is challenged by numerous diseases and adverse abiotic conditions. To combat diseases, frequent fungicide application is common. Knocking out susceptibility genes by genome editing could be a durable option to increase resistance.
View Article and Find Full Text PDFContinued climate change impose multiple stressors on crops, including pathogens, salt, and drought, severely impacting agricultural productivity. Innovative solutions are necessary to develop resilient crops. Here, using quantitative potato proteomics, we identify Parakletos, a thylakoid protein that contributes to disease susceptibility.
View Article and Find Full Text PDFThis study conducted in the Kyungpook National University Eco-friendly Agriculture Research Centre between 2022 and 2023 investigates the environmental implications of fence-type solar photovoltaic (PV) systems in diverse agricultural settings. Despite the increasing adoption of solar energy for climate change mitigation, there is a noticeable gap in research regarding the potential environmental impact of these specific PV systems. Focusing on heavy metal concentrations, including Cadmium (Cd), Copper (Cu), Arsenic (As), Mercury (Hg), Lead (Pb), Hexavalent Chromium (Cr), Zinc (Zn), and Nickel (Ni), across distinct fields, the study reveals significant fluctuations.
View Article and Find Full Text PDFLeucine is the native known ligand of Sestrin2 (Sesn2) and its interaction with Sesn2 is particularly important, as it influences the activity of mTOR in aging and its associated pathologies. It is important to find out how leucine interacts with Sesn2 and how mutations in the binding pocket of leucine affect the binding of leucine. Therefore, this study was committed to investigating the impact of non-synonymous mutations by incorporating a broad spectrum of simulation techniques, from molecular dynamics to free energy calculations.
View Article and Find Full Text PDFThis narrative review examines the role of vitamin D as a biomarker in ear disorders, including benign paroxysmal positional vertigo (BPPV), otitis media, bell's palsy, Meniere's disease, and hearing loss. PubMed, The Cochrane Library, and Google Scholar were utilized to conduct a comprehensive literature search, and findings were combined from studies from 2014 to 2024. As highlighted in this review, there is a consistent association between vitamin D deficiency and an increased risk and recurrence of disease especially in BPPV and otitis media.
View Article and Find Full Text PDFIntroduction: Diabetes mellitus (DM) is recognized as one of the oldest chronic diseases and has become a significant public health issue, necessitating innovative therapeutic strategies to enhance patient outcomes. Traditional treatments have provided limited success, highlighting the need for novel approaches in managing this complex disease.
Methods: In our study, we employed graph signature-based methodologies in conjunction with molecular simulation and free energy calculations.
Introduction Tracheostomy, although a common surgical procedure, is associated with potential complications. Complications can be avoided with accurate technique and proper operative and postoperative care. A surgeon should know the complications of the procedure and how to avoid them so that complications may be prevented or minimized.
View Article and Find Full Text PDFCornea plana (CP) is a rare ocular condition existing in two distinct clinical and hereditary forms: a milder, autosomal dominant type I and a more severe, autosomal recessive type II. The condition is more commonly found in Finnish, Saudi, and Czech families. We report three brothers from a consanguineous marriage that presented with complaints of decreased vision of varying degrees.
View Article and Find Full Text PDFPurtscher retinopathy (PR) is an occlusive vasculopathy of the retinal microvasculature that classically presents 24-48 hours after compressive chest trauma. Symptoms vary from mild to severe acute visual loss. Characteristic findings on fundus examination such as Purtscher flecken, cotton wool spots, and retinal hemorrhages may also be found.
View Article and Find Full Text PDFMicrospherophakia is a rare congenital anomaly characterized by an abnormally small and spherical crystalline lens, which can be associated with several systemic syndromes. We present an extremely rare case of bilateral anteriorly displaced microspherophakia in a female child with Marfanoid habitus. The patient displayed phenotypic features resembling Marfan syndrome, including tall stature, muscle hypotonia, dolichostenomelia, and increased arm span than body length.
View Article and Find Full Text PDFIEEE Trans Serv Comput
September 2021
The emergence of cloud and edge computing has enabled rapid development and deployment of Internet-centric distributed applications. There are many platforms and tools that can facilitate users to develop distributed business process (BP) applications by composing relevant service components in a plug and play manner. However, there is no guarantee that a BP application developed in this way is fault-free.
View Article and Find Full Text PDFThis article summarises common oral lesions that clinicians may face in everyday practice by categorising them by clinical presentation: ulcerated lesions, white or mixed white-red lesions, lumps and bumps, and pigmented lesions. The pathologies covered include recurrent aphthous stomatitis, herpes simplex virus, oral squamous cell carcinoma, geographic tongue, oral candidosis, oral lichen planus, pre-malignant disorders, pyogenic granuloma, mucocele and squamous cell papilloma, oral melanoma, hairy tongue and amalgam tattoo. The objective of this review is to improve clinician knowledge and confidence in assessing and managing common oral lesions presenting in the primary care setting.
View Article and Find Full Text PDFIntroduction Standard automated perimetry (SAP) is the gold standard of visual field assessment in patients with neuro-ophthalmic conditions. Glaucoma is a progressive optic neuropathy characterized by damage to the ganglion cell complex with corresponding visual field defects and intraocular pressure (IOP) being the only modifiable ocular risk factor. Recent advances in technology have paved the way for remote screening and monitoring of visual field defects with the aid of a computer or tablet-based software.
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