Publications by authors named "Muhammad A Shamim"
Cardiovascular-kidney-metabolic (CKM) syndrome is the association between obesity, diabetes, CKD (chronic kidney disease), and cardiovascular disease. GDF-15 mainly acts through the GFRAL (Glial cell line-derived neurotrophic factor Family Receptor Alpha-Like) receptor. GDF-15 and GDFRAL complex act mainly through RET co-receptors, further activating Ras and phosphatidylinositol-3-kinase (PI3K)/Akt pathways through downstream signaling.
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- The study focuses on infrazygomatic miniscrew implants (IZC-MSI) as temporary anchorage devices in orthodontics, highlighting their importance in supporting maxillary tooth movement.
- The systematic review aimed to evaluate the success rate and stability factors of IZC-MSI through a comprehensive electronic search of multiple databases.
- Results from 14 studies indicated a 92% overall success rate for these implants, with variations based on sample size and significant heterogeneity in factors influencing their stability.
Diphtheria is a reemerging vaccine-preventable infection of public health concern. Pooled estimates of serum IgG anti-diphtheria antibody levels can assist in estimating the susceptible population. The objective was to estimate pooled estimate of protective IgG anti-diphtheria antibodies in population globally.
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- India's commitment to the "Leave No One Behind" principle of the Sustainable Development Goals highlights the urgent need for data on the oral health of children with intellectual and developmental disabilities (IDD), leading to a systematic review of existing literature.
- The review included 15 studies after searching extensive databases, revealing that while 91% of IDD children regularly use toothbrushes, a significant 38% still have poor oral hygiene and 64% suffer from dental caries.
- The study concludes that existing oral health practices are inadequate and calls for tailored health programs to better meet the specific needs of children with IDD in India.
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- This systematic review and meta-analysis aimed to explore the link between H. pylori found in dental plaque and gastric H. pylori infection.
- After analyzing data from 27 studies involving 2408 participants, results indicated a significant association with an odds ratio of 3.80, suggesting higher gastric infections in those with H. pylori in dental plaque.
- The findings highlight the potential role of dental plaque as a reservoir for H. pylori, which could impact strategies for managing gastric infections, despite the overall evidence certainty being low.
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- A literature review assessed maternal and fetal outcomes related to aplastic anemia (AA) during pregnancy, shedding light on the rarity of scientific evidence in this area.
- Seven studies were included, covering a total of 248 pregnancies, to investigate various complications, including the prevalence of preeclampsia and other pregnancy-related issues.
- The review reported a 13% prevalence of preeclampsia among AA pregnancies and evaluated additional outcomes such as spontaneous abortion and premature rupture of membranes, providing crucial insights for patients and healthcare providers.
: Several randomized controlled trials (RCTs) have shown conflicting results on cortisol levels following probiotic administration in healthy and diseased populations. Previous analyses were inconclusive due to limited studies, and evidence is lacking on how these effects vary by health status; region; therapy duration; medications, and use of single or multiple strains. : In this systematic review and meta-analysis (PROSPERO [CRD42024538539]), we searched PubMed, Cochrane Library, Embase, Scopus, Web of Science, CINAHL, ProQuest, and Web of Science Preprints until 13 August 2024, for RCTs on probiotic administration, either alone or combined, across all age groups and without specific medical condition requirements.
View Article and Find Full Text PDFColorectal cancer (CRC) is a growing public health problem. Several clinical studies have shown a potentially oncogenic role of copper in CRC progression, but the reports are inconsistent. To examine published evidence on the association between tissue copper status and CRC, we carried out a systematic review and meta-analysis, searching Cochrane Library, EBSCOhost, Embase, ProQuest, PubMed/Medline, Scopus, and Web of Science for studies reporting colon tumor and matched non-cancerous tissue copper concentrations in CRC patients for articles published till June 2023.
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- Heart failure affects around 64 million people, particularly with HFrEF, which lacks direct trial comparisons between leading treatments like ARNI and SGLT2 inhibitors.
- The study recruits 100 HFrEF patients and aims to compare the effects of dapagliflozin and sacubitril/valsartan over 16 weeks, focusing on biomarkers and cost-effectiveness.
- The findings are intended to guide clinicians on treatment decisions while exploring how these medications influence GDF-15 levels for better prognostic understanding.
Background: Although the recent literature indicates that mpox (monkeypox) primarily affects men, there are also multiple reports in women. Estimates of the sex distribution of mpox patients and patterns will enable a better understanding of the ongoing mpox outbreak.
Methods: In this systematic review and meta-analysis, seven databases were searched for studies published in English up to January 4, 2023.
HIV self-testing (HIVST) plays a significant role in addressing the health care needs of high-risk populations, particularly men who have sex with men (MSM). The present systematic review and meta-analysis provide an assessment of the prevalence of HIVST among MSM within the last 5 years. Seven databases (PubMed, Web of Science, Cochrane, Scopus, EMBASE, ProQuest, and EBSCOhost) were searched systematically from January 1, 2018 to March 10, 2023.
View Article and Find Full Text PDFBackground: Mpox infection is a zoonotic illness that resembles smallpox. Vaccination is widely regarded as a vital effective method of preventing mpox, however, there is lack of consensus of effectiveness of a single dose of mpox vaccine in the current 2022-2023 outbreak. We pooled data from real-world studies to evaluate the efficacy of the JYNNEOS vaccination given as a single dosage.
View Article and Find Full Text PDFImportance: Currently, 30-50 % of individuals with depression and 40 % with anxiety-collectively referred to as common mental disorders (CMDs), exhibit inadequate responses to antidepressant treatments.
Objective: To assess the effectiveness and safety of drug-metabolizing enzyme pharmacogenetic variation informed treatment (PGxIT) versus usual antidepressant treatment (UT) in patients with CMDs.
Data Sources: A literature search was conducted in the MEDLINE, Scopus, and Cochrane Library databases from inception until January 30, 2024.
Background: Cerebral palsy (CP) is a neurological disorder that impairs motor abilities. Identifying maternal biomarker derangements can facilitate further evaluation for early diagnosis, potentially leading to improved clinical outcomes. This study investigates the association between maternal biomarker derangements and CP development during the antenatal period.
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- Maternal and child health in remote communities is often at risk due to limited healthcare access, leading to reliance on traditional birth attendants (TBAs) and raising questions about integrating traditional and modern practices.
- A systematic review and meta-analysis of six studies found that training TBAs significantly reduced perinatal and neonatal mortality rates, though results for stillbirth rates were inconclusive.
- Although there is some evidence supporting TBA training benefits, the studies reviewed had methodological issues, indicating a need for further well-designed research to refine training interventions and improve outcomes.
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- The systematic review analyzes menstrual cup adoption among reproductive-age women in India, highlighting limited knowledge and low usage rates.
- Only 35% of women have knowledge about menstrual cups, and just 5% currently utilize them, though 62% of non-users express willingness to try in the future.
- Key barriers include leakage concerns and cost, suggesting a need for increased education and initiatives to make menstrual cups more affordable and accessible.
Background And Aims: Goal-directed fluid therapy (GDFT) has conflicting evidence regarding outcomes in neurosurgical patients. This meta-analysis aimed to compare the effect of GDFT and conventional fluid therapy on various perioperative outcomes in patients undergoing neurosurgical procedures.
Methods: A comprehensive literature search was conducted using PubMed, EMBASE, Scopus, ProQuest, Web of Science, EBSCOhost, Cochrane and preprint servers.
Aim: To synthesize the evidence on the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in adolescents with overweight or obesity.
Materials And Methods: For this systematic review and network meta-analysis, we searched five databases and registries until 2 March 2024 for eligible randomized controlled trials (RCTs). The primary outcome was weight change.
Background: Initial randomised controlled trials (RCTs) showed that prophylactic azithromycin in pregnant women improved maternal and neonatal outcomes; however, the recent evidence did not show any benefit to neonatal survival. There is conflicting evidence over the role of azithromycin prophylaxis in antenatal and intrapartum periods. We explored whether azithromycin prophylaxis in pregnant women improves maternal and neonatal outcomes.
View Article and Find Full Text PDFBackground: Mental health disorders in pregnant women have been related to unfavorable obstetric and neonatal outcomes. Obsessive-compulsive disorder (OCD) significantly distresses mothers and affects the maternal-infant bond.
Objectives: The present meta-analysis and systematic review aimed to assess the association of maternal OCD with adverse feto-maternal outcomes.
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- Acute-on-chronic liver failure (ACLF) is a significant health issue, especially among patients with autoimmune hepatitis (AIH), with this study aiming to evaluate its prevalence and impact on treatment outcomes.
- The research involved analyzing data from six studies, encompassing 985 AIH patients, and found a pooled prevalence of ACLF at 12%, with high heterogeneity in the results.
- Treatment response showed that about 71% of patients achieved complete remission after one year, but the mortality rate within this group was concerningly high at 32%.
Introduction: Diabetes and depression are among the 10 biggest health burdens globally. They often coexist and exhibit a strong bidirectional relationship. Depression leads to decreased adherence to self-care activities.
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