A novel meta learning based stacked approach for diagnosis of thyroid syndrome.

Thyroid syndrome, a complex endocrine disorder, involves the dysregulation of the thyroid gland, impacting vital physiological functions. Common causes include autoimmune disorders, iodine deficiency, and genetic predispositions. The effects of thyroid syndrome extend beyond the thyroid itself, affecting metabolism, energy levels, and overall well-being.

Microstructural Evolution of Quaternary AlCoCrNi High-Entropy Alloys during Heat Treatment.

This study examines the microstructural evolution and mechanical properties of quaternary AlCoCrNi high-entropy alloys after heat treatment at 873 K for 72 and 192 h. The changes in nanostructure and phase transformation based on the heat treatment duration were as follows: B2 dendrite + BCC interdendrite and sigma phases after 72 h; B2 dendrite and interdendritic sigma phases + BCC after 192 h. After annealing, the morphology of the dendritic region shifted from spherical to needle-like, and the interdendritic region transformed from a spinodal-like to a plate-like morphology.

Modulating effects of heat-killed and live PSC102 on the immune response and gut microbiota of cyclophosphamide-treated rats.

In the present study, we investigated the potential immunomodulatory effects of heat-killed (hLR) and live PSC102 (LR; formerly PSC102) in RAW264.7 macrophage cells and Sprague-Dawley rats. RAW264.

Optimizing tylosin dosage for co-infection of and in pigs using pharmacokinetic/pharmacodynamic modeling.

Formulating a therapeutic strategy that can effectively combat concurrent infections of () and () can be challenging. This study aimed to 1) establish minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), time kill curve, and post-antibiotic effect (PAE) of tylosin against and pig isolates and employ the MIC data for the development of epidemiological cutoff (ECOFF) values; 2) estimate the pharmacokinetics (PKs) of tylosin following its intramuscular (IM) administration (20 mg/kg) in healthy and infected pigs; and 3) establish a PK-pharmacodynamic (PD) integrated model and predict optimal dosing regimens and PK/PD cutoff values for tylosin in healthy and infected pigs. The MIC of tylosin against both 89 and 363 isolates of and strains spread widely, ranging from 1 to 256 μg/mL and from 0.

Potential anticancer and antioxidant lauric acid-based hydrazone synthesis and computational study toward the electronic properties.

The modification of natural products is one of the key areas of synthetic organic chemistry for obtaining valuable chemical building blocks that have medicinal significance. In this study, lauric acid-based hydrazones, namely ()-'-(2-nitrobenzylidene)dodecanehydrazide (NBDH), ()-'-(naphthalen-1-ylmethylene)dodecanehydrazide (NMDH), and ()-'-(4-fluorobenzylidene)dodecanehydrazide (FBDH), were synthesized and characterized using spectroscopic techniques. The newly synthesized lauric acid-based hydrazones were screened for their anticancer and antioxidant potential.

Amorphization-Driven Lithium Ion Storage Mechanism Change for Anomalous Capacity Enhancement.

Capacity fading as a function of lithiation/delithiation cycles is a major limitation of Li-ion batteries. Most Li storage materials are susceptible to this phenomenon due to the degradation of the crystal structure and particle integrity as a result of volume changes associated with lithiation/delithiation processes and/or irreversible redox reactions. However, some Li storage materials show an increase in capacity with an increase in cycles; this phenomenon has been termed "negative fading.

Probing the behavior and kinetic studies of amphiphilic acrylate copolymers with bovine serum albumin.

This article presents that acrylate copolymers are the potential candidate against the adsorption of bovine serum albumin (BSA). A series of copolymers poly(methyl methacrylate) (pMMA), poly(3-sulfopropyl methacrylate-co-methyl methacrylate) p(SPMA-co-MMA), and poly(dimethylaminoethyl methacrylate-co-methyl methacrylate) p(DMAEMA-co-MMA) were synthesized via free radical polymerization. These amphiphilic copolymers are thermally stable with a glass transition temperature (Tg) 50-120 °C and observed the impact of surface charge on amphiphilic copolymers to control interactions with the bovine serum albumin (BSA).

Physiological properties of indigenous lytic bacteriophages as monophage suspension and cocktail against poultry-adapted typhoidal variants.

The emergence and spread of multidrug resistance among pathogens of the agro-food sector is increasing at an alarming rate, which has directed attention to the search for alternative to antibiotic therapy. The present work studied the physiological and population dynamics of lytic bacteriophages against avian-adapted . Out of 28 positive samples, four bacteriophage isolates (SalØ-ABF37, SalØ-RCMPF12, SalØ-MCOH26, SalØ-DNLS42) were selected based on their ability to clearly lyse bacterial test strains.

A pharmacodynamic investigation to assess the synergism of orbifloxacin and propyl gallate against .

() infections are becoming increasingly difficult to treat, as antibiotic-resistant variants proliferate. Studies on novel methods to combat the spread of resistance and improve the performance of current antibiotics are vital. We aimed to boost the efficacy of the antibiotic orbifloxacin (ORB) against by combining it with a phenolic component, propyl gallate (PG).

Optimize PLA/EVA Polymers Blend Compositional Coating for Next Generation Biodegradable Drug-Eluting Stents.

In this research work, polymer blends of poly-lactic acid (PLA)/ethylene vinyl acetate (EVA) were prepared as the drug carrier materials for a bi-layer drug-loaded coating film for coronary stents. Different optimum compositions of blends were prepared by using an intense mixer. Then, the blends were hot-pressed and later cold-pressed to prepare for films of different thickness.

Microbiota modulation and anti-obesity effects of fermented Pyrus ussuriensis Maxim extract against high-fat diet-induced obesity in rats.

Pyrus ussuriensis Maxim (Korean pear) has been used for hundreds of years as a traditional herbal medicine due to its strong phytochemical profile and pharmacological efficacy. In this study, we evaluated the anti-obesity potential of Pyrus ussuriensis Maxim extracts (PUE) and investigated the underlying mechanisms using a combination of in vitro, in vivo, and microbiota regulation approaches. In an adipogenesis assay, the fermented (F)PUE and non-fermented (NF)PUE significantly reduced the differentiation of 3T3-L1 preadipocyte in a dose-dependent manner with an IC of 85.

The SARS-CoV-2 Antibodies, Their Diagnostic Utility, and Their Potential for Vaccine Development.

Antibodies (Abs) are important immune mediators and powerful diagnostic markers in a wide range of infectious diseases. Understanding the humoral immunity or the development of effective antibodies against SARS-CoV-2 is a prerequisite for limiting disease burden in the community and aids in the development of new diagnostic, therapeutic, and vaccination options. Accordingly, the role of antiviral antibodies in the resistance to and diagnosis of SARS-CoV-2 infection was explored.

Prevalence and determinants of anemia among resident female university students from Southern Punjab, Pakistan.

Health and nutritional status of the women of reproductive age (WRA) is expected to be influenced with women literacy status alongside other sociodemographic indicators. However, data are scant to validate if literate young women have lower incidence of anemia prevalence. Nexus to the problem stated, a cross-sectional study was conducted on 1,541 female resident university students (FRUS) aged 17-35 years from a public sector university located in Southern Punjab, Pakistan.

Surface State-Assisted Delayed Photocurrent Response of Au Nanocluster/TiO Photoelectrodes.

Gold nanoclusters (NCs) can be used as sensitizers to extend the absorption capabilities of TiO as photoelectrodes. However, the adsorption of NCs also creates additional surface states on the TiO surface, which gives rise to intricacies in the understanding of various interfacial phenomena occurring in NC-sensitized TiO. One of the complexities that have recently been discovered is the size-dependent hole-transfer mechanism.

Nanostructured chromium-based broadband absorbers and emitters to realize thermally stable solar thermophotovoltaic systems.

The efficiency of traditional solar cells is constrained due to the Shockley-Queisser limit, to circumvent this theoretical limit, the concept of solar thermophotovoltaics (STPVs) has been introduced. The typical design of an STPV system consists of a wideband absorber with its front side facing the sun. The back of this absorber is physically attached to the back of a selective emitter facing a low-bandgap photovoltaic (PV) cell.

Anti-Obesity Effects of Extract in High-Fat Diet-Induced Obese Rats.

Obesity is becoming a global epidemic as a result of high-calorie food intake and unhealthy lifestyles. Different marine plants, especially brown algae (), are traditionally used to treat different health-related issues. The study was carried out to investigate the anti-obesity properties of 70% ethanol extract.

Exploring the Effect of Cation Vacancies in TiO: Lithiation Behavior of n-Type and p-Type TiO.

TiO offers several advantages over graphite as an anode material for Li-ion batteries (LIBs) but suffers from low electrical conductivity and Li-diffusion issues. Control over defect chemistry has proven to be an effective strategy to overcome these issues. However, defect engineering has primarily been focused on oxygen vacancies (V).

Enabling remote learning system for virtual personalized preferences during COVID-19 pandemic.

The education system worldwide has been affected by the Corona Virus Diseases 2019 (COVID-19) pandemic, resulting in the interruption of all educational institutions. Moreover, as a precautionary measure, the lockdown has been imposed that has severely affected the learning processes, especially assessment activities, including exams and viva. In such challenging situations, E-learning platforms could play a vital role in conducting seamless academic activities.

Immunomodulatory Effects of Asiaticoside Against -Infected Macrophages.

Macrophages provide the first line of defense against infection in the gastrointestinal tract by inducing a variety of inflammatory and antimicrobial responses. Secondary metabolites of plants are used as drugs against infections that are resistant to common antibiotics. In this study, the innate effects of asiaticoside on the proinflammatory activity of mouse macrophages infected with were investigated.

Fourier transform and grating-based spectroscopy with a mid-infrared supercontinuum source for trace gas detection in fruit quality monitoring.

We present a multi-species trace gas sensor based on a fast, compact home-built Fourier transform spectrometer (FTS) combined with a broadband mid-infrared supercontinuum (SC) source. The spectrometer covers the spectral bandwidth of the SC source (2 - 4 µm) and provides a best spectral resolution of 1 GHz in 6 seconds. It has a detection sensitivity of a few hundred of ppbv Hz for different gas species.

Protective Effect of Maxim. Extract against Ethanol-Induced Gastritis in Rats.

Maxim (Korean pear) has been used for hundreds of years as a traditional herbal medicine for asthma, cough, and atopic dermatitis in Korea and China. Although it was originally shown to possess anti-inflammatory, antioxidant, and antiatopic properties, its gastroprotective effects have not been investigated. In the present study, we evaluated the protective effects of Maxim extract (PUE) against ethanol-induced gastritis in rats.

Antifouling and Flux Enhancement of Reverse Osmosis Membrane by Grafting Poly (3-Sulfopropyl Methacrylate) Brushes.

A commercial thin film composite (TFC) polyamide (PA) reverse osmosis membrane was grafted with 3-sulfopropyl methacrylate potassium (SPMK) to produce PA-g-SPMK by atom transfer radical polymerization (ATRP). The grafting of PA was done at varied concentrations of SPMK, and its effect on the surface composition and morphology was studied by Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), optical profilometry, and contact angle analysis. The grafting of hydrophilic ionically charged PSPMK polymer brushes having acrylate and sulfonate groups resulted in enhanced hydrophilicity rendering a reduction of contact angle from 58° of pristine membrane sample labeled as MH0 to 10° for a modified membrane sample labeled as MH3.