Retina-specific T regulatory cells bring about resolution and maintain remission of autoimmune uveitis.

Experimental autoimmune uveitis (EAU) induced in mice by immunization with the retinal Ag interphotoreceptor retinoid-binding protein (IRBP) is a model of human autoimmune uveitis. We examined whether T regulatory cells (Tregs) found in uveitic eyes are IRBP specific, functionally suppressive, and play a role in natural resolution of disease and in maintenance of remission. Progressive increase of Foxp3(+) Treg to T effector cell (Teff) ratio in uveitic eyes correlated with resolution of disease.

Beyond the definitions of the phenotypic complications of sickle cell disease: an update on management.

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG → GTG) in exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position 6 of the β globin polypeptide chain. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing multiple phenotypic expressions that constitute the various complications of sickle cell disease in general and sickle cell anemia in particular. The disease itself is chronic in nature but many of its complications are acute such as the recurrent acute painful crises (its hallmark), acute chest syndrome, and priapism.

Spectral-Domain OPTICAL COHERENCE TOMOGRAPHY of a Macular Fold AFTER Retinal Detachment Repair.

Purpose: We report a case with a dry macular fold after retinal detachment repair using spectral-domain optical coherence tomography images (SD-OCT) to evaluate details of the retinal architecture before and after surgical management.

Methods: A 62-year-old man diagnosed with macula-threatening rhegmatogenous retinal detachment underwent primary vitrectomy with an encircling sclera buckle. On post-operative day 5, he was noted to have developed a juxtafoveal retinal fold.

Isolated endogenous Nocardia endophthalmitis after immunosuppression.

Purpose: This study is aimed to report a case of endogenous Nocardia endophthalmitis in the setting of immunosuppression from chronic steroid use.

Methods: A case report was conducted.

Results: A 79-year-old woman presented with decreased vision with floaters in the left eye.

Long-term follow-up of acute retinal necrosis.

Purpose: The purpose of this study was to report long-term visual outcome of acute retinal necrosis.

Methods: Medical records of patients with acute retinal necrosis were reviewed.

Results: Thirty-two patients were diagnosed with acute retinal necrosis from 1998 to 2007.

Sympathetic ophthalmia: incidence of ocular complications and vision loss in the sympathizing eye.

Purpose: To report the frequency on presentation and subsequent incidence of ocular complications and vision loss in patients with sympathetic ophthalmia (SO) and to describe factors associated with decreased vision in the sympathizing eye.

Design: Multicenter retrospective case series.

Setting: Three academic tertiary care uveitis clinics.

Uveitis associated with pediatric behçet disease in the american midwest.

Purpose: To describe demographics, clinical course, treatment, and visual prognosis of uveitis in pediatric patients with Behçet disease, and to compare childhood-onset with adult-onset Behçet uveitis.

Design: Retrospective, observational case series.

Methods: setting: Uveitis service, University of Illinois at Chicago and private office of one of the authors (H.

The Heidelberg Retina Tomograph vs clinical impression in the diagnosis of glaucoma.

Purpose: To compare the sensitivity and the specificity of the Heidelberg Retina Tomograph (HRT) classification of "Glaucoma" or "Normal" with that derived from clinical impression (CI) based on several parameters.

Design: Consecutive observational case series.

Methods: In a retrospective chart review of 200 left eyes of 200 consecutive patients referred to the Glaucoma Service Diagnostic Laboratory of the Wills Eye Hospital, we compared the HRT-based classification of "Glaucoma" or "Normal" with a CI classification of "Definite glaucoma," "Probably glaucoma," "Probably no glaucoma," and "No glaucoma.