Human leukocyte antigen alloimmunization in a randomized trial of amustaline/glutathione pathogen-reduced red cells in complex cardiac surgery patients.

Background: Although alloimmunization risk of pathogen-reduced (PR) platelets has been studied, the risk has not been reported with PR red blood cells (RBCs).

Study Design And Methods: In a Phase III, randomized, controlled trial (Red Cell Pathogen Inactivation), cardiac or thoracic-aorta surgery patients were randomized to transfusion with amustaline/glutathione PR versus conventional RBCs. Pre-transfusion and Day 28 samples were evaluated for Human leukocyte antigen (HLA) Class I and Class II antibodies at low, medium, and high cutoff values.

Characterizing the antibody response to amustaline/glutathione pathogen-reduced red blood cells.

Background: The clinical significance of natural and treatment-emergent antibodies specific for amustaline/glutathione pathogen-reduced red blood cells (PRRBCs) is not known.

Study Design And Methods: A Phase 3, randomized clinical trial of PRRBCs (ReCePI) compared PRRBCs with conventional RBCs in cardiac or thoracic-aorta surgery. Subjects transfused during and for 7 days after surgery were screened for PRRBC-specific antibodies at baseline, 28 and 75 days post-surgery.

Evaluation of fetal exposure to environmental noise using a computer-generated model.

Acoustic noise can have profound effects on wellbeing, impacting the health of the pregnant mother and the development of the fetus. Mounting evidence suggests neural memory traces are formed by auditory learning in utero. A better understanding of the fetal auditory environment is therefore critical to avoid exposure to damaging noise levels.

In vivo genotoxicity assessment of N-(-9 acridinyl)-b-alanine hydrochloride (S-300) using a validated Pig-a mutagenesis assay.

Background: N-(-9 acridinyl)-b-alanine hydrochloride (S-300) is the main byproduct of red blood cell (RBC) amustaline/glutathione(GSH) pathogen reduction, currently undergoing phase III US clinical trials following successful European studies(1-3). Phosphatidylinositol glycan, class A (Pig-a) X-linked gene mutagenesis is a validated mammalian in vivo mutation assay for genotoxicity, assessed as clonal loss of glycosylphosphatidylinositol-linked CD59 cell-surface molecules on reticulocytes (RETs) and RBCs.

Methods: Male Sprague-Dawley rats received continuous infusion of S-300 up to the maximum feasible dose (240 mg/kg/day-limited by solubility and volume) for 28 days.

Evaluation of the efficacy and safety of amustaline/glutathione pathogen-reduced RBCs in complex cardiac surgery: the Red Cell Pathogen Inactivation (ReCePI) study-protocol for a phase 3, randomized, controlled trial.

Background: Red blood cell (RBC) transfusion is a critical supportive therapy in cardiovascular surgery (CVS). Donor selection and testing have reduced the risk of transfusion-transmitted infections; however, risks remain from bacteria, emerging viruses, pathogens for which testing is not performed and from residual donor leukocytes. Amustaline (S-303)/glutathione (GSH) treatment pathogen reduction technology is designed to inactivate a broad spectrum of infectious agents and leukocytes in RBC concentrates.

Longitudinal MRI in the context of in utero surgery for open spina bifida: A descriptive study.

Introduction: Fetal surgery for open spina bifida (OSB) requires comprehensive preoperative assessment using imaging for appropriate patient selection and to evaluate postoperative efficacy and complications. We explored patient access and conduct of fetal magnetic resonance imaging (MRI) for prenatal assessment of OSB patients eligible for fetal surgery. We compared imaging acquisition and reporting to the International Society of Ultrasound in Obstetrics and Gynecology MRI performance guidelines.

A spatio-temporal atlas of the developing fetal brain with spina bifida aperta.

Spina bifida aperta (SBA) is a birth defect associated with severe anatomical changes in the developing fetal brain. Brain magnetic resonance imaging (MRI) atlases are popular tools for studying neuropathology in the brain anatomy, but previous fetal brain MRI atlases have focused on the normal fetal brain. We aimed to develop a spatio-temporal fetal brain MRI atlas for SBA.

Use of super resolution reconstruction MRI for surgical planning in Placenta accreta spectrum disorder: Case series.

Introduction: Comprehensive imaging using ultrasound and MRI of placenta accreta spectrum (PAS) aims to prevent catastrophic haemorrhage and maternal death. Standard MRI of the placenta is limited by between-slice motion which can be mitigated by super-resolution reconstruction (SRR) MRI. We applied SRR in suspected PAS cases to determine its ability to enhance anatomical placental assessment and predict adverse maternal outcome.

Seismic risk assessment and hotspots prioritization: a developing country perspective.

Natural disasters pose a negative impact not only on human lives but also on infrastructures such as healthcare systems, supply chains, logistics, manufacturing, and service industries. The frequency of such calamities has grown over time, which not only poses a threat to human survival and the living environment but is also detrimental to the economic growth and sustainable development of society. Earthquakes cause the most destruction compared to other natural disasters, especially in developing countries where the conventional reactive approach to dealing with disasters gives less chance for the appropriate utilization of already limited resources.

Machining of Triangular Holes in D2 Steel by the Use of Non-Conventional Electrodes in Die-Sinking Electric Discharge Machining.

Electric discharge machining is relatively a slow process in terms of machining time and material removal rate. The presence of overcut and the hole taper angle caused by the excessive tool wear are other challenges in the electric discharge machining die-sinking process. The areas of focus to solve these challenges in the performance of electric discharge machines include increasing the rate of material removal, decreasing the rate of tool wear, and reducing the rate of hole taper angle and overcut.

Assessment of longitudinal brain development using super-resolution magnetic resonance imaging following fetal surgery for open spina bifida.

Objectives: Prenatal surgery is offered for selected fetuses with open spina bifida (OSB) to improve long-term outcome. We studied the effect of fetal OSB surgery on brain development using advanced magnetic resonance imaging (MRI) techniques to quantify the volume, surface area and shape of cerebral structures and to analyze surface curvature by means of parameters that correspond to gyrification.

Methods: We compared MRI data from 29 fetuses with OSB before fetal surgery (mean gestational age (GA), 23 + 3 weeks) and at 1 and 6 weeks after surgery, with that of 36 GA-matched control fetuses (GA range, 21 + 2 to 36 + 2 weeks).

Hierarchical Activated Carbon-MnO Composite for Wide Potential Window Asymmetric Supercapacitor Devices in Organic Electrolyte.

The consumption of electrical energy grows alongside the development of global industry. Generating energy storage has become the primary focus of current research, examining supercapacitors with high power density. The primary raw material used in supercapacitor electrodes is activated carbon (AC).

Highly selective electrochemical sensing based on electropolymerized ion imprinted polyaniline (IIPANI) on a bismuth modified carbon paste electrode (CPE-Bi) for monitoring Nickel(ii) in river water.

Electrochemical sensors based on ion-imprinting polymers have emerged as an effective analytical tool for heavy metal tracking. This study describes a simple and facile technique for manufacturing a highly selective and sensitive electrode using an ion imprinting polymer on a bismuth-modified carbon paste electrode. The developed sensor applied aniline as a functional monomer and was used for tracking Ni(ii) ions.

Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy.

Magnetic resonance imaging (MRI) assessment of fetal blood oxygen saturation (SO ) can transform the clinical management of high-risk pregnancies affected by fetal growth restriction (FGR). Here, a novel MRI method assesses the feasibility of identifying normally grown and FGR fetuses in sheep and is then applied to humans. MRI scans are performed in pregnant ewes at 110 and 140 days (term = 150d) gestation and in pregnant women at 28  ± 2 weeks to measure feto-placental SO .

Evaluation of amotosalen and UVA pathogen-reduced apheresis platelets after 7-day storage.

Background: Amotosalen/UVA pathogen-reduced platelet components (PRPCs) with storage up to 7 days are standard of care in France, Switzerland, and Austria. PRPCs provide effective hemostasis with reduced risk of transfusion-transmitted infections and transfusion-associated graft versus host disease, reduced wastage and improved availability compared with 5-day-stored PCs. This study evaluated the potency of 7-day PRPCs by in vitro characterization and in vivo pharmacokinetic analysis of autologous PCs.

Lead-Free Aurivillius Phase BiLaNbMnO: Structure, Ferroelectric, Magnetic, and Magnetodielectric Effects.

Aurivillius phase BiLaNbMnO, derived from ferroelectric PbBiNbO by simultaneous substitution of the -site and -site cations, was synthesized using a molten-salt method. Here, we discuss the structure-property relationships in detail. X-ray and neutron diffraction show that BiLaNbMnO adopts an 2 orthorhombic crystal structure.

Developments in functional imaging of the placenta.

The placenta is both the literal and metaphorical black box of pregnancy. Measurement of the function of the placenta has the potential to enhance our understanding of this enigmatic organ and serve to support obstetric decision making. Advanced imaging techniques are key to support these measurements.

What brain abnormalities can magnetic resonance imaging detect in foetal and early neonatal spina bifida: a systematic review.

Purpose: Open spina bifida (OSB) encompasses a wide spectrum of intracranial abnormalities. With foetal surgery as a new treatment option, robust intracranial imaging is important for comprehensive preoperative evaluation and prognostication. We aimed to determine the incidence of infratentorial and supratentorial findings detected by magnetic resonance imaging (MRI) alone and MRI compared to ultrasound.

Super-resolution Reconstruction MRI Application in Fetal Neck Masses and Congenital High Airway Obstruction Syndrome.

Objective: Reliable airway patency diagnosis in fetal tracheolaryngeal obstruction is crucial to select and plan ex utero intrapartum treatment (EXIT) surgery. We compared the clinical utility of magnetic resonance imaging (MRI) super-resolution reconstruction (SRR) of the trachea, which can mitigate unpredictable fetal motion effects, with standard 2-dimensional (2D) MRI for airway patency diagnosis and assessment of fetal neck mass anatomy.

Study Design: A single-center case series of 7 consecutive singleton pregnancies with complex upper airway obstruction (2013-2019).

Hierarchical Structure and Magnetic Behavior of Zn-Doped Magnetite Aqueous Ferrofluids Prepared from Natural Sand for Antibacterial Agents.

This study performs natural sand-based synthesis using the sonochemical route for preparing Zn-doped magnetite nanoparticles. The nanoparticles were dispersed in water as a carrier liquid to form Zn-doped magnetite aqueous ferrofluids. Structural data analysis indicated that the Zn-doped magnetite nanoparticles formed a nanosized spinel structure.

Cortical spectral matching and shape and volume analysis of the fetal brain pre- and post-fetal surgery for spina bifida: a retrospective study.

Purpose: A retrospective study was performed to study the effect of fetal surgery on brain development measured by MRI in fetuses with myelomeningocele (MMC).

Methods: MRI scans of 12 MMC fetuses before and after surgery were compared to 24 age-matched controls without central nervous system abnormalities. An automated super-resolution reconstruction technique generated isotropic brain volumes to mitigate 2D MRI fetal motion artefact.

Automatic Number Plate Recognition:A Detailed Survey of Relevant Algorithms.

Technologies and services towards smart-vehicles and Intelligent-Transportation-Systems (ITS), continues to revolutionize many aspects of human life. This paper presents a detailed survey of current techniques and advancements in Automatic-Number-Plate-Recognition (ANPR) systems, with a comprehensive performance comparison of various real-time tested and simulated algorithms, including those involving computer vision (CV). ANPR technology has the ability to detect and recognize vehicles by their number-plates using recognition techniques.

Synthesis of FeO/Ag nanohybrid ferrofluids and their applications as antimicrobial and antifibrotic agents.

To date, the search for creating stable ferrofluids with excellent properties for biomedical application is one of the challenging scientific and practical investigations. In this study, novel FeO/Ag nanohybrid ferrofluids from iron sand were synthesized using a double-layer method. The FeO/Ag nanocomposites exhibited stable crystallite sizes of 11.

Design and Experimental Analysis of Multiband Frequency Reconfigurable Antenna for 5G and Sub-6 GHz Wireless Communication.

A low-profile frequency reconfigurable monopole antenna operating in the microwave frequency band is presented in this paper. The proposed structure is printed on Flame Retardant-4 (FR-4) substrate having relative permittivity of 4.3 and tangent loss of 0.