Publications by authors named "Mufeng Gu"
Calciphylaxis is a rare cutaneous vascular disease that manifests with intolerable pains, non-healing skin wounds, histologically characterized by calcification, fibrointimal hyperplasia, and microvessel thrombosis. Currently, there are no standardized guidelines for this disease. Recent studies have recognized a high prevalence of thrombophilias and hypercoagulable conditions in calciphylaxis patients.
View Article and Find Full Text PDFBackground: This study aimed to investigate the dose-response association between alcohol consumption and atrial fibrillation (AF) risk.
Methods: PubMed, Embase, Cochrane Library, and Web of Science were systematically searched using keywords related to alcohol and AF from the establishment of databases up to 1 March 2021. Prospective studies examining the impact of alcohol on the risk of AF with hazard ratios (HRs) were included.
It is uncertain whether Bmi-1 deficiency could lead to skin aging by redox imbalance and DNA damage. In this study, we first confirmed that Bmi-1 had a relatively high expression level in the skin and Bmi-1 expression levels gradually decreased with age. Then, we studied the role of Bmi-1 in the skin using a Bmi-1 mouse model.
View Article and Find Full Text PDFCalciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis, with high mortality and no proven therapy. Here, we reported a severe uremic calciphylaxis patient with progressive skin ischemia, large areas of painful malodorous ulcers, and mummified legs. Because of the worsening symptoms and signs refractory to conventional therapies, treatment with human amnion-derived mesenchymal stem cells (hAMSCs) was approved.
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- The study investigates the role of BTBD7_hsa_circ_0000563, a circular RNA located on chromosome 14, in relation to atherosclerosis and identifies proteins regulated by its expression in coronary artery segments.
- Using RT-qPCR to measure expression levels and proteomic analysis to examine protein differences, the research found lower BTBD7_hsa_circ_0000563 levels in severely narrowed arteries and identified 49 proteins with significant expression changes correlated with its levels.
- The findings suggest that BTBD7_hsa_circ_0000563 may play a critical role in atherosclerotic changes, prompting the need for further studies to clarify its mechanisms and functions.
In order to investigate novel biomarkers for the detection of coronary artery disease for effective therapeutic targets, a comprehensive understanding of the protein networks and protein expression abundance in coronary artery samples is required. This was established by means of liquid chromatography (LC)‑mass spectrometry (MS)/MS analysis in the present study. A total of 20 human coronary artery specimens from 2 autopsied adults were employed in the present study.
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- Circular RNAs (circRNAs) are stable molecules that could serve as biomarkers and treatment targets for coronary artery disease due to their role in gene regulation.
- The study involved analyzing circRNAs from the coronary arteries of an 81-year-old man who died from a heart attack, revealing a total of 1,259 known and 381 new circRNAs through RNA sequencing.
- The research identified 66 circRNAs that were significantly regulated based on the presence of atherosclerosis, suggesting their potential involvement in the disease and their applicability in diagnostics or treatment.
The use of human tissue is critical for gross anatomy education in the health professions. Chinese medical colleges have faced a shortage of anatomical specimens over the past decade. While body donation plays an important role in overcoming this gap, this practice has only recently been introduced in China, and the donation rate is relatively low and fraught with a number of difficulties.
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