Publications by authors named "Mufa Yuan"
Background: Simethicone (SIM) is a commonly used antifoaming agent in the clinic. However, it has not been clarified whether SIM can improve the quality of intestinal preparation and the detection rates of adenomas (ADR) and polyps (PDR). This systematic review and meta-analysis were carried out to mainly evaluate the effect of SIM in bowel preparation for colonoscopy.
View Article and Find Full Text PDFBackground: Early detection of colorectal cancer (CRC) and precancerous lesion is vitally important for mitigating CRC morbidity and mortality. Aberrant DNA methylations in certain promoter regions have been identified to be closely associated with CRC development and progression, suggesting their potential as diagnostic biomarkers for early detection. In this study, we evaluated the performance of methylated in stool specimens as a potential biomarker for CRC detection.
View Article and Find Full Text PDFArticle Synopsis
- Aberrant DNA methylation has potential as a biomarker for early detection of colorectal cancer (CRC), particularly through analysis of stool DNA samples.
- A study evaluated the methylation levels of specific genes in 198 CRC patients, 20 advanced adenoma patients, and controls, finding significantly higher levels in CRC and advanced adenoma groups compared to those with small polyps or no disease.
- The tested methylation markers showed sensitivities of 77.3% and 85.9% and specificities of 91.5% and 95.0% for CRC detection, suggesting that stool DNA tests could serve as an effective alternative for CRC screening.