Theoretical Modeling of the Interactions of CoFeO-BaTiO Magnetoelectric Nanoparticles with Cancer and Healthy Cells.

Introduction: The effectiveness of pharmaceutical treatment methods is vital in cancer treatment. In this context, various targeted drug delivery systems are being developed to minimize or eliminate existing deficiencies and harms. This study aimed to model the interaction of MEN-based drug-targeting systems with cancer cells and determine the properties of interacting MENs.

The clinical impact of chronopharmacology on current medicine.

One of the goals of clinical pharmacology is to optimize patient treatment by adopting new treatment strategies which will increase the efficacy of the treatment and decrease the adverse effects of the drugs. In the literature, it has shown that the effectiveness and toxicity of medications can vary significantly based on when they are administered, making timing a crucial factor in treatment plans. Chronopharmacology a relatively new branch of clinical pharmacology focuses on adjusting drug administration times to enhance patient outcomes.

Distinctive Delta and Theta Responses in Deductive and Probabilistic Reasoning.

Introduction: The neural substrates of reasoning, a cognitive ability we use constantly in daily life, are still unclear. Reasoning can be divided into two types according to how the inference process works and the certainty of the conclusions. In deductive reasoning, certain conclusions are drawn from premises by applying the rules of logic.

Assessment of left atrial size, left atrial volume and left ventricular function, and its relation to spontaneous echocardiographic contrast in cats with hypertrophic cardiomyopathy: A preliminary study.

The aim of this study was to evaluate the association between spontaneous echocardiographic contrast (SEC) and left atrial (LA) parameters such as size, volume, and function in cats with hypertrophic cardiomyopathy (HCM). Cats were assigned into following groups: clinically healthy cats (n=8), HCM without SEC (n=12), and HCM with SEC (n=8). Left atrial shortening fraction (LAFS%) and left atrial fractional area change (LAFAC) had statistical significance between groups.

Epstein-Barr Virus-Associated Smooth Muscle Tumor in the Liver Post Kidney Transplant: A Case Report.

Epstein-Barr virus (EBV) is one of the most common causes of infection from the herpes virus family which also possesses oncogenic potential. EBV-associated smooth muscle tumors (EBV-SMT) are often found in the CNS but here we present the case of a 50-year-old woman with EBV-SMT in the liver. This patient had a kidney transplant in 2009 and had been undergoing immunosuppressive therapy to support her transplant.

Exploring the anti‑inflammatory activity of boron compounds through the miR‑21/PTEN/AKT pathway in cecal ligation and puncture‑induced sepsis.

The present study investigated the impact of boric acid (BA) and borax (BX) on markers of inflammation and modifications in miR‑21/PTEN/AKT pathway genes in the liver and kidney tissues of Sprague Dawley male rats with sepsis induced by cecal ligation and puncture (CLP). A total of 60 male Sprague Dawley rats were randomly divided into 6 groups, each containing 10 animals as follows: Control, CLP (where the model was created), 20 mg/kg BX (CLP + BX1), 40 mg/kg BX (CLP + BX2), 20 mg/kg BA (CLP + BA1) and 40 mg/kg BA (CLP + BA2). Liver and kidney tissues were analyzed for histopathological changes, immunopositivity for tumor necrosis factor‑α, interleukin (IL)‑6 and IL‑10, and gene expression of microRNA‑21 (miR‑21), phosphatase and tensin homolog (PTEN) and AKT.

Acellular dermal matrices in reconstructive surgery; history, current implications and future perspectives for surgeons.

Large-scale defects of body in the reconstructive surgical practice, and the helplessness of their repair with autologous tissues, have been an important factor in the development of artificial biological products for the temporary, definitive, or staged repair of these defects. A major advance in the field of plastic and other reconstructive surgery in this regard has been the introduction and successful use of acellular dermal matrices (ADMs). In recent years, not only the type of tissue from which ADMs are produced, product range, diversity and areas of use have increased, but their use in reconstructive fields, especially in post oncologic breast surgery, has become highly regarded and this has favored ADMs to be a potential cornerstone in specific and well-defined surgical fields in future.

Investigation of integron gene cassettes in trimethoprim-sulfamethoxazole-resistant Acinetobacter baumannii isolates.

Background: The spread of antibiotic-resistance genes among healthcare-associated infections (HAIs) poses serious problems in the treatment of these infections. Recently, these resistance genes have also been shown to be present in integrons.

Objectives: By focusing on integron-mediated mechanisms of antibiotic resistance, we sought to elucidate the genetic determinants underpinning the development of multidrug resistance in clinical isolates of Acinetobacter baumannii.

The Significance of SARC-F Scores in One-Year Mortality of Adults with High Nutritional Risk with Cancer.

Sarcopenia, being prevalent in up to 70% of cancer patients, is associated with adverse clinical outcomes. The use of the Simple Questionnaire for Rapidly Diagnose of Sarcopenia (SARC-F), a questionnaire developed to screen for sarcopenia, remains to be investigated in cancer patients. The aim in this study was to assess the prognostic value of SARC-F on one-year mortality in cancer patients at high nutritional risk.

Attitudes toward and exposure to gender discrimination in work life by pulmonologists and thoracic surgeons: a questionnaire-based survey among Turkish thoracic society members.

Background: This study aimed to evaluate attitudes toward and exposure to gender discrimination in work life by chest diseases specialists and thoracic surgeons.

Methods: A total of 275 members of Turkish Thoracic Society (TTS) were included on a voluntary basis in this online cross-sectional questionnaire-survey using an internal member-only social media platform of TTS. The questionnaire form elicited items on sociodemographic characteristics, occupational characteristics and gender discrimination in work life (general opinions, attitudes and exposure).

How would you like your proximal femoral nail - with a monocortical recon plate, with cable, or neat? A functional and radiological study of reverse oblique (AO/OTA 31-A3) intertrochanteric femur fractures.

Objective: Intertrochanteric femur fractures (ITFF), more so reverse oblique fractures (AO/OTA 31-A3), are the most challenging clinically, with significant morbidity and mortality. Early stable fixation should be achieved to allow early mobilization and reduce complications. This study evaluates the functional and radiological outcomes of three Proximal Femoral Nail (PFN) techniques - PFN alone, Cable + PFN, and Monocortical reconstruction plate (MRP) + PFN- in managing reverse oblique ITFF, to determine the most ideal of them.

External validation and performance analysis of a deep learning-based model for the detection of intracranial hemorrhage.

Purpose: We aimed to investigate the external validation and performance of an FDA-approved deep learning model in labeling intracranial hemorrhage (ICH) cases on a real-world heterogeneous clinical dataset. Furthermore, we delved deeper into evaluating how patients' risk factors influenced the model's performance and gathered feedback on satisfaction from radiologists of varying ranks.

Methods: This prospective IRB approved study included 5600 non-contrast CT scans of the head in various clinical settings, that is, emergency, inpatient, and outpatient units.

Cyclodextrin as a singular oligosaccharide: Recent advances of health benefit and in food applications.

Cyclodextrins (CDs) are cyclic oligosaccharides derived from the enzymatic degradation of starch. Their distinct molecular shape, which resembles a truncated cone with a hydrophobic interior and a hydrophilic outer surface, enables the formation of inclusion complexes via host-guest interactions. These complexes facilitate beneficial modifications such as enhancing the solubility and stabilizing unstable guest molecules.

Androgen receptor CAG repeat polymorphism might be a possible cause of familial constitutional delay of growth and puberty.

Background: Induction of puberty in boys with constitutional delay of growth and puberty (CDGP) through a short course of low-dose testosterone therapy indicates the critical interaction between testosterone and the androgen receptor (AR) during the activation and maturation of the hypothalamic-pituitary-gonadal axis at puberty onset. Previous studies have shown an inverse relationship between the CAG repeat length and the transactivation function or expression level of the AR gene.

Objective: We aimed to investigate whether the AR CAG repeat polymorphism has any implications on pubertal delay.

Combined sonographic optic nerve sheath diameter and cerebral oximeter for predicting neurological outcome after cardiac arrest.

Cardiac arrest (CA) remains a critical global health issue with high rates of mortality and morbidity. Accurate prediction of neurological outcomes in post-CA patients is essential for optimizing management strategies. Optic nerve sheath diameter (ONSD) and near-infrared spectroscopy (NIRS) are emerging as promising tools for evaluating brain oxygenation and intracranial pressure.

Sacubitril/Valsartan Combination Partially Improves Cardiac Systolic, but Not Diastolic, Function through β-AR Responsiveness in a Rat Model of Type 2 Diabetes.

Cardiovascular complications are the major cause of diabetes mellitus-related morbidity and mortality. Increased renin-angiotensin-aldosterone system activity and decreased β-adrenergic receptor (β-AR) responsiveness contribute to diabetic cardiac dysfunction. We evaluated the effect of sacubitril/valsartan (neprilysin inhibitor plus angiotensin receptor antagonist combination) and valsartan treatments on the diabetic cardiac function through β-AR responsiveness and on protein expression of diastolic components.

Insights into the Biological Activity and Bio-Interaction Properties of Nanoscale Imine-Based 2D and 3D Covalent Organic Frameworks.

Covalent Organic Frameworks (COFs) emerged as versatile materials with promising potential in  biomedicine. Their customizable functionalities and tunable pore structures make them valuable for various biomedical applications such as biosensing, bioimaging, antimicrobial activity, and targeted drug delivery. Despite efforts made to create nanoscale COFs (nCOFs) to enhance their interaction with biological systems, a comprehensive understanding of their inherent biological activities remains a significant challenge.

Boric acid and zinc borate doped graphene hydrogels designed for burn treatment: In vitro viability-biocompatibility tests and microbiological analysis.

Boron, an essential element for human, can be a key factor in wound healing. For this reason, in this study, role of boron products (boric acid and zinc borate) and boron product doped new synthesized graphene hydrogels was investigated for burn healing via in vitro viability-biocompatibility tests and microbiological analysis. It has been determined that boric acid and zinc borate are effective against microbial agents that are frequently seen in burns.

A Novel Bioprotective Strain of F2-Physiological, Genetical, and Antimicrobial Characterization.

is a member of lactic acid bacteria that improves the quality of fermented foods while also having a positive impact on human health. In this study, F2 was studied for characteristics such as biochemical and genetic identification, metabolite production, antimicrobial activity, and plasmid content. This strain exerts antimicrobial activity against some Gram-positive and Gram-negative pathogens (, , , and ) with inhibition zone diameters ranging between 17.

Corrigendum to "Cadmium sulfide-induced toxicity in the cortex and cerebellum: and studies" [Toxicol. Rep. 7 (2020) 637-648].

[This corrects the article DOI: 10.1016/j.toxrep.

Ochratoxin a levels in Turkish coffee: a probabilistic health risk assessment via Monte Carlo simulation.

Throughout history, Turkish coffee has been the most widely consumed type of coffee in Turkey. Therefore, the goal of this study was to determine the amount of ochratoxin A (OTA) present in Turkish coffee and to analyze any potential health hazards. A total of 41 Turkish coffees were collected and analyzed for OTA activity using a competitive enzyme immunoassay (ELISA).

Assessing workplace well-being in healthcare: The violence-prevention climate and its relationship with workplace happiness.

Aim: To identify the relationship between the violence-prevention climate and workplace happiness in hospitals. The secondary objective is to adapt a valid and reliable scale to a different culture in healthcare settings.

Background: Healthcare settings are not immune to the harmful effects of violence, which can exacerbate existing challenges such as staff shortages.