Publications by authors named "Mueller-Mottet S"
Altitude exposure induces hypoxaemia in patients with chronic obstructive pulmonary disease (COPD), particularly during sleep. The present study tested the hypothesis in patients with COPD staying overnight at high altitude that nocturnal arterial hypoxaemia is associated with impaired cerebral tissue oxygenation (CTO). A total of 35 patients with moderate-to-severe COPD, living at <800 m (mean [SD] age 62.
View Article and Find Full Text PDFStudy Objectives: Patients with chronic obstructive pulmonary disease (COPD) have impaired pulmonary gas exchange near sea level. The purpose of the current study was to investigate whether exposure to hypobaric hypoxia during a stay at altitude affects nocturnal oxygen saturation, breathing pattern, and sleep in patients with moderate to severe COPD.
Methods: Thirty-two patients with COPD, median age 67 years, FEV1 59% predicted, PaO2 68 mmHg, living below 800 m, underwent polysomnography and questionnaire evaluations in Zurich (490 m), and in Swiss Alpine villages at 1650 and 2590 m, for two nights each, in random order.
Article Synopsis
- - This study aimed to assess how traveling to high altitudes affects exercise performance and symptoms in lowlanders with Chronic Obstructive Pulmonary Disease (COPD) using a randomized crossover trial design.
- - Forty COPD patients participated in the trial, spending two days at different altitudes (490 m, 1,650 m, and 2,590 m) while their exercise capacity (measured by the six-minute walk distance) and health effects were monitored.
- - Results showed that exercise performance decreased significantly at higher altitudes, with about 24% of participants needing oxygen therapy or relocation due to adverse health effects, highlighting the need for caution in advising COPD patients about altitude travel.
Background: Registries are important for real-life epidemiology on different pulmonary hypertension (PH) groups.
Objective: To provide long-term data of the Swiss PH registry of 1998-2012.
Methods: PH patients have been classified into 5 groups and registered upon written informed consent at 5 university and 8 associated hospitals since 1998.