Publications by authors named "Mueller C"
Article Synopsis
- The study investigates the impact of peri-procedural myocardial injury (PPMI) after transcatheter aortic valve implantation (TAVI) using the updated VARC-3 criteria compared to the previous VARC-2 criteria.
- High-sensitivity cardiac troponin T (hs-cTnT) levels were assessed pre- and post-procedure, with elevated baseline levels being significant predictors of all-cause mortality and major cardiac adverse events within one year post-TAVI.
- The findings indicate that VARC-3 criteria offered better prognostic insights regarding patient outcomes, with patients meeting VARC-3 criteria experiencing higher mortality rates than those meeting VARC-2 criteria.
Impact of new-onset atrial fibrillation in patients with ST-segment elevation myocardial infarction.
J Interv Card Electrophysiol
December 2024
Background: New-onset atrial fibrillation (NOAF) complicating ST-segment elevation myocardial infarction (STEMI) remains clinically challenging. The aim of this study was to assess the incidence of NOAF, identify risk factors for the development of atrial fibrillation (AF), and analyze the impact on patient care, therapy, and outcomes during long-term follow-up.
Methods: This retrospective single-center study reviewed consecutive patients undergoing coronary angiography (CAG) for acute STEMI between May 2015 and September 2023.
Background And Aim: The possible clinical utility of Bone Morphogenetic Protein 10 (BMP10), a novel atrial-specific biomarker, is incompletely understood. We aimed to test the hypothesis that BMP10 has high diagnostic and prognostic accuracy in patients presenting with acute dyspnea.
Methods And Results: In a multicenter diagnostic study, BMP10, high-sensitivity cardiac troponin T (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations were determined in patients presenting with acute dyspnea to the emergency department.
The 50th anniversary of the is a milestone that calls for reflection on the many important contributions made by our clinicians, educators, and researchers to the care of older adults. This article was written to highlight not only the issues that have been the focus of our professional attention but also the accomplishments that gerontological nurses have made during the past half century. Edna Stilwell, the inaugural editor, laid out nine objectives for the journal in the first issue, which was published in 1975.
View Article and Find Full Text PDFObjectives: This study investigated the relationships between the cochlear nerve (CN) health and sentence-level speech perception outcomes measured in quiet and noise in postlingually deafened adult cochlear implant (CI) users.
Design: Study participants included 24 postlingually deafened adult CI users with a Cochlear Nucleus device. For each participant, only one ear was tested.
Background/objectives: Secondary mitral regurgitation (MR) is a common valvular heart disease burdening the prognosis of patients with co-existing chronic heart failure. Transcatheter edge-to-edge mitral valve repair (MV-TEER) is a minimally invasive treatment option for high-risk patients. However, the effects of MV-TEER on expanded hemodynamics, tissue perfusion, and quality of life, particularly in patients with advanced renal failure, remain underexplored.
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- IgG4-related disease is an immune disorder that can cause hypertrophic spinal pachymeningitis (HSP), leading to spinal cord and nerve root compression due to infiltration of IgG4-positive plasma cells in the meninges.* -
- A case study of a 45-year-old man with cervical myelopathy showed that surgical decompression and subsequent treatment with methylprednisolone and rituximab led to a full neurological recovery, highlighting effective management of this condition.* -
- An updated literature review covering 52 cases revealed that neurological impairment worsened in 58% of patients, with most lesions affecting the thoracic and cervical spine, indicating the complexities and challenges in diagnosing and treating IgG4-related H
Macroautophagy (often-named autophagy), a catabolic process involving autophagy-related (Atg) genes, prevents the accumulation of harmful cytoplasmic components and mobilizes energy reserves in long-lived and self-renewing cells. Autophagy deficiency affects antigen presentation in conventional dendritic cells (DCs) without impacting their survival. However, previous studies did not address epidermal Langerhans cells (LCs).
View Article and Find Full Text PDFBackground: Knowledge about primary hypoadrenocorticism coexisting with immune-mediated thyroiditis (Schmidt's syndrome) in dogs is limited.
Objective: To evaluate thyroid function in dogs with naturally occurring hypoadrenocorticism before and during treatment.
Animals: Sixty-six client-owned dogs.
Background: Family caregivers of people with dementia are a distinct group due to the particularly stressful and time-intensive care situation at home. Despite these challenges, involving them in research is crucial to better understand and address their specific needs. However, little evidence exists regarding a tailored approach for researchers for this group considering their situation at home.
View Article and Find Full Text PDFConventional navigation systems (CNS) in surgery require strong spatial cognitive abilities and hand-eye coordination. Augmented Reality Navigation Systems (ARNS) provide 3D guidance and may overcome these challenges, but their accuracy and efficiency compared to CNS have not been systematically evaluated. In this randomized crossover study with 36 participants from different professional backgrounds (surgeons, students, engineers), drilling accuracy, time and perceived workload were evaluated using ARNS and CNS.
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- Pulmonary transit time (PTT) measures how long it takes blood to move from the right to the left ventricle and can indicate heart failure-related issues like diastolic dysfunction (DD) and mitral valve regurgitation (MVR).
- In a study of 83 patients using stress perfusion cardiovascular magnetic resonance (CMR) scans, higher PTT and normalized PTT (nPTT) were linked to more severe cases of DD and MVR.
- PTT values under 8 seconds can effectively rule out DD and MVR with a 70% probability, highlighting PTT as a useful and accessible measure for evaluating patients' heart conditions.
Article Synopsis
- This study investigates the impact of extreme weather events, particularly high temperatures, on the occurrence of acute otitis externa (AOE), a common ear condition leading to emergency room visits.
- Analysis of 1522 AOE-related visits from 2015 to 2018 revealed a significant increase in cases following high-temperature days, showing a relative risk increase one day after such events.
- The study also found that both low and high humidity levels reduced immediate AOE-related visits, while higher precipitation and wind speeds were linked to fewer cases over several days.
Protein biomarkers for subtyping breast cancer and implications for future research: a 2024 update.
Expert Rev Proteomics
November 2024
Introduction: Breast cancer subtyping is used clinically for diagnosis, prognosis, and treatment decisions. Subtypes are categorized by cell of origin, histomorphology, gene expression signatures, hormone receptor status, and/or protein levels. Categorizing breast cancer based on gene expression signatures aids in assessing a patient's recurrence risk.
View Article and Find Full Text PDFObjective: Epileptogenesis is linked to neuroinflammation. We hypothesized that local heat production caused by neuroinflammation can be visualized non-invasively in vivo via brain magnetic resonance spectroscopic imaging (MRSI) and MRSI-thermometry (MRSI-t) and that there is a relationship in patients with temporal lobe epilepsy (TLE) between MRSI-t and brain metabolites choline and myo-inositol and between neuroimaging and cellular and serum biomarkers of inflammation.
Methods: Thirty-six (36) participants, 18 with temporal lobe epilepsy (13 females) and 18 age-matched healthy controls (nine females), were enrolled prospectively and underwent MRSI/MRSI-t; TLE participants also provided blood samples.
Diabetes is a well-recognised risk factor for the development of heart failure, with a prevalence higher than 30% in patients with diabetes aged over 60 years. Heart failure often emerges as the primary cardiovascular manifestation in patients with type 2 diabetes and appears to be even more prevalent in type 1 diabetes. In Switzerland, there are approximately 500,000 individuals with diabetes, and the number of affected people has been steadily rising in recent years.
View Article and Find Full Text PDFHealth Mindset and One Year Outcomes in Adult Peritoneal Dialysis (PD) Patients.
SM J Nephrol Kidney Dis
August 2024
Background: Many patients who start peritoneal dialysis (PD) transition to hemodialysis (HD) after a PD-related complication. Patient psychological factors may influence clinical outcomes. One possible factor is health mindset, or patient belief that their health knowledge and ability can change.
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- Repairing recurrent giant paraesophageal hernias (PEH) has a higher complication rate than initial surgeries, which leads to hesitation in performing these procedures unless patients are symptomatic.
- A study analyzed outcomes of revisional PEH repairs compared to primary repairs, focusing on patient demographics and recovery times between 2012 and 2019.
- The research found that while revisional surgeries faced more complications, longer recovery times, and a higher conversion rate to open surgery, the incidence of severe complications was similar to those undergoing primary repairs.
Article Synopsis
- Eftilagimod alpha (efti) is a protein that activates immune cells, potentially overcoming resistance to PD-(L)1 inhibitors, and was tested with pembrolizumab on NSCLC patients who had previously failed anti-PD-(L)1 therapy.
- In a study of 36 patients, efti was administered alongside pembrolizumab, with primary focus on the objective response rate and secondary measures including overall survival and disease control.
- Results showed modest activity with an 8.3% objective response rate and a median overall survival of 9.9 months, particularly benefiting patients with higher PD-(L)1 expression, while the treatment was well-tolerated without severe adverse events.
Article Synopsis
- Glioblastoma (GBM) tumors show diverse genetic and transcriptional profiles, leading to significant variations in how cancer stem cells (CSCs) respond to standard treatments like radiation and temozolomide (TMZ).
- Through targeted proteomics and RNA sequencing, the study found that while differentiating CSCs to an astrocytic state activates certain oncogenic pathways and retains some "stemness," it also increases resistance to TMZ treatment.
- The transcriptional response to treatments was largely influenced by the p53 status of the cells, revealing that both mutant and wild-type p53 models activated a DNA-damage related immune response, indicating potential pathways for improving GBM treatment strategies.
Article Synopsis
- The study focused on pairing naporafenib, a pan-RAF inhibitor, with either rineterkib or trametinib to treat patients with non-small cell lung cancer (NSCLC) and certain genetic mutations.
- Conducted on 216 patients, the research aimed to find safe and effective dosage levels, identifying recommended doses while monitoring for side effects and antitumor activity.
- Results showed dose-limiting toxicities in 16% of patients, with some achieving partial responses; the study established specific dosages that were well-tolerated along with noticeable reductions in certain mRNA levels.