Intriguing tumor, synovial sarcoma: Hard to diagnose, harder to treat.

Background: Synovial sarcoma (SS) is classified as an aggressive high-grade soft tissue sarcoma that predominantly affects the extremities. Despite its prevalence in the extremities (up to 80%), diagnostic and treatment challenges persist. This study aims to address these challenges by providing a comprehensive analysis of SS in extremities, focusing on diagnostic accuracy and treatment outcomes.

Prognostic Value of Blood-Based Inflammatory Markers in Cancer Patients Receiving Immune Checkpoint Inhibitors.

Although immune checkpoint inhibitors (ICIs) have significantly improved cancer treatment, a substantial proportion of patients do not benefit from these therapies, revealing the crucial need to identify reliable biomarkers. Inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), pan-immune inflammation value (PIV), systemic inflammation response index (SIRI), lactate dehydrogenase (LDH), and C-reactive protein (CRP), may provide insights into treatment outcomes. : This study aimed to evaluate the prognostic value of multiple inflammatory markers in patients with cancer receiving ICI-based therapies.

Optimizing Care for Primary Glomerulonephritis: The Role of Thyroid Evaluation.

Background: The coexistence of primary glomerulonephritis and autoimmune thyroid disease has not been investigated.

Objective: This study aimed to assess thyroid morphology using sonography, determine the prevalence of autoimmune thyroid disorders, and evaluate thyroid function status in patients diagnosed with primary glomerulonephritis.

Materials And Methods: This single-center cross-sectional and observational study included 58 consecutive patients with primary glomerulonephritis and 58 healthy controls (HC).

Coexistence of phenylketonuria and tyrosinemia type 3: challenges in the dietary management.

Objectives: Phenylketonuria (PKU) and tyrosinemia type 3 (HT3) are both rare autosomal recessive disorders of phenylalanine-tyrosine metabolism. PKU is caused by a deficiency in phenylalanine hydroxylase (PAH), leading to elevated phenylalanine (Phe) and reduced tyrosine (Tyr) levels. HT3, the rarest form of tyrosinemia, is due to a deficiency in 4-hydroxyphenylpyruvate dioxygenase (HPD).

Noninvasive Approach to Postoperative Bleeding in Patients Undergoing Septorhinoplasty Surgery.

Objectives: In this study, we retrospectively examined the bleeding that occurred in the 5-year patient series.

Materials And Methods: One thousand seven hundred seventy-five patients who underwent septorhinoplasty surgery between 2019 and 2023 were included in the study, and 28 of these patients who presented with bleeding complications were examined. All patients underwent open-technique septorhinoplasty surgery with or without concha intervention and were discharged the next day after overnight hospitalization.

The effect of cognitive behavioral interventions applied to children with anxiety disorders on their anxiety level: A meta-analysis study.

Background: Anxiety disorders are among the most prevalent mental health conditions in childhood, affecting an estimated 10 % to 20 % of children. Cognitive Behavioral Therapy (CBT) is the most commonly employed treatment for these disorders. This study utilizes a meta-analytic approach to evaluate the effectiveness of CBT interventions in reducing anxiety levels among children diagnosed with anxiety disorders.

Highly Flexible Methyl Cellulose/Gelatin Hydrogels for Potential Cartilage Tissue Engineering Applications.

Cartilage damage resulting from trauma demonstrates a poor capacity for repair due to its avascular nature. Cartilage tissue engineering offers a unique therapeutic option for cartilage recovery. In this study, methylcellulose (MC)/gelatin (GEL) hydrogels (MC10G20, MC12.

Prognostic Role of Neutrophil Percentage-to-Albumin Ratio in Patients with Non-ST-Elevation Myocardial Infarction.

: This study aimed to investigate whether neutrophil percentage-to-albumin ratio (NPAR) levels on admission have prognostic significance regarding one-year major adverse cardiovascular and cerebrovascular events (MACCEs) in non-ST-elevation myocardial infarction (NSTEMI) patients. : A total of 464 patients aged 59.2 ± 11.

Evaluation of the antimicrobial effect of encapsulated cumin seed essential oil in chickpea protein-maltodextrin matrix and its potential to extend the shelf life of meatballs.

This study aimed to evaluate the antimicrobial effectiveness of cumin seed essential oil (CEO) after encapsulation in chickpea protein-maltodextrin matrix by spray drying and to provide insight into potential use as a natural ingredient in meat-based products. The surface morphology results of encapsulated CEO showed the dispersion in the wall material matrix, and the observed specific common peaks in the FT-IR spectra of encapsulated and non-encapsulated CEO proved the successful encapsulation. The antibacterial activity of non-encapsulated CEO against BC1402, ATCC 27853, Typhimurium ATCC 0402, ATCC 25923 were first evaluated by disc diffusion assay.

Superconductivity in ordered Li-Al-B compounds.

Using first principles calculations, we show that [Formula: see text] materials have strong electron-phonon coupling, with many having a superconducting critical temperature ([Formula: see text]) that exceeds that of the more familiar [Formula: see text] at ambient pressure. In particular, we find that [Formula: see text] is the most stable member of the family, with [Formula: see text] whilst the peak [Formula: see text] is with [Formula: see text] which has [Formula: see text]. Our results reveal that these materials are both thermodynamically and dynamically stable, with strong electron-phonon coupling, indicating significant potential for practical superconducting applications.

Directed Energy Deposition of Parts with Internal Channels Using Removable Graphite Supports.

Additive manufacturing (AM) techniques have the potential to produce complex parts, and many of these techniques require the use of support structures to prevent deformations and to minimize thermal effects during the printing process, particularly when building overhangs and internal cavities. However, removing the support structures through postprocessing incurs additional costs and time penalties. Unlike other AM techniques, support structures are not used in directed energy deposition (DED) technique due to its working principle.

HER-2 SMASH.

Purpose: Human epidermal growth factor-2 (HER-2) targeted drugs are used in only HER-2 overexpressed cancers. However, only a small portion of these cancer types are HER-2 overexpressed. In this study, we aimed to upregulate HER-2 receptors in MCF-7 breast cancer and HT-29 colon cancer cell cultures, which these cells are not HER-2 upregulated in natural status.

Efficacy and prognostic factors of anti-PD1 and nivolumab-ipilimumab therapy in advanced melanoma patients resistant to prior ICI treatment.

Immune checkpoint inhibitors (ICIs) have significantly improved the five-year survival rate for advanced melanoma. However, many patients exhibit resistance to ICI therapy. This study evaluated the efficacy and prognostic factors of anti-PD-1 (Group A) and nivolumab-ipilimumab (Group B) therapy in patients with advanced melanoma who were resistant to prior ICI therapy.

Evaluating the safety and effectiveness of the sub-400 corneal cross-linking protocol: initial clinical and morphological findings.

Purpose: To assess the safety and the efficacy of the "Sub-400 corneal cross-linking (CXL) protocol" for progressive keratoconus (KC) in ultrathin corneas.

Methods: The study included thirty four patients with progressive KC, who underwent CXL using the "Sub-400" protocol due to intraoperative thinnest corneal pachymetry ranging from 295 to 398 μm after epithelial removal. After the epithelium was removed, the following ultraviolet A irradiation was applied at a fluence of 3 mW/cm and the duration was adjusted based on the specific corneal stromal thickness.

Emerging threats in Сentral Asia: Comparative characterization of organic and elemental carbon in ambient PM in urban cities of Kazakhstan.

This study (June 2022-July 2023) investigates the atmospheric concentrations of carbonaceous species, including organic carbon (OC) and elemental carbon (EC), in PM in two major cities in Kazakhstan. Samples were collected from two sites in Almaty (Seifullin and KazNU) and one in Astana. The results showed that Almaty had significantly higher annual average concentrations of OC (10.

Assessing the outcomes of subinguinal microsurgical varicocelectomy: pulling technique compared to the conventional method.

Introduction: The positive effect of varicocelectomy on sperm parameters (sperm morphology, concentration, motility) and fertility and pregnancy rates has been proven. Although various techniques have been defined for varicocele treatment, varicocelectomy with the pulling technique was first defined in 2017. The aim of this retrospective study is to compare the effectiveness and reliability of subinguinal microsurgical varicocelectomy with the "pulling" technique and conventional subinguinal varicocelectomy.

Investigation of Wettability, Thermal Stability, and Solar Behavior of Composite Films Based on Thermoplastic Polyurethane and Barium Titanate Nanoparticles.

Herein, composite films were produced by incorporating different amounts (1, 3, 5, and 7%) of barium titanate nanoparticles into the thermoplastic polyurethane matrix using a solution casting method. This study examined the impact of the presence and concentration of a barium titanate additive on morphologic properties, mechanical performance, thermal stability, solar behavior, and wettability of produced film samples. The films were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, thermal gravimetric analysis, scanning electron microscope, ultraviolet-visible near-infrared spectrophotometer, water contact angle, and tensile strength measurements.

Can T1W and T2W Dixon Sequences Replace the Standard MRI Protocol in Diagnosing Sacroiliitis?

This study aims to assess the performances of T1‑weighted (T1W) and T2‑weighted (T2W) Dixon sequences as replacements for the standard magnetic resonance imaging (MRI) protocol for diagnosing active and chronic sacroiliitis. This single‑centre, prospective study included 107 patients who underwent 3 Tesla MRIs. The patients with inflammatory low‑back pain (aged 18-50 years) were included.

Does malignancy heighten the risk of rejection in kidney transplant recipients?

Background: Malignancies are the third leading cause of death among kidney transplant recipients. These patients face increased mortality and challenges such as allograft loss and rejection, which may arise from surgical complications, changes in immunosuppressive therapy or the use of chemotherapeutics. This study aims to examine the risk of allograft rejection and loss in kidney transplant recipients diagnosed with malignancies.

Fermented soy products: A review of bioactives for health from fermentation to functionality.

The increasing prevalence of metabolic diseases and the global drive toward achieving Sustainable Development Goals (SDGs) underscore the need for sustainable, nutrient-dense foods. Soybeans (Glycine max), a critical global crop, offer promising solutions; however, their predominant use as animal feed raises concerns regarding food security and environmental sustainability. Fermented soy products-including tempeh, natto, and miso-are rich in bioactive compounds such as peptides and isoflavones, which offer potential therapeutic effects and hold cultural and nutritional significance.

Hippocampal connectivity dynamics and volumetric alterations predict cognitive status in migraine: A resting-state fMRI study.

The etiology of cognitive decline linked to migraine remains unclear, with a growing recurrence rate and potential increased dementia risk among sufferers. Cognitive dysfunction has recently gained attention as a significant problem among migraine sufferers that can be related to alterations in hippocampal function and structure. This study explores hippocampal subfield connectivity and volume changes in migraine patients.

Single Apheresis Session on the 4th Day of Granulocyte Colony-Stimulating Factor Administration Seems Convenient to Collect Enough Peripheral Blood Stem Cells from Healthy Donors.

Background: To minimize adverse events of peripheral blood stem cell (PBSC) collection in healthy donors, it is reasonable to limit the total dose of granulocyte colony-stimulating factor (G-CSF) and/or the number of apheresis days without decreasing of PBSCs yield. Therefore, we have started to collect G-CSF induced PBSCs on day 4 instead of on day 5. So, we retrospectively aimed to investigate the results of this 4-day G-CSF administration.

The Relationship Between the Triglyceride-Glucose Index and Cryptogenic Stroke in Patients with Patent Foramen Ovale.

Objective: This study aimed to investigate the association between the triglyceride-glucose (TyG) index and cryptogenic stroke (CS) in patients diagnosed with patent foramen ovale (PFO) using transesophageal echocardiography (TEE).

Methods: A retrospective, single-center study was conducted at a tertiary education and research hospital from January 2015 to December 2023. The study population included 1017 consecutive patients with sinus rhythm diagnosed with PFO, of whom 210 had CS.