Are Ki-67 and Procalcitonin Expression Levels Useful in Predicting the Biological Behavior of Hepatocellular Carcinoma After Liver Transplantation?

: Examinations of procalcitonin (PCT) and Ki-67 expression levels in hepatocellular carcinoma (HCC) patients who have undergone liver transplantation (LT) through immunohistochemical analyses of tumor tissue may reveal the biological characteristics of the tumor, thus informing the selection of HCC patients for LT. : Hepatectomy specimens from 86 HCC patients who underwent LT were obtained and analyzed immunohistochemically for the expression of PCT and Ki-67. The percentage and intensity of PCT staining, as well as the percentage of Ki-67 expression, were assessed for each patient.

Association of nutritional status indices with gastrointestinal symptoms in systemic sclerosis: a cross-sectional study.

Gastrointestinal (GI) involvement is highly prevalent in systemic sclerosis (SSc) and significantly affects patient quality of life and clinical outcomes. This study investigates the potential of undernutrition scores, namely the Control of Nutritional Status (CONUT) score and the Prognostic Nutrition Index (PNI), in predicting GI involvement in patients with SSc. A total of 82 patients diagnosed with SSc were enrolled in this cross-sectional study.

[Multicentric Screening of Local Antibiotic Resistance in Uncomplicated Urinary System Infections: 1850 Patients from 37 Centers].

This study was aimed to identify the most frequently observed pathogens in uncomplicated urinary tract infections from outpatient urinary isolates obtained across seven different geographical regions in Türkiye and to determine whether the antibiotic resistance rates of these pathogens differ significantly between these regions. The study included patients aged 18 to 65 years who were diagnosed with uncomplicated urinary tract infections and had positive urine cultures from March 2021 to August 2022, across 37 different centers in Türkiye. The participating centers were selected based on their use of the disk diffusion method, in line with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines, to ensure standardization of urine culture data.

The Role of Cardiac Resynchronization Therapy in Heart Failure: A Narrative Review.

Introduction: Structural and functional cardiac defects leading to inadequate tissue oxygenation is known as Heart failure (HF) which is characterized by extensive morbidity and mortality. Pathophysiology of HF involves systolic and diastolic dysfunction, neurohormonal dysregulation, and imbalance in inflammatory mediators which complicates treatment further. Cardiac resynchronization therapy (CRT) is an approach used for restoring ventricular synchrony and enhancing mechanical efficiency.

Diagnosed with Endoscopic Ultrasound and Treated with Endoscopic Retrograde Cholangio Pancreatography: A Case Report.

This article discusses infection, a zoonotic parasite that lives in the liver bile ducts. A 31-year-old female patient was diagnosed with symptoms such as nausea, increased liver enzymes, and right upper quadrant pain for about a year. The parasite was detected in the common bile duct by Endoscopic Ultrasound (EUS) and removed by Endoscopic Retrograde Cholangio Pancreatography (ERCP).

Comparison of classical methods for bone age determination with Capitohamate planimetry on wrist X-rays.

Background/aim: This study aims to compare the Greulich-Pyle (GP) and Tanner-Whitehouse 2 (TW2) methods, both used in left wrist radiography for bone age determination in the pediatric age group, with the Capitohamatum method (CH) due to the importance of determining bone age in the pediatric period.

Materials And Methods: Direct radiographs of 210 female and 291 male individuals between the ages of 0-15 without any pathology in the left wrist bones were obtained; 501 os capitatum and os hamatum on anterior-to-posterior direct graphic images were measured using the GP, TW2, and CH planimetry methods. The estimated age of each measurement was calculated by evaluating the relationship between chronological age and sex.

The relationship between clinical prognostic factors, microvascular density, and tumor-infiltrating lymphocytes with CD47 and SIRPα expression in diffuse large B cell lymphomas.

CD47 interacts with signal regulatory protein alpha (SIRPα) on macrophages to deliver an anti-phagocytic signal, enabling tumor cells to evade immune destruction. This study explores the relationship between CD47 and SIRPα expression and key clinical prognostic factors, microvascular density (MVD), and tumor-infiltrating lymphocytes (TIL) in Diffuse Large B Cell Lymphoma (DLBCL) cases. We analyzed tissue samples from 122 DLBCL cases using tissue microarray (TMA) blocks and immunohistochemical staining for CD47, SIRPα, CD31, and CD3.

Applying machine learning-based multiple imputation methods to nonparametric multiple comparisons in longitudinal clinical studies.

Dependent samples, in which repeated measurements are made on the same subjects, eliminate potential differences among the subjects. In k-dependent samples, missing data can occur for various reasons. The Skillings-Mack test is used instead of the Friedman test for k-dependent samples with missing observations that are non-normally distributed.

Development, reliability, and validity of the nurses' conscientious objection attitude scale (COAS-N).

Background: Conscientious objection poses ethical dilemmas frequently encountered by nurses, allowing them to prioritize personal beliefs in caregiving. However, it may also be viewed as a stance jeopardizing patients' healthcare access. There is no measurement tool to measure conscientious objection in nurses.

Immediate Effects of Whole Body Vibration on Proprioception and Upper Extremity Reaction Speed in Young Adult Students.

Background: There is limited information on the immediate effects of whole-body vibration (WBV) on the upper limb. This study aims to determine the immediate effects of WBV on reaction speed and proprioception in young adult students' upper extremities.

Methods: In total, 62 students participated in the study.

Predictive value of hematologic parameters and HALP score for testicular viability in adults with testicular torsion: A multicentric study.

Objectives: To evaluate the predictivity of haematologic parameters and HALP score on testicular viability in adults with testicular torsion.

Methods: We retrospectively analyzed the clinical data of 139 men ≥18 years of age who underwent testicular detorsion with fixation (n = 90) or orchiectomy (n = 49) due to testicular torsion in five different tertiary centers between May 2019 and August 2023. Demographic, pre-, peri- and postoperative data were analyzed.

DISTAL URETHRAL DUPLICATION IN A FEMALE CHILD: A UNIQUE CASE REPORT WITH DIVERTICULAR COMPONENT.

Study Objective: To report a rare case of urethral duplication in a 5-year-9-month-old girl and describe the surgical approach and outcomes.

Methods: A 5-year-9-month-old girl presented with post-void dribbling and clitoral swelling. Physical examination and imaging were performed.

DEHP impairs the oxidative stress response and disrupts trace element and mineral metabolism within the mitochondria of detoxification organs.

Di(2-ethylhexyl) phthalate (DEHP), a widely utilized plasticizer in various consumer products, is classified as an endocrine disruptor and has been implicated in numerous adverse health effects, including oxidative stress, inflammation, and metabolic disturbances. Despite the growing body of literature addressing the systemic effects of DEHP, the specific influence of DEHP-induced oxidative stress on mitochondrial function within detoxification organs, particularly the liver and kidneys, remains largely unexplored. This study evaluated the effects of DEHP exposure (0, 100, 200, and 400 mg/kg/day) on mitochondrial oxidative stress, trace elements, and mineral metabolism associated with signaling pathways in the liver and kidneys of rats.

Hepatitis A virus infection and seroprevalence, Istanbul, Turkey, 2020-2023.

Background: Hepatitis A infections continue to be a major global public health problem. The epidemiology and seroprevalence of hepatitis A virus (HAV) have important public health implications. This study aimed to retrospectively examine the hepatitis A cases and hepatitis A seroprevalence in our region in our hospital with the highest number of inpatient and outpatient cases in Istanbul.

Risk Factors For Progression From Biochemical Leak to Clinically Relevant Postoperative Pancreatic Fistula After Pancreaticoduodenectomy. The Key of the Lock: Prognostic Nutritional Index.

Background/aims: Postoperative pancreatic fistula (POPF), which is considered the most frightening complication after pancreatic oduodenectomy (PD), continues to be a serious problem even in experienced centers. In the present study, we aimed to determine the risk factors that increase the progression from biochemical leak (BL) to clinically relevant postoperative pancreatic fistula (CR-POPF) after PD.

Materials And Methods: We retrospectively analyzed the data of 152 patients who underwent PD.

Multidisciplinary Approach to Perihilar and Intrahepatic Cholangiocarcinoma: A Single-Center Experience.

Background/aims: Treatment of perihilar cholangiocarcinoma (PHCC) and intrahepatic cholangiocarcinoma (IHCC) is a challenging issue. We aimed to investigate the clinical characteristics of both tumors and the outcome of our treatment policy.

Material And Methods: We retrospectively analyzed data of 117 patients who were diagnosed with PHCC or IHCC between January 2007 and September 2023.

Neuroprotective Roles of Lauric Acid and Resveratrol: Shared Benefits in Neuroinflammation and Anxiety, Distinct Effects on Memory Enhancement.

Neuroinflammation can be triggered by a high-fat/high-fructose diet (HFFD), and CD36 may be an underlying mechanism. Lauric acid (LA), the major fatty acid in coconut oil, and resveratrol, the plant-based polyphenolic compound, may exert anti-inflammatory effects. Therefore, this study investigated the possible effects of LA and resveratrol on diet-induced neuroinflammation and CD36.

How much do we know about nanobacteria?

Background/purpose: Nanobacteria, known to date as self-replicating, nano-scale size organisms, smaller than bacteria. However, whether these are living organisms or agglomeration of biomolecules was one of the most controversial issues for many years. One of the reasons for debate is their lack of any genetic material.

Evaluation of White Matter Integrity by Using Diffusion Tensor Imaging in Patients with Presbycusis.

Rationale And Objectives: This study aims to evaluate white matter microstructure integrity in patients diagnosed with presbycusis (age-related hearing loss) using diffusion tensor imaging (DTI) and to investigate the relationship between DTI parameters and hearing loss severity.

Materials And Methods: Patients aged 50 and above with presbycusis (pure-tone average [PTA] ≥20dB) were categorized as mild (PTA 20-34dB), moderate (PTA 35-49dB), or severe (PTA ≥50dB). Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured in 16 white matter regions.

Spiritual Meaning Making and Trauma Recovery: Evaluation of a Psycho-social Intervention for Earthquake Survivors in Turkey.

This study sets out to develop a psycho-social model for assessing the effectiveness of spiritually oriented logotherapy for earthquake victims with PTSD following the 6 February 2023, Kahramanmaraş earthquake in Turkey. The findings of this study will undoubtedly contribute to the development of post-disaster spiritual support services. We developed and implemented a six-week "Psycho-Social Training Programme through Spiritually Oriented Meaning" in the cities of Malatya, Elazığ and Kahramanmaraş, which were significantly affected by the earthquake.