The effect of art therapy on cognitive status and psychological well-being in elderly people in institutional care.

Background: Cognitive decline seen in old age manifests itself as a decrease in reasoning ability that is not related to intelligence. This situation, together with many other problems, can affect the psychological well-being of the elderly. Especially the elderly living in institutional care constitute a special group that needs to be protected.

Detection of glycopeptide resistance and virulence genes in enterococci isolated from cheese and investigation of the clonal relationship of E. faecium species with rectal surveillance isolates.

Objective: This study aimed to investigate the presence of glycopeptide resistance and virulence genes in Enterococcus spp. isolated from cheese and the clonal relationship of E. faecium species with rectal surveillance isolates.

The expression of the lncRNAs USP30-AS1, ELFN1-AS1, GAS8-AS1, and SNHG11 in breast cancer samples from Iranian patients from 2014 to 2019: a cross-sectional study.

Objective: Breast cancer is a widely prevalent and life-threatening malignancy that affects women worldwide. The identification of novel molecular markers associated with tumor progression is highly important for enhancing early detection, tailoring treatment approaches, and monitoring therapeutic outcomes. In this study, we investigated the expression patterns of four long noncoding RNAs (lncRNAs): USP30 antisense RNA1 (USP30-AS1), ELFN1 antisense RNA1 (ELFN1-AS1), GAS8 antisense RNA1 (GAS8-AS1), and small nucleolar RNA host gene 11 (SNHG11).

Unraveling the Exosome-miR-133a Axis: Targeting TGF-β Signaling via WJ-MSC-Derived Exosomes for Anti-Fibrotic Therapy in Liver Fibrosis.

Background: One of the primary drivers of liver fibrosis is the excessive accumulation of ECM, primarily caused by the over-proliferation of HSCs. The activation of HSCs by TGF-β has a critical role in initiating fibrosis. Recent studies have suggested that miRNA-133a significantly regulates the fibrogenesis process, which its downregulation is associated with the fibrosis progression.

Isolation of new isoflavonoids derivatives from Griseb. and biological activity.

The genus L. has been used in the treatment of rheumatic, diabetic and ulcerous diseases. Herein, the antioxidant, anticholinesterase, and antidiabetic activities of Griseb.

Application of response surface methodology for bioenergy generation in a yeast-based microbial fuel cell.

Microbial fuel cells (MFCs) provide a solution to valorise wastewater for energy generation. Wastewater containing oxytetracycline (OTC), an antibiotic, was treated in a yeast-based H-type MFC to obtain bioenergy. The effect of bakery yeast amount, initial OTC concentration, and NaCl concentration in an anodic chamber was investigated and optimum operating conditions were statistically determined Box-Behnken design.

Sharing for Caring? A Patients' and Clinicians' View on Handling Personal Medical Data in the Context of Digitization: An Exploratory Study.

Background: The healthcare sector is currently undergoing a significant transformation, driven by an increased utilization of data. In this evolving landscape, surveys are of pivotal importance to the comprehension of patient needs and preferences. Moreover, the digital affinity of patients and physicians within the healthcare system is reforming the manner in which healthcare services are accessed and delivered.

Polysaccharides and Peptides With Wound Healing Activity From Bacteria and Fungi.

Bacteria and fungi are natural sources of metabolites exhibiting diverse bioactive properties such as wound healing, antioxidative, antibacterial, antifungal, anti-inflammatory, antidiabetic, and anticancer activities. Two important groups of bacteria or fungi-derived metabolites with wound-healing potential are polysaccharides and peptides. In addition to bacteria-derived cellulose and hyaluronic acid and fungi-derived chitin and chitosan, these organisms also produce different polysaccharides (e.

Epileptic Encephalopathy of Unknown Cause in Turkey Indicates a New Homozygous Gene Variant.

Introduction: As with many genetic diseases, the diagnostic role of next-generation sequencing is invaluable for early-onset epileptic encephalopathies. SNARE proteins in synaptic vesicles (synaptobrevin-2) and synaptic plasma membrane (syntaxin-1, SNAP-25) are involved in synaptic exocytosis and recycling.

Patient Presentation: Here, we report a patient that started in early childhood with seizures resistant to antiepileptic drugs, then developed epileptic encephalopathy.

The prognostic value of HALP score and sPESI in predicting in-hospital mortality in patients with pulmonary thromboembolism.

Background: Pulmonary thromboembolism (PTE), often arising from deep vein thrombosis, remains a high-mortality condition despite diagnostic advancements. Prognostic models like Pulmonary Embolism Severity Index (PESI) and sPESI identify low-risk groups effectively. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score, reflecting nutritional status and systemic inflammation, shows prognostic value in cancers and cardiovascular diseases.

Evaluation of GFAP, S100B, and UCHL-1 Levels in Children With Refractory Epilepsy.

Introduction: A number of biomarkers are used to evaluate the duration of the epileptic seizure and the interictal period following neuronal injury. Invasive diagnostic methods are increasingly being replaced by peripheral or minimally invasive biomarkers that give results faster and are more secure.

Purpose: We aimed to evaluate serum glial fibrillary acidic protein (GFAP), S100B, and ubiquitin C-terminal hydrolase (UCHL-1) levels in children with epilepsy.

Curcumin and saroglitazar attenuate diet-induced nonalcoholic steatohepatitis by activating the Nrf2 pathway and suppressing ERK1/2 signaling.

Objectives: Non-alcoholic fatty liver disease (NAFLD) is a chronic steatohepatitis disorder. If left untreated, it can progress to hepatocellular carcinoma. Several studies have shown that saroglitazar, a PPARα/γ dual agonist, and curcumin (the principal constituent of turmeric) may be effective in the treatment of NAFLD.

Neurocognitive effects and electrophysiological findings in ADHD and self-limiting centrotemporal spike wave epilepsy (SeLECTS) - A prospective tertiary care study.

Objective: The study aimed to determine the prevalence of attention deficit hyperactivity disorder (ADHD) in patients with self-limiting epilepsy with centrotemporal spike wave (SeLECTS), as well as the electroclinical features associated with this comorbid condition and the neurocognitive effects using psychometric tests. Additionally, we analysed the electrophysiological findings and neurocognitive status of patients with ADHD to estimate the prevalence of epilepsy and neurocognitive effects in the ADHD population and evaluate their clinical features.

Method: The study included patients diagnosed with SeLECTS and ADHD who were matched for age and gender.

The effect of erector spinae plane block on postoperative extubation time and laboratory parameters in open heart surgery: a retrospective study.

Background/aim: In open heart surgery, sternotomy causes inflammation in tissues, and inflammation causes postoperative pain. This study aims to examine the effects of bilateral erector spinae plane (ESP) blocks on postoperative extubation time and laboratory parameters in open heart surgery.

Materials And Methods: The study was managed using retrospective data from 85 patients who underwent open-heart surgery.

The impact of a "clinical adaptation psychoeducation program" grounded in the psychological flexibility model on perceived stress and coping behaviors among nursing students: A randomized controlled experimental study.

Background: The clinical adaptation psychoeducation program grounded psychological flexibility model (PFMCAP) is consisting of six areas, fills a large gap in the literature regarding the effect of nursing students on perceived stress and coping behaviors in the clinical process.

Objectives: To determine the effect of PFMCAP on perceived stress and coping behaviors of nursing students.

Design: This was a simple randomized controlled experimental pre-posttest design.

Efficacy and Advantages of Spinal Anesthesia in Lumbar Disk Surgery.

Background:  Quality of life (QoL) may be affected due to various reasons such as low back or leg pains with accompanying neurologic problems. Lumbar disk surgery is one of the most common performed surgeries to relieve those symptoms. Various anesthetic techniques can be used safely to perform lumbar disk surgeries.

Comparison of the anti-inflammatory and antilipidemic activity of diosmin and saroglitazar in a model of nonalcoholic fatty liver induced by a high-fat diet in Wistar rats.

Objectives: Non-alcoholic fatty liver disease (NAFLD) is the most common liver-related metabolic disorder in the world, with a global prevalence of 25%. Compounds with anti-inflammatory, lipid-lowering, and insulin-sensitizing properties can be used for the prevention or treatment of NAFLD. Therefore, this study was conducted to investigate the effect of saroglitazar (a dual PPARα/γ agonist) and diosmin (a flavonoid) on non-alcoholic fatty liver induced by a high-fat diet (HFD) in Wistar rats.

Providing a comprehensive approach to oil well blowout risk assessment.

Drilling is one of the most dangerous activities in the oil and gas process industries. Therefore, a holistic approach was presented to prevent and control risks and reduce the uncertainty of blowouts, kick scenarios, and control layers based on the Fuzzy Bayesian Network (FBN). Four independent protection layers (IPLs) were used to evaluate the blowout outcome, and the failure probabilities of IPL1 and IPL2 were calculated with Fault Tree Analysis (FTA).

Optic neuritis in Turkish children and adolescents: A multicenter retrospective study.

Background: Various etiologies may underlie optic neuritis, including autoantibody-mediated disorders described in the last decade. We re-examined demographic, clinical, laboratory features and prognostic factors in pediatric patients with autoimmune optic neuritis according to current knowledge.

Methods: Cases of pediatric ON from 27 centers in Türkiye diagnosed between 2009 and 2022 were included for retrospective evaluation.

"Silent screams": Family perceptions in the drawings of incest victim children.

Purpose: This study aimed to examine the family perceptions in the drawings of children exposed to incest.

Design And Methods: This qualitative research involved 25 child survivors of incest, all of whom were examined and subjected to forensic interviews at a facility in northern Türkiye specializing in cases of child sexual abuse. The data were collected using the "Child and Family Descriptive Information Form", the "Abuser Descriptive Information Form", the "Family Drawing Test", and the "Semi-structured Interview Form".